American Airlines Flight 4645 Deals & Information (2026/2027)

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American Airlines Flight 4645 Route Deals From $61

The cheapest prices found with in the last 7 days for return flights were $232 and $61 for one-way flights to Lambert-St. Louis Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Nov 30 - Wed, Dec 2
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$232 Roundtrip, found 4 days ago
$232
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Nov 30 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Dec 2, priced at $232 found 4 days ago
Mon, Nov 30 - Tue, Dec 1
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$247 Roundtrip, found 4 days ago
$247
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Nov 30 from O'Hare Intl. to Lambert-St. Louis Intl., returning Tue, Dec 1, priced at $247 found 4 days ago
Mon, Nov 30 - Wed, Dec 2
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$261 Roundtrip, found 4 days ago
$261
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Nov 30 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Dec 2, priced at $261 found 4 days ago
Fri, Nov 13 - Sun, Nov 15
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$293 Roundtrip, found 1 day ago
$293
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Nov 13 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sun, Nov 15, priced at $293 found 1 day ago
Fri, Nov 13 - Sun, Nov 15
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$305 Roundtrip, found 1 day ago
$305
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Nov 13 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sun, Nov 15, priced at $305 found 1 day ago
Sat, Oct 3 - Sat, Oct 10
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$307 Roundtrip, found 18 hours ago
$307
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Sat, Oct 3 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sat, Oct 10, priced at $307 found 18 hours ago

Frequently asked questions

What route does flight number AA4645 take?
You'll be landing at Key West Intl. Airport from New York, NY Airport (LGA-LaGuardia) if you've booked a ticket on flight number AA4645. You'll be airborne for 3 hours and 20 minutes during this trip. It's also good to note that it conveniently travels non-stop.
What terminal does AA4645 fly out of?
Flight number AA4645 runs between LGA and EYW, and those booked on this flight normally board the aircraft from Terminal B.
What kind of plane is on flight number AA4645?
The route for AA4645 is usually LGA to Key West Intl. Airport, and the Embraer 175 is the type of plane you'll probably be taking off on.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4645 flight with Travelocity, please visit our Customer Service Portal.