Explore top 2025 4 Star Hotels in Florida Keys

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Top Florida Keys 4 Star hotels

Hawks Cay Resort

Hawks Cay Resort

4 out of 5
61 Hawks Cay Blvd, Marathon, FL
Fully refundableReserve now, pay when you stay
$362 nightly
The price is $406 total per night from Sep 30 to Oct 1
$406 total
Sep 30 - Oct 1
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and a marina. Spend a day at the beach snorkeling, or relax with sun loungers and beach umbrellas. ...
8/10 Very Good! (1,007 reviews)
"Had an amazing and relaxed time with my family! Dolphin encounter was so much fun and educational. I do recommend having a microwave in rooms. Thank you for the amazing hospitality 🙏"

Reviewed on Sep 15, 2025

Opens in a new windowHawks Cay Resort
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

4 out of 5
97000 Overseas Hwy, Key Largo, FL
Fully refundableReserve now, pay when you stay
$320 nightly
The price is $360 total per night from Oct 6 to Oct 7
$360 total
Oct 6 - Oct 7
Total with taxes and fees
A private beach, 2 restaurants, and 2 outdoor pools are all featured at this resort. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. ...
8.6/10 Excellent! (1,029 reviews)
"Didn’t like the food options and the hotel needs some updates, specially the rooms. The rest was great."

Reviewed on Sep 23, 2025

Opens in a new windowBaker's Cay Resort Key Largo, Curio Collection by Hilton
Amara Cay Resort

Amara Cay Resort

4 out of 5
80001 Overseas Hwy, Islamorada, FL
Fully refundableReserve now, pay when you stay
$227 nightly
The price is $256 total per night from Oct 2 to Oct 3
$256 total
Oct 2 - Oct 3
Total with taxes and fees
A private beach, 2 restaurants, and an outdoor pool are all featured at this resort. If you want to take your pet along, this pet-friendly property offers everything ...
8.8/10 Excellent! (1,260 reviews)
"The resort had free kayaking and paddle boarding which was a great addition."

Reviewed on Sep 22, 2025

Opens in a new windowAmara Cay Resort
Islander Resort

Islander Resort

4 out of 5
82100 Overseas Highway, Islamorada, FL
Fully refundableReserve now, pay when you stay
$247 nightly
The price is $278 total per night from Oct 2 to Oct 3
$278 total
Oct 2 - Oct 3
Total with taxes and fees
A private beach, 3 restaurants, and 2 outdoor pools are all featured at this hotel. Enjoy beachfront dining and relax with beach cabanas and sun loungers. Families ...
9/10 Wonderful! (1,021 reviews)
"The staff is very friendly and helpful. The property is very nice."

Reviewed on Sep 28, 2025

Opens in a new windowIslander Resort
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

4.5 out of 5
97450 Overseas Highway, Key Largo, FL
Fully refundableReserve now, pay when you stay
$288 nightly
The price is $324 total per night from Oct 6 to Oct 7
$324 total
Oct 6 - Oct 7
Total with taxes and fees
This luxury resort features a full-service spa, a marina, and 3 restaurants. Enjoy beachfront dining and relax with beach cabanas and sun loungers. Enjoy the ...
8.8/10 Excellent! (1,002 reviews)
"By far one of the best hotels in the keys."

Reviewed on Sep 21, 2025

Opens in a new windowPlaya Largo Resort & Spa, Autograph Collection
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

4 out of 5
2600 Overseas Hwy, Marathon, FL
Fully refundableReserve now, pay when you stay
$281 nightly
The price is $317 total per night from Oct 19 to Oct 20
$317 total
Oct 19 - Oct 20
Total with taxes and fees
This smoke-free hotel features a private beach, 3 outdoor pools, and a restaurant. Business travelers can take advantage of the free WiFi in public areas. Enjoy ...
8.8/10 Excellent! (1,002 reviews)
"Me encantó en todos los sentidos. Volvería con toda seguridad."

Reviewed on Sep 25, 2025

Opens in a new windowTranquility Bay Beachfront Hotel and Resort
La Siesta Resort & Villas

La Siesta Resort & Villas

4 out of 5
80241 Overseas Highway, Islamorada, FL
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $269 total per night from Oct 7 to Oct 8
$269 total
Oct 7 - Oct 8
Total with taxes and fees
The private beach and marina are among the highlights at this resort. Enjoy the outdoor pool and perks like a free area shuttle. There's a poolside bar on site, ...
8.6/10 Excellent! (1,006 reviews)
"Great rooms"

Reviewed on Sep 20, 2025

Opens in a new windowLa Siesta Resort & Villas
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

4 out of 5
1996 Overseas Highway, Marathon, FL
Fully refundableReserve now, pay when you stay
$191 nightly
The price is $215 total per night from Oct 8 to Oct 9
$215 total
Oct 8 - Oct 9
Total with taxes and fees
A marina, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free resort. Traveling on business? Take advantage of the 3 conference rooms, along ...
8.8/10 Excellent! (1,278 reviews)
"I will recommended"

Reviewed on Sep 21, 2025

Opens in a new windowFaro Blanco Resort & Yacht Club Marathon, Curio by Hilton
Villas At Hawks Cay Resort

Villas At Hawks Cay Resort

4 out of 5
61 Hawks Cay Boulevard, Villas, Marathon, FL
This luxury resort features a private beach, a full-service spa, and a marina. Spend a day at the beach snorkeling, or relax with sun loungers and beach umbrellas. ...
8.4/10 Very Good! (136 reviews)
"It was slow season so a lot of things were closed in the area but overall is a great place"

Reviewed on Sep 24, 2025

Opens in a new windowVillas At Hawks Cay Resort
The Islands of Islamorada

The Islands of Islamorada

4 out of 5
82779 Old Hwy, Islamorada, FL
Fully refundableReserve now, pay when you stay
$599 nightly
The price is $674 total per night from Sep 30 to Oct 1
$674 total
Sep 30 - Oct 1
Total with taxes and fees
2 outdoor pools, a 24-hour gym, and a hot tub are all featured at this smoke-free villa. Spend a day at the beach kayaking, or relax with sun loungers and beach ...
9.6/10 Exceptional! (66 reviews)
"Beautiful property!"

Reviewed on Aug 4, 2025

Opens in a new windowThe Islands of Islamorada
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4 Star Hotels Florida Keys

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Florida Keys 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Florida Keys will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Florida Keys, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Florida Keys hotel reviews by fellow wanderers