Find and compare 2 Star hotels in Upstate South Carolina

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Next weekend
In two weeks

Top Upstate South Carolina 2 Star hotels

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd Anderson SC
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $70 total per night from Feb 1 to Feb 2
$70 total
Feb 1 - Feb 2
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
7.8/10 Good! (1,009 reviews)
The room was spotless, the property well kept, the staff was kind and helpful and the location was great!

Reviewed on Jan 22, 2026

Opens in a new windowDays Inn by Wyndham Anderson
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $85 total per night from Feb 1 to Feb 2
$85 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
9/10 Wonderful! (1,429 reviews)
Yes

Reviewed on Jan 19, 2026

Opens in a new windowBest Western Plus Greenville I-385 Inn & Suites
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Jan 27 to Jan 28
$105 total
Jan 27 - Jan 28
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
8.2/10 Very Good! (1,001 reviews)
Rooms are clean. Staff was very pleasant.

Reviewed on Jan 20, 2026

Opens in a new windowBest Western Plus Clemson Hotel & Conference Center
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $92 total per night from Feb 1 to Feb 2
$92 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
7.8/10 Good! (670 reviews)
Our stay was very nice. Clean room. The outside was clean.

Reviewed on Jan 20, 2026

Opens in a new windowQuality Inn Seneca Clemson Area US-123
ECHO Suites Extended Stay by Wyndham Spartanburg

ECHO Suites Extended Stay by Wyndham Spartanburg

2 out of 5
490 W Blackstock Road Spartanburg SC
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $85 total per night from Feb 1 to Feb 2
$85 total
Feb 1 - Feb 2
Total with taxes and fees
A 24-hour gym, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Staff at the 24-hour front desk can provide ...
8/10 Very Good! (329 reviews)
Room was clean and beds were comfortable. It would have been nice if you supplied pans and dishes and not make the guest pay for them. I bought my own pan and spoon to makes stuff with. That was the only con. Will be staying again

Reviewed on Jan 19, 2026

Opens in a new windowECHO Suites Extended Stay by Wyndham Spartanburg
Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

2 out of 5
1024 Woodruff Rd Greenville SC
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $76 total per night from Feb 9 to Feb 10
$76 total
Feb 9 - Feb 10
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...
8.2/10 Very Good! (1,001 reviews)
Nice people very clean

Reviewed on Jan 20, 2026

Opens in a new windowMicrotel Inn & Suites by Wyndham Greenville / Woodruff Rd
Comfort Suites Greenville Airport

Comfort Suites Greenville Airport

2.5 out of 5
1371 Garlington Road Greenville SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $111 total per night from Feb 8 to Feb 9
$111 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
9.2/10 Wonderful! (1,011 reviews)
The room was clean. Marie at the from desk was exceptionally accommodate. We felt welcome as soon as we walked in. The breakfast was sufficient. Although, the closed 5 minutes before 9 and wouldn’t allow a couple to even quickly grab something. Would definitely stay here again.

Reviewed on Jan 24, 2026

Opens in a new windowComfort Suites Greenville Airport
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Feb 2 to Feb 3
$106 total
Feb 2 - Feb 3
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
8.2/10 Very Good! (1,000 reviews)
Clean room. Friendly staff. Convenient location.

Reviewed on Jan 17, 2026

Opens in a new windowComfort Inn & Suites Clemson - University Area
Motel 6 Greenville, SC

Motel 6 Greenville, SC

2 out of 5
2015 Wade Hampton Blvd Greenville SC
$50 nightly
The price is $55 total per night from Jan 26 to Jan 27
$55 total
Jan 26 - Jan 27
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...
5.2/10 (751 reviews)
staff was amazingly friendly and helpful

Reviewed on Jan 22, 2026

Opens in a new windowMotel 6 Greenville, SC
Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall

2.5 out of 5
246 Congaree Road Greenville SC
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $97 total per night from Jan 26 to Jan 27
$97 total
Jan 26 - Jan 27
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
8/10 Very Good! (1,000 reviews)
Staff was very nice.Only thing that stoodout was the sound of water dripping and my room was on the 3rd floor. No ice machine on the floor. The hotel was very clean a d l would recommend the hotel to others.

Reviewed on Jan 15, 2026

Opens in a new windowComfort Inn Greenville - Haywood Mall
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

2 Star Hotels Upstate South Carolina

Looking to break out of your routine for some much needed rest and relaxation? Or maybe you’ve already decided it’s time for a trip and are trying to find affordable hotels in Upstate South Carolina that won’t bust your travel budget?

Upstate South Carolina 2 star hotels will give you everything you need to enjoy the city like a local, saving a ton of money so you can hit all the hot spots in town.

Have a delicious breakfast at your hotel to fuel up for your day of sightseeing, then enjoy amenities like fresh towels and linens, as well as a nice hot shower to unwind after a busy day of experiencing everything the city has to offer.

As you explore a new locale, or one you love to visit over and over, you can rest easy knowing you’re staying in a great hotel that lets you discover Upstate South Carolina and welcomes you back to a clean, comfortable room at night.

Browse Travelocity’s wide selection of 2 star hotels in Upstate South Carolina and find one that’s perfectly priced and places you next to all the best activities and sights. The town is your oyster, and we can help you seek out its secrets while sticking to your budget.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity