American Airlines Flight 4121 Deals & Information (2025/2026)

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American Airlines Flight 4121 Route Deals From $206

The cheapest prices found with in the last 7 days for return flights were $366 and $206 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Aug 31 - Wed, Sep 10
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$366 Roundtrip, found 3 days ago
$366
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sun, Aug 31 from Clinton National Airport to Charlotte-Douglas Intl., returning Wed, Sep 10, priced at $366 found 3 days ago
Sat, Aug 9 - Tue, Aug 12
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$440 Roundtrip, found 22 hours ago
$440
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Aug 9 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Aug 12, priced at $440 found 22 hours ago
Fri, Dec 26 - Mon, Dec 29
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$442 Roundtrip, found 20 hours ago
$442
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Fri, Dec 26 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Dec 29, priced at $442 found 20 hours ago
Sat, Aug 9 - Tue, Aug 12
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$450 Roundtrip, found 22 hours ago
$450
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Aug 9 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Aug 12, priced at $450 found 22 hours ago
Fri, Dec 26 - Mon, Dec 29
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$451 Roundtrip, found 20 hours ago
$451
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Fri, Dec 26 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Dec 29, priced at $451 found 20 hours ago
Sat, Aug 9 - Tue, Aug 12
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$468 Roundtrip, found 22 hours ago
$468
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Aug 9 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Aug 12, priced at $468 found 22 hours ago
Sat, Aug 9 - Tue, Aug 12
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$478 Roundtrip, found 22 hours ago
$478
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Aug 9 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Aug 12, priced at $478 found 22 hours ago
Fri, Dec 26 - Mon, Dec 29
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$481 Roundtrip, found 20 hours ago
$481
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Fri, Dec 26 from Clinton National Airport to Charlotte-Douglas Intl., returning Mon, Dec 29, priced at $481 found 20 hours ago
Sat, Aug 9 - Tue, Aug 12
LIT
Clinton National Airport
CLT
Charlotte-Douglas Intl.
$488 Roundtrip, found 22 hours ago
$488
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Aug 9 from Clinton National Airport to Charlotte-Douglas Intl., returning Tue, Aug 12, priced at $488 found 22 hours ago

Frequently asked questions

What route does flight number AA4121 take?
AA4121 takes approximately 1 hour and 35 minutes to fly non-stop from O'Hare Airport to Buffalo, NY Airport (BUF-Buffalo Niagara Intl.). We all know there's magic in the destination, but half the fun is in the journey!
What terminal does AA4121 fly out of?
AA4121 runs between O'Hare Intl. Airport (ORD) and Buffalo Niagara Intl. Airport (BUF), and passengers with a seat on this flight generally jet off from Terminal 3.
What kind of plane is on flight number AA4121?
The Embraer RJ145 is the type of plane most often used for flight AA4121. More often than not, this flight sets off from ORD and touches down at Buffalo, NY Airport (BUF-Buffalo Niagara Intl.).
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4121 flight with Travelocity, please visit our Customer Service Portal.