American Airlines Flight AA4121 Deals & Information (2025/2026)

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American Airlines Flight 4121 Route Deals From $181

The cheapest prices found with in the last 7 days for return flights were $332 and $181 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Aug 20 - Mon, Aug 25
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$332 Roundtrip, found 4 days ago
$332
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Aug 20 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Aug 25, priced at $332 found 4 days ago
Wed, Aug 20 - Mon, Aug 25
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$336 Roundtrip, found 4 days ago
$336
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Aug 20 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Aug 25, priced at $336 found 4 days ago
Thu, Sep 18 - Mon, Sep 22
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$340 Roundtrip, found 2 days ago
$340
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Sep 18 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Sep 22, priced at $340 found 2 days ago
Thu, Sep 18 - Mon, Sep 22
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$346 Roundtrip, found 2 days ago
$346
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Sep 18 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Sep 22, priced at $346 found 2 days ago
Wed, Aug 20 - Mon, Aug 25
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$355 Roundtrip, found 4 days ago
$355
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Aug 20 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Aug 25, priced at $355 found 4 days ago
Wed, Aug 20 - Mon, Aug 25
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$357 Roundtrip, found 4 days ago
$357
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Aug 20 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Aug 25, priced at $357 found 4 days ago
Wed, Aug 27 - Sat, Aug 30
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$359 Roundtrip, found 1 day ago
$359
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Aug 27 from Clinton National Airport to Charlotte-Douglas Intl., returning Sat, Aug 30, priced at $359 found 1 day ago
Thu, Sep 18 - Mon, Sep 22
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$362 Roundtrip, found 2 days ago
$362
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Sep 18 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Sep 22, priced at $362 found 2 days ago
Wed, Aug 20 - Mon, Aug 25
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$362 Roundtrip, found 4 days ago
$362
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Aug 20 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Aug 25, priced at $362 found 4 days ago
Wed, Aug 20 - Mon, Aug 25
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$363 Roundtrip, found 4 days ago
$363
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Aug 20 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Aug 25, priced at $363 found 4 days ago
Tue, Aug 5 - Sat, Aug 9
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$366 Roundtrip, found 6 days ago
$366
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Aug 5 from Clinton National Airport to Charlotte-Douglas Intl., returning Sat, Aug 9, priced at $366 found 6 days ago
Sat, Jul 19 - Sat, Jul 26
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$368 Roundtrip, found 6 days ago
$368
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Jul 19 from Clinton National Airport to Charlotte-Douglas Intl., returning Sat, Jul 26, priced at $368 found 6 days ago
Wed, Aug 27 - Sat, Aug 30
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$369 Roundtrip, found 1 day ago
$369
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Aug 27 from Clinton National Airport to Charlotte-Douglas Intl., returning Sat, Aug 30, priced at $369 found 1 day ago
Thu, Dec 25 - Tue, Dec 30
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$379 Roundtrip, found 19 hours ago
$379
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Thu, Dec 25 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Dec 30, priced at $379 found 19 hours ago
Thu, Dec 25 - Tue, Dec 30
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$389 Roundtrip, found 19 hours ago
$389
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Thu, Dec 25 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Dec 30, priced at $389 found 19 hours ago
Thu, Dec 25 - Tue, Dec 30
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$399 Roundtrip, found 19 hours ago
$399
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Thu, Dec 25 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Dec 30, priced at $399 found 19 hours ago

Frequently asked questions

What route does flight number AA4121 take?
AA4121 takes approximately 1 hour and 35 minutes to fly non-stop from O’Hare Airport to Buffalo, NY Airport (BUF-Buffalo Niagara Intl.). We all know there’s magic in the destination, but half the fun is in the journey!
What terminal does AA4121 fly out of?
AA4121 runs between O’Hare Intl. Airport (ORD) and Buffalo Niagara Intl. Airport (BUF), and passengers with a seat on this flight generally jet off from Terminal 3.
What kind of plane is on flight number AA4121?
The Embraer RJ145 is the type of plane most often used for flight AA4121. More often than not, this flight sets off from ORD and touches down at Buffalo, NY Airport (BUF-Buffalo Niagara Intl.).
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4121 flight with Travelocity, please visit our Customer Service Portal.