American Airlines Flight DL4521 Deals & Information (2025/2026)

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American Airlines Flight 4521 Route Deals From $70

The cheapest prices found with in the last 7 days for return flights were $137 and $70 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Sep 9 - Wed, Sep 17
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$137 Roundtrip, found 6 days ago
$137
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Sep 9 from LaGuardia to Buffalo Niagara Intl., returning Wed, Sep 17, priced at $137 found 6 days ago
Wed, Oct 22 - Sun, Oct 26
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$147 Roundtrip, found 13 hours ago
$147
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Oct 22 from LaGuardia to Buffalo Niagara Intl., returning Sun, Oct 26, priced at $147 found 13 hours ago
Fri, Aug 1 - Mon, Aug 4
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$160 Roundtrip, found 17 hours ago
$160
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Fri, Aug 1 from LaGuardia to Buffalo Niagara Intl., returning Mon, Aug 4, priced at $160 found 17 hours ago
Fri, Nov 14 - Sat, Nov 15
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$172 Roundtrip, found 1 day ago
$172
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Nov 14 from LaGuardia to Buffalo Niagara Intl., returning Sat, Nov 15, priced at $172 found 1 day ago
Mon, Jul 28 - Fri, Aug 1
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$175 Roundtrip, found 3 days ago
$175
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Jul 28 from LaGuardia to Buffalo Niagara Intl., returning Fri, Aug 1, priced at $175 found 3 days ago
Thu, Sep 4 - Fri, Sep 5
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$178 Roundtrip, found 4 days ago
$178
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Sep 4 from LaGuardia to Buffalo Niagara Intl., returning Fri, Sep 5, priced at $178 found 4 days ago
Wed, Oct 22 - Sun, Oct 26
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$180 Roundtrip, found 13 hours ago
$180
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Oct 22 from LaGuardia to Buffalo Niagara Intl., returning Sun, Oct 26, priced at $180 found 13 hours ago
Mon, Aug 11 - Wed, Aug 13
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$192 Roundtrip, found 2 days ago
$192
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Aug 11 from LaGuardia to Buffalo Niagara Intl., returning Wed, Aug 13, priced at $192 found 2 days ago
Wed, Aug 20 - Thu, Aug 21
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$195 Roundtrip, found 1 day ago
$195
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Aug 20 from LaGuardia to Buffalo Niagara Intl., returning Thu, Aug 21, priced at $195 found 1 day ago
Tue, Sep 9 - Wed, Sep 17
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$197 Roundtrip, found 6 days ago
$197
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Sep 9 from LaGuardia to Buffalo Niagara Intl., returning Wed, Sep 17, priced at $197 found 6 days ago
Wed, Oct 22 - Sun, Oct 26
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$203 Roundtrip, found 13 hours ago
$203
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Oct 22 from LaGuardia to Buffalo Niagara Intl., returning Sun, Oct 26, priced at $203 found 13 hours ago
Wed, Aug 27 - Sun, Aug 31
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$207 Roundtrip, found 4 hours ago
$207
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Aug 27 from LaGuardia to Buffalo Niagara Intl., returning Sun, Aug 31, priced at $207 found 4 hours ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.