American Airlines Flight AA4121 Deals & Information (2025/2026)

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American Airlines Flight 4121 Route Deals From $206

The cheapest prices found with in the last 7 days for return flights were $366 and $206 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Aug 31 - Wed, Sep 10
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$366 Roundtrip, found 4 days ago
$366
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, Aug 31 from Clinton National Airport to Charlotte-Douglas Intl., returning Wed, Sep 10, priced at $366 found 4 days ago
Thu, Dec 25 - Tue, Dec 30
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$381 Roundtrip, found 8 hours ago
$381
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, Dec 25 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Dec 30, priced at $381 found 8 hours ago
Sat, Sep 20 - Sun, Sep 21
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$386 Roundtrip, found 12 hours ago
$386
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Sat, Sep 20 from Clinton National Airport to Charlotte-Douglas Intl., returning Sun, Sep 21, priced at $386 found 12 hours ago
Thu, Dec 25 - Tue, Dec 30
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$391 Roundtrip, found 8 hours ago
$391
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, Dec 25 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Dec 30, priced at $391 found 8 hours ago
Sat, Sep 20 - Sun, Sep 21
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$396 Roundtrip, found 12 hours ago
$396
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Sat, Sep 20 from Clinton National Airport to Charlotte-Douglas Intl., returning Sun, Sep 21, priced at $396 found 12 hours ago
Sat, Sep 20 - Sun, Sep 21
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$398 Roundtrip, found 12 hours ago
$398
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Sat, Sep 20 from Clinton National Airport to Charlotte-Douglas Intl., returning Sun, Sep 21, priced at $398 found 12 hours ago
Thu, Dec 25 - Tue, Dec 30
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$403 Roundtrip, found 8 hours ago
$403
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, Dec 25 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Dec 30, priced at $403 found 8 hours ago
Sat, Sep 20 - Sun, Sep 21
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$425 Roundtrip, found 12 hours ago
$425
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Sat, Sep 20 from Clinton National Airport to Charlotte-Douglas Intl., returning Sun, Sep 21, priced at $425 found 12 hours ago
Thu, Dec 25 - Tue, Dec 30
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$428 Roundtrip, found 8 hours ago
$428
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, Dec 25 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Dec 30, priced at $428 found 8 hours ago

Frequently asked questions

What route does flight number AA4121 take?
AA4121 takes approximately 1 hour and 35 minutes to fly non-stop from O'Hare Airport to Buffalo, NY Airport (BUF-Buffalo Niagara Intl.). We all know there's magic in the destination, but half the fun is in the journey!
What terminal does AA4121 fly out of?
AA4121 runs between O'Hare Intl. Airport (ORD) and Buffalo Niagara Intl. Airport (BUF), and passengers with a seat on this flight generally jet off from Terminal 3.
What kind of plane is on flight number AA4121?
The Embraer RJ145 is the type of plane most often used for flight AA4121. More often than not, this flight sets off from ORD and touches down at Buffalo, NY Airport (BUF-Buffalo Niagara Intl.).
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4121 flight with Travelocity, please visit our Customer Service Portal.