Explore top 2025 4 Star Hotels in Upstate South Carolina

Name: Hotel Domestique
Price range: $450 total
Rating: 9.6

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Top Upstate South Carolina 4 Star hotels

Grand Bohemian Lodge Greenville, Autograph Collection

44 EAST CAMPERDOWN WAY, Greenville, SC

Fully refundableReserve now, pay when you stay

$276 nightly

$304 total

Nov 30 - Dec 1

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...

9.4/10 Exceptional! (403 reviews)

Chip and his staff is the best!!

Reviewed on Nov 7, 2025

The Shepherd Hotel Downtown Clemson

110 Sloan St, Clemson, SC

Fully refundableReserve now, pay when you stay

$169 nightly

$188 total

Dec 7 - Dec 8

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...

9.6/10 Exceptional! (720 reviews)

First, but definitely not last stay

Our room, although small, was lovely and spotless. Bed linens were soft and cozy.

Reviewed on Oct 25, 2025

The Westin Poinsett Greenville

120 South Main St, Greenville, SC

Fully refundableReserve now, pay when you stay

$169 nightly

$186 total

Nov 24 - Nov 25

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...

9.2/10 Wonderful! (1,002 reviews)

Reviewed on Nov 9, 2025

Hotel Hartness

120 Halston Avenue, Greenville, SC

Fully refundableReserve now, pay when you stay

$199 nightly

$219 total

Nov 19 - Nov 20

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...

9.8/10 Exceptional! (612 reviews)

Staff was professional and courteous. Amazing room and resort amenities.

Reviewed on Nov 11, 2025

Greenville Marriott

One Parkway E, Greenville, SC

Fully refundableReserve now, pay when you stay

$105 nightly

$116 total

Nov 28 - Nov 29

Total with taxes and fees

This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-in, ...

8.4/10 Very Good! (603 reviews)

Staff were friendly and helpful. Breakfast was good. Location was good. The property is reaching a point were it could use a refresh.

Reviewed on Oct 12, 2025

Mint House Greenville - Downtown

101 Falls Park Dr, Greenville, SC

$123 nightly

$134 total

Nov 30 - Dec 1

Total with taxes and fees

A 24-hour gym, self parking, and laundry facilities are featured at this apartment. Express check-in and express check-out are also provided.

9.2/10 Wonderful! (761 reviews)

Great location. Easy check-in/check-out. Questions answered promptly via phone call or text. Plenty of room and privacy for guests.

Reviewed on Nov 7, 2025

The Abernathy of Clemson

157 Old Greenville Hwy, Clemson, SC

$142 nightly

$158 total

Dec 3 - Dec 4

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...

9.6/10 Exceptional! (550 reviews)

location is amazing!

Reviewed on Nov 1, 2025

Park Place Apartments by Landing

31 Victor St, Greenville, SC

This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A 24-hour gym and a virtual front desk are also provided.

7.6/10 Good! (40 reviews)

Great access to bike trail. No working elevator and 3 flights of stairs with luggage is a challenge.

Reviewed on Jun 19, 2025

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Liberty Hall Bed and Breakfast

621 S Mechanic St, Pendleton, SC

$213 nightly

$236 total

Nov 20 - Nov 21

Total with taxes and fees

This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the free full breakfast each morning. A garden, express ...

9.8/10 Exceptional! (76 reviews)

The owners are amazing. Comfy rooms, stellar breakfast and good people.

Reviewed on Nov 9, 2025

Hotel Domestique

10 Road of Vines, Travelers Rest, SC

$409 nightly

$450 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features a restaurant, an outdoor tennis court, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like cooked-to-order breakfast and ...

9.6/10 Exceptional! (30 reviews)

Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away.

Reviewed on Jul 27, 2025

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4 Star Hotels Upstate South Carolina

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Upstate South Carolina 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Upstate South Carolina will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Upstate South Carolina, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.