Book Hotels in Upstate South Carolina, SC

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Top Upstate South Carolina hotels

Hotel Hartness

Hotel Hartness

4 out of 5
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $191 total per night from Apr 5 to Apr 6
$191 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
We stayed overnight for an appointment the next day in the area. It was a lovely stay. We had drinks & lunch in the bar but went out to dinner because it was Sunday and the restaurant was closed. The food and service in the bar area were great! My complaint is that we left clothes in the closet and ...

Reviewed on Mar 14, 2026

Opens in a new windowHotel Hartness
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$298 nightly
The price is $327 total per night from Mar 17 to Mar 18
$327 total
Mar 17 - Mar 18
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...
Perfectly located to walk to the river, downtown and peace center. Gorgeous asthetic, and pristine rooms, we loved the restaurant also! Staff we courteous and helpful in everyway. 10/10

Reviewed on Mar 2, 2026

Opens in a new windowGrand Bohemian Lodge Greenville, Autograph Collection
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $97 total per night from Mar 29 to Mar 30
$97 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Goid breakfast variety. Would stay there again.

Reviewed on Mar 16, 2026

Opens in a new windowBest Western Plus Greenville I-385 Inn & Suites
Hyatt Place Greenville Downtown

Hyatt Place Greenville Downtown

3 out of 5
128 East Broad Street Greenville SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Mar 29 to Mar 30
$153 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
The girl who checked in was super nice and helpful.

Reviewed on Mar 15, 2026

Opens in a new windowHyatt Place Greenville Downtown
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $118 total per night from Apr 5 to Apr 6
$118 total
Apr 5 - Apr 6
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
The breakfast is outstanding Quin managed multiple omelet orders with grace and accuracy. The suite was wonderful and quiet.

Reviewed on Mar 15, 2026

Opens in a new windowEmbassy Suites Greenville Golf Resort & Conference Center
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $163 total per night from Mar 29 to Mar 30
$163 total
Mar 29 - Mar 30
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
Great location, very nice staff.

Reviewed on Mar 10, 2026

Opens in a new windowHyatt Regency Greenville
Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $109 total per night from Mar 22 to Mar 23
$109 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
Room was very clean and comfortable. Environment felt safe. Only issue was some of the staff members at the front desk (white ladies) seem to be a bit racist when a person of color is checking in. Acting as if I don’t belong there or something. But my trip was still great and enjoyed the comfort ...

Reviewed on Mar 15, 2026

Opens in a new windowHilton Greenville
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $110 total per night from Mar 17 to Mar 18
$110 total
Mar 17 - Mar 18
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
Clean room/friendly staff/good breakfast

Reviewed on Mar 14, 2026

Opens in a new windowBest Western Plus Clemson Hotel & Conference Center
Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

3 out of 5
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $103 total per night from Mar 30 to Mar 31
$103 total
Mar 30 - Mar 31
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
parking was easy, the room was clean and staff was courteous and efficient

Reviewed on Mar 16, 2026

Opens in a new windowHyatt Place Greenville/Haywood
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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