American Airlines Flight 4645 Deals & Information (2026/2027)

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American Airlines Flight 4645 Route Deals From $145

The cheapest prices found with in the last 7 days for return flights were $269 and $145 for one-way flights to O'Hare Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Jul 29 - Mon, Aug 3
SYR
Hancock Intl.
ORD
O'Hare Intl.
$269 Roundtrip, found 3 days ago
$269
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 29 from Hancock Intl. to O'Hare Intl., returning Mon, Aug 3, priced at $269 found 3 days ago
Tue, Jun 16 - Tue, Jun 30
SYR
Hancock Intl.
ORD
O'Hare Intl.
$271 Roundtrip, found 5 days ago
$271
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jun 16 from Hancock Intl. to O'Hare Intl., returning Tue, Jun 30, priced at $271 found 5 days ago
Sat, Jun 13 - Mon, Jun 15
SYR
Hancock Intl.
ORD
O'Hare Intl.
$275 Roundtrip, found 10 hours ago
$275
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Sat, Jun 13 from Hancock Intl. to O'Hare Intl., returning Mon, Jun 15, priced at $275 found 10 hours ago
Thu, Jul 9 - Tue, Jul 14
SYR
Hancock Intl.
ORD
O'Hare Intl.
$276 Roundtrip, found 5 days ago
$276
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Jul 9 from Hancock Intl. to O'Hare Intl., returning Tue, Jul 14, priced at $276 found 5 days ago
Wed, Jul 29 - Mon, Aug 3
SYR
Hancock Intl.
ORD
O'Hare Intl.
$279 Roundtrip, found 3 days ago
$279
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 29 from Hancock Intl. to O'Hare Intl., returning Mon, Aug 3, priced at $279 found 3 days ago
Tue, Jun 16 - Tue, Jun 30
SYR
Hancock Intl.
ORD
O'Hare Intl.
$281 Roundtrip, found 5 days ago
$281
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jun 16 from Hancock Intl. to O'Hare Intl., returning Tue, Jun 30, priced at $281 found 5 days ago
Sat, Jun 13 - Mon, Jun 15
SYR
Hancock Intl.
ORD
O'Hare Intl.
$282 Roundtrip, found 10 hours ago
$282
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Sat, Jun 13 from Hancock Intl. to O'Hare Intl., returning Mon, Jun 15, priced at $282 found 10 hours ago
Sat, Jun 13 - Mon, Jun 15
SYR
Hancock Intl.
ORD
O'Hare Intl.
$286 Roundtrip, found 10 hours ago
$286
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Sat, Jun 13 from Hancock Intl. to O'Hare Intl., returning Mon, Jun 15, priced at $286 found 10 hours ago
Thu, May 7 - Mon, May 11
SYR
Hancock Intl.
ORD
O'Hare Intl.
$286 Roundtrip, found 5 days ago
$286
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, May 7 from Hancock Intl. to O'Hare Intl., returning Mon, May 11, priced at $286 found 5 days ago
Sat, Jun 13 - Mon, Jun 15
SYR
Hancock Intl.
ORD
O'Hare Intl.
$292 Roundtrip, found 10 hours ago
$292
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Sat, Jun 13 from Hancock Intl. to O'Hare Intl., returning Mon, Jun 15, priced at $292 found 10 hours ago

Frequently asked questions

What route does flight number AA4645 take?
You'll be landing at Key West Intl. Airport from New York, NY Airport (LGA-LaGuardia) if you've booked a ticket on flight number AA4645. You'll be airborne for 3 hours and 20 minutes during this trip. It's also good to note that it conveniently travels non-stop.
What terminal does AA4645 fly out of?
Flight number AA4645 runs between LGA and EYW, and those booked on this flight normally board the aircraft from Terminal B.
What kind of plane is on flight number AA4645?
The route for AA4645 is usually LGA to Key West Intl. Airport, and the Embraer 175 is the type of plane you'll probably be taking off on.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4645 flight with Travelocity, please visit our Customer Service Portal.