American Airlines Flight 4521 Deals & Information (2026/2027)

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American Airlines Flight 4521 Route Deals From $169

The cheapest prices found with in the last 7 days for return flights were $316 and $169 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Dec 7 - Fri, Dec 11
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$316 Roundtrip, found 1 day ago
$316
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Dec 7 from LaGuardia to Buffalo Niagara Intl., returning Fri, Dec 11, priced at $316 found 1 day ago
Mon, Dec 7 - Fri, Dec 11
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$326 Roundtrip, found 1 day ago
$326
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Dec 7 from LaGuardia to Buffalo Niagara Intl., returning Fri, Dec 11, priced at $326 found 1 day ago
Thu, Apr 29 - Sun, May 2
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$328 Roundtrip, found 15 hours ago
$328
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Thu, Apr 29 from LaGuardia to Buffalo Niagara Intl., returning Sun, May 2, priced at $328 found 15 hours ago
Fri, Nov 13 - Sun, Nov 15
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$334 Roundtrip, found 1 day ago
$334
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Nov 13 from LaGuardia to Buffalo Niagara Intl., returning Sun, Nov 15, priced at $334 found 1 day ago
Thu, Oct 29 - Fri, Oct 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$335 Roundtrip, found 6 days ago
$335
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Oct 29 from LaGuardia to Buffalo Niagara Intl., returning Fri, Oct 30, priced at $335 found 6 days ago
Thu, Apr 29 - Sun, May 2
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$338 Roundtrip, found 15 hours ago
$338
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Thu, Apr 29 from LaGuardia to Buffalo Niagara Intl., returning Sun, May 2, priced at $338 found 15 hours ago
Fri, Nov 6 - Mon, Nov 9
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$347 Roundtrip, found 23 hours ago
$347
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Fri, Nov 6 from LaGuardia to Buffalo Niagara Intl., returning Mon, Nov 9, priced at $347 found 23 hours ago
Thu, Apr 29 - Sun, May 2
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$349 Roundtrip, found 15 hours ago
$349
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Thu, Apr 29 from LaGuardia to Buffalo Niagara Intl., returning Sun, May 2, priced at $349 found 15 hours ago
Fri, Nov 6 - Mon, Nov 9
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$357 Roundtrip, found 23 hours ago
$357
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Fri, Nov 6 from LaGuardia to Buffalo Niagara Intl., returning Mon, Nov 9, priced at $357 found 23 hours ago
Wed, Nov 4 - Wed, Nov 11
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$360 Roundtrip, found 15 hours ago
$360
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Nov 4 from LaGuardia to Buffalo Niagara Intl., returning Wed, Nov 11, priced at $360 found 15 hours ago
Fri, Oct 30 - Sat, Oct 31
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$478 Roundtrip, found 4 hours ago
$478
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Oct 30 from LaGuardia to Buffalo Niagara Intl., returning Sat, Oct 31, priced at $478 found 4 hours ago
Fri, Oct 30 - Sat, Oct 31
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$488 Roundtrip, found 4 hours ago
$488
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Oct 30 from LaGuardia to Buffalo Niagara Intl., returning Sat, Oct 31, priced at $488 found 4 hours ago
Fri, Oct 30 - Sat, Oct 31
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$498 Roundtrip, found 4 hours ago
$498
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Oct 30 from LaGuardia to Buffalo Niagara Intl., returning Sat, Oct 31, priced at $498 found 4 hours ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.