American Airlines Flight 4521 Deals & Information (2026/2027)

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American Airlines Flight 4521 Route Deals From $119

The cheapest prices found with in the last 7 days for return flights were $209 and $119 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Sep 23 - Wed, Sep 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$209 Roundtrip, found 1 day ago
$209
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 23 from LaGuardia to Buffalo Niagara Intl., returning Wed, Sep 30, priced at $209 found 1 day ago
Thu, Oct 15 - Wed, Oct 21
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$212 Roundtrip, found 18 hours ago
$212
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Thu, Oct 15 from LaGuardia to Buffalo Niagara Intl., returning Wed, Oct 21, priced at $212 found 18 hours ago
Fri, Sep 25 - Sat, Sep 26
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$213 Roundtrip, found 1 day ago
$213
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Sep 25 from LaGuardia to Buffalo Niagara Intl., returning Sat, Sep 26, priced at $213 found 1 day ago
Fri, Oct 2 - Mon, Oct 5
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$231 Roundtrip, found 1 day ago
$231
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Oct 2 from LaGuardia to Buffalo Niagara Intl., returning Mon, Oct 5, priced at $231 found 1 day ago
Fri, Nov 6 - Mon, Nov 9
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$238 Roundtrip, found 15 hours ago
$238
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Fri, Nov 6 from LaGuardia to Buffalo Niagara Intl., returning Mon, Nov 9, priced at $238 found 15 hours ago
Fri, Jun 25 - Sun, Jun 27
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$239 Roundtrip, found 4 hours ago
$239
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Jun 25 from LaGuardia to Buffalo Niagara Intl., returning Sun, Jun 27, priced at $239 found 4 hours ago
Wed, Sep 23 - Wed, Sep 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$244 Roundtrip, found 1 day ago
$244
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 23 from LaGuardia to Buffalo Niagara Intl., returning Wed, Sep 30, priced at $244 found 1 day ago
Fri, Jun 25 - Sun, Jun 27
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$249 Roundtrip, found 4 hours ago
$249
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Jun 25 from LaGuardia to Buffalo Niagara Intl., returning Sun, Jun 27, priced at $249 found 4 hours ago
Thu, Aug 27 - Tue, Sep 1
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$252 Roundtrip, found 5 hours ago
$252
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Thu, Aug 27 from LaGuardia to Buffalo Niagara Intl., returning Tue, Sep 1, priced at $252 found 5 hours ago
Fri, Jun 25 - Sun, Jun 27
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$259 Roundtrip, found 4 hours ago
$259
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Jun 25 from LaGuardia to Buffalo Niagara Intl., returning Sun, Jun 27, priced at $259 found 4 hours ago
Thu, Aug 27 - Tue, Sep 1
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$262 Roundtrip, found 5 hours ago
$262
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Thu, Aug 27 from LaGuardia to Buffalo Niagara Intl., returning Tue, Sep 1, priced at $262 found 5 hours ago
Fri, Oct 2 - Sun, Oct 4
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$263 Roundtrip, found 6 hours ago
$263
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Oct 2 from LaGuardia to Buffalo Niagara Intl., returning Sun, Oct 4, priced at $263 found 6 hours ago
Fri, Oct 2 - Sun, Oct 4
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$267 Roundtrip, found 6 hours ago
$267
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Oct 2 from LaGuardia to Buffalo Niagara Intl., returning Sun, Oct 4, priced at $267 found 6 hours ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.