Book Hotels in Santee, NE

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Top Santee hotels

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Crofton NE
$817 nightly
The price is $903 total per night from Mar 8 to Mar 9
$903 total
Mar 8 - Mar 9
Total with taxes and fees
This vacation home includes a garden and laundry facilities.
Super clean and everything was ready for us plenty of room for 10 of us to enjoy together

Reviewed on Jan 6, 2026

Opens in a new windowModern Lewis and Clark lake home with lake views and 3 min drive to the beach!
Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake

Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake

Crofton NE
Stay at this cabin in Crofton. Enjoy air conditioning. Popular attractions Deep Water Recreation Area and Lewis and Clark Lake State Recreation Area are located ...
Very nice cabin, very great location, we had a good time there, everyone there very friendly, planning on conning back again

Reviewed on Oct 26, 2025

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Opens in a new windowCozy cabin near Lewis and Clark Lake and CJ’s at the Lake
Overlooks Lewis & Clark Lake/Missouri River Basin-3 Hours Northwest of Omaha

Overlooks Lewis & Clark Lake/Missouri River Basin-3 Hours Northwest of Omaha

Springfield SD
A hot tub is featured at this cabin, along with laundry facilities and barbecue grills.
This house works out perfectly for us. We stay there for hunting in the fall. It has a great kitchen and wonderful views. A big bonus is the large hot tub that looks out over the bluffs to the Missouri River.This is our 2nd year here for our trip and would recommend this for anyone hunting or fishing ...

Reviewed on Nov 7, 2025

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Opens in a new windowOverlooks Lewis & Clark Lake/Missouri River Basin-3 Hours Northwest of Omaha
ThePinecone - luxury vacation rental awesome deck with view & amenities for 2-18

ThePinecone - luxury vacation rental awesome deck with view & amenities for 2-18

Yankton SD
$824 nightly
The price is $866 total per night from Mar 6 to Mar 7
$866 total
Mar 6 - Mar 7
Total with taxes and fees
A hot tub is featured at this vacation home, along with limo/town car service and a garden. Families will appreciate the playground and onsite laundry facilities. ...
The space was very nice for visiting, the kitchen was well equipped except can opener should be trashed and new one gotten. Home was clean and very bright - so many windows. Beds/sleeping was not what was posted on VRBO. Not cleaning the sidewalks and driveway in a timely manner after the snow and ...

Reviewed on Dec 3, 2025

Opens in a new windowThePinecone - luxury vacation rental awesome deck with view & amenities for 2-18
Charming Lake House within Walking Distance from Lake

Charming Lake House within Walking Distance from Lake

Yankton SD
$463 nightly
The price is $486 total per night from Apr 1 to Apr 2
$486 total
Apr 1 - Apr 2
Total with taxes and fees
This vacation home features a garden, laundry facilities, and barbecue grills.
Nice place, lots of space. Different areas to hang out, play games, watch TV. Nice outdoor patio area. Good location, easy access to Lewis & Clark recreation area.

Reviewed on Oct 30, 2025

Opens in a new windowCharming Lake House within Walking Distance from Lake
Lewis and Clark Lake Home/Loft for Rent/Lake View Property and Lake Access

Lewis and Clark Lake Home/Loft for Rent/Lake View Property and Lake Access

Crofton NE
This apartment featured laundry facilities and barbecue grills.
Very clean, to many stirs

Reviewed on Aug 8, 2025

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Opens in a new windowLewis and Clark Lake Home/Loft for Rent/Lake View Property and Lake Access
Spacious Lakeview Cabin Minutes from Private Beach

Spacious Lakeview Cabin Minutes from Private Beach

Crofton NE
This cabin featured laundry facilities and barbecue grills.
The host answered all the multiple questions I had quickly and was very friendly. This place was perfect to get away with friends and family and craft and hang out. There was more than enough space for all eight of us to do our many projects we were working on. Thank you for sharing your home with ...

Reviewed on Feb 23, 2026

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Opens in a new windowSpacious Lakeview Cabin Minutes from Private Beach
Lewis and Clark Resort

Lewis and Clark Resort

2.5 out of 5
43496 Shore Drive Yankton SD
$84 nightly
The price is $89 total per night from Mar 8 to Mar 9
$89 total
Mar 8 - Mar 9
Total with taxes and fees
A marina and a restaurant are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference ...
Perfect spot!

Reviewed on Mar 3, 2026

Opens in a new windowLewis and Clark Resort
Gavins Point Lakehouse

Gavins Point Lakehouse

Yankton SD
This vacation home includes a garden and laundry facilities.
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Opens in a new windowGavins Point Lakehouse
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See all available properties in Santee
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Santee?
From cool amenities to extra space, kid-friendly hotels come with features that can help transform a routine family vacation into a sensational one. These Santee options make vacationing with your youngsters child's play: The whole team will enjoy their time at Private updated hunting lodge/farmhouse. Pet-friendly facilities and a barbecue grill are just a few of the things that help make this property a favorite. Bear Historic Home is another excellent choice. After an exciting day of exploring, come home to your cozy room and amenities like a king bed and animal viewing activities.
Where can I find cheap hotels in Santee?
At Travelocity you'll find really nice hotels in Santee at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Santee rather than in Santee. We may find you even better rates, too.
How do I find the best Santee hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Santee then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Santee?
The cheapest hotel in Santee is $89. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Santee?
There are 58 hotels in Santee on Travelocity.
What are the best hotels in Santee?
Santee has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Santee for you!
When is the best time to visit Santee?
If you want the joy of a fun-filled trip in peak season, visit Santee during May, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Santee?
Based on historic data is usually the cheapest month to visit Santee. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Santee?
There are multiple hotels in Santee that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Santee. We have plenty of kid-friendly hotels in Santee to choose from on Travelocity!
Why book a hotel in Santee through Travelocity?
Because we have the top hotels in Santee! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Santee on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Santee hotel reviews by fellow wanderers

Lewis and Clark Resort

Lewis and Clark Resort

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Perfect spot!"
A verified traveler stayed at Lewis and Clark Resort
Lewis and Clark Resort

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