American Airlines Flight 4521 Deals & Information (2026/2027)

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American Airlines Flight 4521 Route Deals From $130

The cheapest prices found with in the last 7 days for return flights were $222 and $130 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Sep 29 - Wed, Sep 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$222 Roundtrip, found 1 day ago
$222
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 29 from LaGuardia to Buffalo Niagara Intl., returning Wed, Sep 30, priced at $222 found 1 day ago
Tue, Sep 29 - Wed, Sep 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$232 Roundtrip, found 1 day ago
$232
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 29 from LaGuardia to Buffalo Niagara Intl., returning Wed, Sep 30, priced at $232 found 1 day ago
Tue, Oct 6 - Wed, Oct 7
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$232 Roundtrip, found 4 days ago
$232
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Oct 6 from LaGuardia to Buffalo Niagara Intl., returning Wed, Oct 7, priced at $232 found 4 days ago
Wed, Sep 23 - Sat, Sep 26
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$239 Roundtrip, found 3 days ago
$239
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Sep 23 from LaGuardia to Buffalo Niagara Intl., returning Sat, Sep 26, priced at $239 found 3 days ago
Tue, Sep 8 - Sat, Sep 12
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$251 Roundtrip, found 6 days ago
$251
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Sep 8 from LaGuardia to Buffalo Niagara Intl., returning Sat, Sep 12, priced at $251 found 6 days ago
Thu, Oct 22 - Fri, Oct 23
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$256 Roundtrip, found 1 day ago
$256
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 22 from LaGuardia to Buffalo Niagara Intl., returning Fri, Oct 23, priced at $256 found 1 day ago
Wed, Sep 23 - Sat, Sep 26
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$257 Roundtrip, found 3 days ago
$257
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Sep 23 from LaGuardia to Buffalo Niagara Intl., returning Sat, Sep 26, priced at $257 found 3 days ago
Fri, Nov 6 - Mon, Nov 9
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$258 Roundtrip, found 1 day ago
$258
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Nov 6 from LaGuardia to Buffalo Niagara Intl., returning Mon, Nov 9, priced at $258 found 1 day ago
Fri, Oct 30 - Sun, Nov 1
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$259 Roundtrip, found 1 day ago
$259
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Oct 30 from LaGuardia to Buffalo Niagara Intl., returning Sun, Nov 1, priced at $259 found 1 day ago
Tue, Sep 8 - Sat, Sep 12
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$261 Roundtrip, found 6 days ago
$261
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Sep 8 from LaGuardia to Buffalo Niagara Intl., returning Sat, Sep 12, priced at $261 found 6 days ago
Wed, Sep 23 - Sat, Sep 26
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$264 Roundtrip, found 3 days ago
$264
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Sep 23 from LaGuardia to Buffalo Niagara Intl., returning Sat, Sep 26, priced at $264 found 3 days ago
Tue, Sep 29 - Wed, Sep 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$267 Roundtrip, found 1 day ago
$267
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 29 from LaGuardia to Buffalo Niagara Intl., returning Wed, Sep 30, priced at $267 found 1 day ago
Thu, Nov 5 - Fri, Nov 6
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$268 Roundtrip, found 1 day ago
$268
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Nov 5 from LaGuardia to Buffalo Niagara Intl., returning Fri, Nov 6, priced at $268 found 1 day ago
Tue, Sep 29 - Wed, Sep 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$271 Roundtrip, found 1 day ago
$271
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 29 from LaGuardia to Buffalo Niagara Intl., returning Wed, Sep 30, priced at $271 found 1 day ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.