American Airlines Flight 4521 Deals & Information (2026/2027)

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American Airlines Flight 4521 Route Deals From $160

The cheapest prices found with in the last 7 days for return flights were $259 and $160 for one-way flights to Lambert-St. Louis Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, May 11 - Mon, May 18
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$259 Roundtrip, just found
$259
Roundtrip
just found
Select American Airlines flight, departing Mon, May 11 from LaGuardia to Lambert-St. Louis Intl., returning Mon, May 18, priced at $259 just found
Mon, May 11 - Mon, May 18
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$269 Roundtrip, just found
$269
Roundtrip
just found
Select American Airlines flight, departing Mon, May 11 from LaGuardia to Lambert-St. Louis Intl., returning Mon, May 18, priced at $269 just found
Mon, May 11 - Mon, May 18
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$276 Roundtrip, just found
$276
Roundtrip
just found
Select American Airlines flight, departing Mon, May 11 from LaGuardia to Lambert-St. Louis Intl., returning Mon, May 18, priced at $276 just found
Mon, May 11 - Mon, May 18
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$346 Roundtrip, just found
$346
Roundtrip
just found
Select American Airlines flight, departing Mon, May 11 from LaGuardia to Lambert-St. Louis Intl., returning Mon, May 18, priced at $346 just found

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.