Explore top 2026 4 Star Hotels in Florida Keys
Seize Your Someday with our amazing deals for the whole family!
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Check prices for these dates
Top Florida Keys 4 Star hotels
Reefhouse Resort & Marina
103800 Overseas Hwy Key Largo FL
Fully refundableReserve now, pay when you stay
$339 nightly
The price is $376 total per night from Apr 19 to Apr 20
$376 total
Apr 19 - Apr 20
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and a marina. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Family-friendly ...
9.4/10 Exceptional! (1,403 reviews)
We had a fantastic stay at the Reef House in Key Largo! They won us over right from the start—when we asked about a possible upgrade, they went above and beyond. We had originally booked a one-room with two beds and were pleasantly surprised to be upgraded to a spacious two-bedroom with a kitchen ...
Reviewed on Apr 7, 2026
Baker's Cay Resort Key Largo, Curio Collection by Hilton
97000 Overseas Hwy Key Largo FL
$376 nightly
The price is $423 total per night from Apr 21 to Apr 22
$423 total
Apr 21 - Apr 22
Total with taxes and fees
A private beach, 2 restaurants, and 2 outdoor pools are all featured at this resort. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. ...
8.6/10 Excellent! (1,025 reviews)
Small shops
Reviewed on Apr 5, 2026
Amara Cay Resort
80001 Overseas Hwy Islamorada FL
$291 nightly
The price is $328 total per night from Apr 20 to Apr 21
$328 total
Apr 20 - Apr 21
Total with taxes and fees
A private beach, 2 restaurants, and an outdoor pool are all featured at this resort. If you want to take your pet along, this pet-friendly property offers everything ...
8.8/10 Excellent! (1,267 reviews)
Great
Reviewed on Mar 30, 2026
Hawks Cay Resort
61 Hawks Cay Blvd Marathon FL
Fully refundableReserve now, pay when you stay
$352 nightly
The price is $395 total per night from Apr 12 to Apr 13
$395 total
Apr 12 - Apr 13
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and a marina. Spend a day at the beach snorkeling, or relax with sun loungers and beach umbrellas. ...
8/10 Very Good! (1,010 reviews)
Room was not ready until 6pm and was dirty
Reviewed on Apr 6, 2026
Islander Resort
82100 Overseas Highway Islamorada FL
$360 nightly
The price is $404 total per night from Apr 15 to Apr 16
$404 total
Apr 15 - Apr 16
Total with taxes and fees
A private beach, 3 restaurants, and 2 outdoor pools are all featured at this hotel. Enjoy beachfront dining and relax with beach cabanas and sun loungers. Families ...
9.4/10 Exceptional! (1,010 reviews)
My husband and I stayed here for our baby moon, and we honestly couldn’t recommend this place more! After doing a painful amount of research, it was difficult to decide between this resort and a few other ones we found, but I am so glad we went with The Islander. The grounds are beautiful, the staff ...
Reviewed on Apr 6, 2026
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
1996 Overseas Highway Marathon FL
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $286 total per night from May 3 to May 4
$286 total
May 3 - May 4
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 4 restaurants. Enjoy a day at the beach kayaking, or relax with sun loungers. Enjoy the 4 outdoor ...
8.8/10 Excellent! (1,179 reviews)
The room was clean, all staff was friendly, lots of shopping close by, the food at the restaurant was delicious. Would stay there again!
Reviewed on Apr 5, 2026
Playa Largo Resort & Spa, Autograph Collection
97450 Overseas Highway Key Largo FL
Fully refundableReserve now, pay when you stay
$408 nightly
The price is $459 total per night from May 4 to May 5
$459 total
May 4 - May 5
Total with taxes and fees
This luxury resort features a full-service spa, a marina, and 3 restaurants. Enjoy beachfront dining and relax with beach cabanas and sun loungers. Enjoy the ...
8.8/10 Excellent! (1,002 reviews)
Beautiful resort. Property is very well maintained. Wonderful staff. Can’t say enough good things about this place. I will definitely be coming back to this place.
Reviewed on Apr 7, 2026
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
84001 Overseas Hwy Islamorada FL
$356 nightly
The price is $400 total per night from Apr 22 to Apr 23
$400 total
Apr 22 - Apr 23
Total with taxes and fees
This Art Deco resort features a private beach, a marina, and 4 restaurants. Enjoy a day at the beach snorkeling, or relax with sun loungers. Families will appreciate ...
9/10 Wonderful! (181 reviews)
Pool staff great. Too windy to do beach activities our trip unfortunately. Hotel room was great. Beautiful views. Check in was an unfortunate process. We were hoping for an early check in, instead didn’t get checked in till after our guaranteed 4PM.
Reviewed on Apr 4, 2026
La Siesta Resort & Villas
80241 Overseas Highway Islamorada FL
$273 nightly
The price is $308 total per night from Apr 14 to Apr 15
$308 total
Apr 14 - Apr 15
Total with taxes and fees
The private beach and marina are among the highlights at this resort. Enjoy the outdoor pool and perks like a free area shuttle. There's a poolside bar on site, ...
8.6/10 Excellent! (1,000 reviews)
We had a wonderful stay in the BOTE House. Perfect for a small family and dogs with the fenced in yard. The staff was great and very accommodating. The access to the other resorts and amenities is also a huge plus. We will definitely be back!
Reviewed on Apr 6, 2026
Tranquility Bay Beachfront Hotel and Resort
2600 Overseas Hwy Marathon FL
Fully refundableReserve now, pay when you stay
$300 nightly
The price is $337 total per night from May 3 to May 4
$337 total
May 3 - May 4
Total with taxes and fees
This smoke-free hotel features a private beach, 3 outdoor pools, and a restaurant. Business travelers can take advantage of the free WiFi in public areas. Enjoy ...
8.8/10 Excellent! (1,000 reviews)
Prepare for expensive meals and drinks.
Reviewed on Apr 3, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
4 Star Hotels Florida Keys
Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?
Come on, you deserve it!
The best part about staying in Florida Keys 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.
Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.
The best four star hotels in Florida Keys will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!
If you’re looking for 4 star hotels in Florida Keys, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.
Recent Florida Keys hotel reviews by fellow wanderers
Waterside Suites & Marina
5 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Having a balcony one looking the canal was really nice. And, having two bathrooms in the suite was great."
A verified traveler stayed at Waterside Suites & Marina
More ways to wander Florida Keys
Flights to Florida Keys
The best fares to get you there
Florida Keys Hotels
Florida Keys Vacation Rentals
Great Deals on Alternative Accommodations
Florida Keys Car Rentals
Affordable cars to get you around town
Florida Keys Vacations
Save more by combining flights, hotels and cars
Things to do in Florida Keys