American Airlines Flight UA4521 Deals & Information (2025/2026)

Wander Wisely with exceptional service, 24/7 supportOpens in a new window

Feel at ease with free flight cancellations within 24 hours of booking

Change your flight without a fee on select flights

American Airlines Flight 4521 Route Deals From $49

The cheapest prices found with in the last 7 days for return flights were $97 and $49 for one-way flights to O'Hare Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Oct 9 - Mon, Oct 13
PIT
Pittsburgh Intl.
ORD
O'Hare Intl.
$97 Roundtrip, found 1 day ago
$97
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 9 from Pittsburgh Intl. to O'Hare Intl., returning Mon, Oct 13, priced at $97 found 1 day ago
Wed, Oct 22 - Fri, Oct 24
PIT
Pittsburgh Intl.
ORD
O'Hare Intl.
$133 Roundtrip, found 1 day ago
$133
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 22 from Pittsburgh Intl. to O'Hare Intl., returning Fri, Oct 24, priced at $133 found 1 day ago
Wed, Oct 22 - Thu, Oct 23
PIT
Pittsburgh Intl.
ORD
O'Hare Intl.
$152 Roundtrip, found 2 days ago
$152
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Oct 22 from Pittsburgh Intl. to O'Hare Intl., returning Thu, Oct 23, priced at $152 found 2 days ago
Thu, Oct 9 - Mon, Oct 13
PIT
Pittsburgh Intl.
ORD
O'Hare Intl.
$154 Roundtrip, found 1 day ago
$154
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 9 from Pittsburgh Intl. to O'Hare Intl., returning Mon, Oct 13, priced at $154 found 1 day ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.