American Airlines Flight 4521 Deals & Information (2026/2027)

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American Airlines Flight 4521 Route Deals From $144

The cheapest prices found with in the last 7 days for return flights were $287 and $144 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Nov 6 - Sat, Nov 7
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$287 Roundtrip, found 4 days ago
$287
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Nov 6 from LaGuardia to Buffalo Niagara Intl., returning Sat, Nov 7, priced at $287 found 4 days ago
Fri, Nov 6 - Sat, Nov 7
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$297 Roundtrip, found 4 days ago
$297
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Nov 6 from LaGuardia to Buffalo Niagara Intl., returning Sat, Nov 7, priced at $297 found 4 days ago
Wed, Nov 25 - Tue, Dec 1
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$313 Roundtrip, found 6 days ago
$313
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Nov 25 from LaGuardia to Buffalo Niagara Intl., returning Tue, Dec 1, priced at $313 found 6 days ago
Sat, Nov 7 - Sun, Nov 8
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$319 Roundtrip, found 4 days ago
$319
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Nov 7 from LaGuardia to Buffalo Niagara Intl., returning Sun, Nov 8, priced at $319 found 4 days ago
Fri, Nov 6 - Sat, Nov 7
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$322 Roundtrip, found 4 days ago
$322
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Nov 6 from LaGuardia to Buffalo Niagara Intl., returning Sat, Nov 7, priced at $322 found 4 days ago
Sun, Nov 15 - Thu, Nov 19
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$324 Roundtrip, found 5 days ago
$324
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sun, Nov 15 from LaGuardia to Buffalo Niagara Intl., returning Thu, Nov 19, priced at $324 found 5 days ago
Sun, Nov 15 - Thu, Nov 19
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$325 Roundtrip, found 5 days ago
$325
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sun, Nov 15 from LaGuardia to Buffalo Niagara Intl., returning Thu, Nov 19, priced at $325 found 5 days ago
Tue, Dec 22 - Wed, Dec 30
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$327 Roundtrip, found 6 days ago
$327
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 22 from LaGuardia to Buffalo Niagara Intl., returning Wed, Dec 30, priced at $327 found 6 days ago
Sat, Nov 7 - Sun, Nov 8
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$329 Roundtrip, found 4 days ago
$329
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Nov 7 from LaGuardia to Buffalo Niagara Intl., returning Sun, Nov 8, priced at $329 found 4 days ago
Thu, Nov 19 - Sat, Nov 28
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$333 Roundtrip, found 4 days ago
$333
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Nov 19 from LaGuardia to Buffalo Niagara Intl., returning Sat, Nov 28, priced at $333 found 4 days ago
Sun, Nov 15 - Thu, Nov 19
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$334 Roundtrip, found 5 days ago
$334
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sun, Nov 15 from LaGuardia to Buffalo Niagara Intl., returning Thu, Nov 19, priced at $334 found 5 days ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.