American Airlines Flight AA4521 Deals & Information (2025/2026)

Wander Wisely with exceptional service, 24/7 supportOpens in a new window

Feel at ease with free flight cancellations within 24 hours of booking

Change your flight without a fee on select flights

American Airlines Flight 4521 Route Deals From $79

The cheapest prices found with in the last 7 days for return flights were $137 and $79 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Sep 17 - Tue, Sep 23
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$137 Roundtrip, found 8 hours ago
$137
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Sep 17 from LaGuardia to Buffalo Niagara Intl., returning Tue, Sep 23, priced at $137 found 8 hours ago
Sat, Oct 18 - Mon, Oct 20
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$147 Roundtrip, found 6 hours ago
$147
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Oct 18 from LaGuardia to Buffalo Niagara Intl., returning Mon, Oct 20, priced at $147 found 6 hours ago
Wed, Jul 30 - Mon, Aug 4
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$159 Roundtrip, found 4 days ago
$159
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Jul 30 from LaGuardia to Buffalo Niagara Intl., returning Mon, Aug 4, priced at $159 found 4 days ago
Sat, Oct 18 - Mon, Oct 20
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$165 Roundtrip, found 6 hours ago
$165
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Oct 18 from LaGuardia to Buffalo Niagara Intl., returning Mon, Oct 20, priced at $165 found 6 hours ago
Thu, Sep 4 - Fri, Sep 5
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$167 Roundtrip, found 5 days ago
$167
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Sep 4 from LaGuardia to Buffalo Niagara Intl., returning Fri, Sep 5, priced at $167 found 5 days ago
Thu, Sep 25 - Sun, Sep 28
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$170 Roundtrip, found 7 hours ago
$170
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Thu, Sep 25 from LaGuardia to Buffalo Niagara Intl., returning Sun, Sep 28, priced at $170 found 7 hours ago
Thu, Oct 16 - Sat, Oct 18
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$172 Roundtrip, found 5 days ago
$172
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Oct 16 from LaGuardia to Buffalo Niagara Intl., returning Sat, Oct 18, priced at $172 found 5 days ago
Wed, Sep 17 - Sat, Sep 20
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$174 Roundtrip, found 15 hours ago
$174
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Sep 17 from LaGuardia to Buffalo Niagara Intl., returning Sat, Sep 20, priced at $174 found 15 hours ago
Sat, Oct 18 - Mon, Oct 20
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$177 Roundtrip, found 6 hours ago
$177
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Oct 18 from LaGuardia to Buffalo Niagara Intl., returning Mon, Oct 20, priced at $177 found 6 hours ago
Wed, Sep 17 - Mon, Sep 22
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$179 Roundtrip, found 8 hours ago
$179
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Sep 17 from LaGuardia to Buffalo Niagara Intl., returning Mon, Sep 22, priced at $179 found 8 hours ago

Frequently asked questions

What route does flight number AA4521 take?
AA4521 is used on multiple routes, but the most common is between CLT and Memphis Intl. Airport (MEM). If your flight is direct, you'll disembark the plane in 1 hour and 49 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
What kind of plane is on flight number AA4521?
If you've booked a ticket on flight AA4521 from Charlotte-Douglas Intl. Airport (CLT) to Memphis, TN Airport (MEM-Memphis Intl.), there's a strong chance you'll be traveling aboard the Embraer 175. Flight AA4521 serves several routes, but this is the most common one.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4521 flight with Travelocity, please visit our Customer Service Portal.