
Exclusive Mississippi River Vacation Deals

Mississippi River vacation package deals
Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel
Save 100% on your flight
Price was $654, price is now $372 per person
$372
per person
Mar 20 - Mar 23
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

The Emily Hotel
Downtown Chicago
Save 100% on your flight
Price was $662, price is now $378 per person
$378
per person
Feb 26 - Mar 1
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Chicago (ORD)
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. A coffee shop, a snack bar/deli, and luggage storage are also on offer.

Latitude Apartments
Save 100% on your flight
Price was $1,025, price is now $594 per person
$594
per person
Feb 15 - Feb 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to New Orleans (MSY)
This apartment features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Self parking, a free grocery shopping service, and a grocery/convenience store are also offered.

Hotel Riu Plaza Chicago
Downtown Chicago
Save 100% on your flight
Price was $657, price is now $386 per person
$386
per person
Mar 4 - Mar 8
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Chicago (ORD)
This hotel features 2 bars/lounges and a 24-hour gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy a meal from the restaurant and free buffet breakfast each morning.

Horseshoe Tunica- A Caesars Rewards Destination
Price was $1,053, price is now $624 per person
$624
per person
Mar 16 - Mar 20
found 21 hours ago
Roundtrip flight included
Detroit (DTW) to Memphis (MEM)
A casino, 5 restaurants, and a 24-hour gym are all featured at this hotel. Free self parking is free for guests, and you can enjoy a meal in one of the 2 coffee shops/cafes. You'll appreciate the seasonal outdoor pool, bar/lounge, and snack bar/deli.

Trump International Hotel & Tower Chicago
Downtown Chicago
Save 100% on your flight
Price was $990, price is now $589 per person
$589
per person
Mar 18 - Mar 21
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Chicago (ORD)
A full-service spa, an indoor pool, and a restaurant are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly dining, and in-room childcare. Enjoy the gym and perks like free WiFi.
Frequently asked questions
Top Mississippi River hotel deals

Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
Free Cancellation
Reserve now, pay when you stay
$99 nightly
The price is $117 total per night
$117 total
Dec 30 - Dec 31
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. There's a rooftop terrace on site, and a 24-hour front desk and a coffee shop are also provided.
Pet friendly
Free WiFi

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
333 Washington Ave St. Louis MO
Free Cancellation
Reserve now, pay when you stay
$98 nightly
The price is $114 total per night
$114 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
Pool
Breakfast included

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
421 N 8th St St. Louis MO
Free Cancellation
Reserve now, pay when you stay
$97 nightly
The price is $115 total per night
$115 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. A coffee shop, a snack bar/deli, and a communal living room are also on offer.
Pet friendly
Free WiFi
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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