American Airlines Flight 4521 Deals & Information (2025/2026)

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American Airlines Flight 4521 Route Deals From $49

The cheapest prices found with in the last 7 days for return flights were $97 and $49 for one-way flights to O'Hare Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Nov 18 - Tue, Dec 2
PIT
Pittsburgh Intl.
ORD
O'Hare Intl.
$97 Roundtrip, found 14 hours ago
$97
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Tue, Nov 18 from Pittsburgh Intl. to O'Hare Intl., returning Tue, Dec 2, priced at $97 found 14 hours ago
Sat, Nov 15 - Tue, Nov 18
PIT
Pittsburgh Intl.
ORD
O'Hare Intl.
$99 Roundtrip, found 7 hours ago
$99
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sat, Nov 15 from Pittsburgh Intl. to O'Hare Intl., returning Tue, Nov 18, priced at $99 found 7 hours ago
Thu, Oct 30 - Fri, Oct 31
PIT
Pittsburgh Intl.
ORD
O'Hare Intl.
$158 Roundtrip, found 14 hours ago
$158
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Thu, Oct 30 from Pittsburgh Intl. to O'Hare Intl., returning Fri, Oct 31, priced at $158 found 14 hours ago
Fri, Oct 17 - Sat, Oct 18
PIT
Pittsburgh Intl.
ORD
O'Hare Intl.
$161 Roundtrip, found 2 hours ago
$161
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Fri, Oct 17 from Pittsburgh Intl. to O'Hare Intl., returning Sat, Oct 18, priced at $161 found 2 hours ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.