American Airlines Flight 4645 Deals & Information (2026/2027)

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American Airlines Flight 4645 Route Deals From $144

The cheapest prices found with in the last 7 days for return flights were $269 and $144 for one-way flights to O'Hare Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Sep 5 - Tue, Sep 8
SYR
Hancock Intl.
ORD
O'Hare Intl.
$269 Roundtrip, found 6 hours ago
$269
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Sep 5 from Hancock Intl. to O'Hare Intl., returning Tue, Sep 8, priced at $269 found 6 hours ago
Wed, Jun 10 - Sat, Jun 20
SYR
Hancock Intl.
ORD
O'Hare Intl.
$275 Roundtrip, found 1 day ago
$275
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jun 10 from Hancock Intl. to O'Hare Intl., returning Sat, Jun 20, priced at $275 found 1 day ago
Sat, Sep 5 - Tue, Sep 8
SYR
Hancock Intl.
ORD
O'Hare Intl.
$276 Roundtrip, found 6 hours ago
$276
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Sep 5 from Hancock Intl. to O'Hare Intl., returning Tue, Sep 8, priced at $276 found 6 hours ago
Sat, Sep 5 - Tue, Sep 8
SYR
Hancock Intl.
ORD
O'Hare Intl.
$279 Roundtrip, found 6 hours ago
$279
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Sep 5 from Hancock Intl. to O'Hare Intl., returning Tue, Sep 8, priced at $279 found 6 hours ago
Thu, Jul 2 - Tue, Jul 7
SYR
Hancock Intl.
ORD
O'Hare Intl.
$289 Roundtrip, found 5 days ago
$289
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Jul 2 from Hancock Intl. to O'Hare Intl., returning Tue, Jul 7, priced at $289 found 5 days ago
Wed, Jun 10 - Sat, Jun 20
SYR
Hancock Intl.
ORD
O'Hare Intl.
$296 Roundtrip, found 1 day ago
$296
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jun 10 from Hancock Intl. to O'Hare Intl., returning Sat, Jun 20, priced at $296 found 1 day ago
Sat, Sep 5 - Tue, Sep 8
SYR
Hancock Intl.
ORD
O'Hare Intl.
$296 Roundtrip, found 6 hours ago
$296
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Sep 5 from Hancock Intl. to O'Hare Intl., returning Tue, Sep 8, priced at $296 found 6 hours ago
Sat, Sep 5 - Tue, Sep 8
SYR
Hancock Intl.
ORD
O'Hare Intl.
$299 Roundtrip, found 6 hours ago
$299
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Sep 5 from Hancock Intl. to O'Hare Intl., returning Tue, Sep 8, priced at $299 found 6 hours ago
Thu, May 28 - Sun, May 31
SYR
Hancock Intl.
ORD
O'Hare Intl.
$301 Roundtrip, found 3 days ago
$301
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, May 28 from Hancock Intl. to O'Hare Intl., returning Sun, May 31, priced at $301 found 3 days ago
Thu, Jul 2 - Tue, Jul 7
SYR
Hancock Intl.
ORD
O'Hare Intl.
$306 Roundtrip, found 5 days ago
$306
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Jul 2 from Hancock Intl. to O'Hare Intl., returning Tue, Jul 7, priced at $306 found 5 days ago

Frequently asked questions

What route does flight number AA4645 take?
You'll be landing at Key West Intl. Airport from New York, NY Airport (LGA-LaGuardia) if you've booked a ticket on flight number AA4645. You'll be airborne for 3 hours and 20 minutes during this trip. It's also good to note that it conveniently travels non-stop.
What terminal does AA4645 fly out of?
Flight number AA4645 runs between LGA and EYW, and those booked on this flight normally board the aircraft from Terminal B.
What kind of plane is on flight number AA4645?
The route for AA4645 is usually LGA to Key West Intl. Airport, and the Embraer 175 is the type of plane you'll probably be taking off on.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4645 flight with Travelocity, please visit our Customer Service Portal.