Deals on vacations and trips to Mesopotamia

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Mesopotamia flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.
The Excelsior Small Luxury Hotels of the World

The Excelsior Small Luxury Hotels of the World

5 out of 5
Thessaloniki City Centre
Price was $1,427, price is now $1,229 per person
$1,229
per person
Feb 16 - Feb 22
found 1 day ago
Roundtrip flight included
Philadelphia (PHL) to Thessaloniki (SKG)
A restaurant and a bar/lounge are featured at this hotel. Guests will appreciate free perks like buffet breakfast and WiFi in public areas. A business center, a coffee shop, and a snack bar/deli are also on offer.
Daios Luxury Living

Daios Luxury Living

5 out of 5
Thessaloniki City Centre
Price was $1,683, price is now $1,421 per person
$1,421
per person
Feb 16 - Feb 22
found 1 day ago
Roundtrip flight included
Philadelphia (PHL) to Thessaloniki (SKG)
A restaurant and a bar/lounge are featured at this hotel. Families will appreciate the onsite laundry facilities and in-room childcare. Guests will appreciate free perks like buffet breakfast and WiFi in public areas.
ON Residence

ON Residence

5 out of 5
Thessaloniki City Centre
Price was $1,481, price is now $1,261 per person
$1,261
per person
Feb 16 - Feb 22
found 1 day ago
Roundtrip flight included
Philadelphia (PHL) to Thessaloniki (SKG)
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and airport shuttle. Enjoy the free buffet breakfast each morning.
ONOMA Hotel

ONOMA Hotel

5 out of 5
Vardaris
Price was $1,536, price is now $1,313 per person
$1,313
per person
Feb 16 - Feb 22
found 1 day ago
Roundtrip flight included
Philadelphia (PHL) to Thessaloniki (SKG)
This hotel features a restaurant, a gym, and a bar/lounge. There's fun for all ages with a playground and an arcade/game room, and in-room childcare is an added bonus. Enjoy the seasonal outdoor pool and perks like free WiFi.
Vanoro Hotel

Vanoro Hotel

5 out of 5
Thessaloniki City Centre
Price was $1,520, price is now $1,322 per person
$1,322
per person
Feb 16 - Feb 22
found 1 day ago
Roundtrip flight included
Philadelphia (PHL) to Thessaloniki (SKG)
A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and airport shuttle. Relax with a drink at the bar/lounge and enjoy the free cooked-to-order breakfast each morning.

Top Mesopotamia hotels deals

To Spiti tis Sofias

To Spiti tis Sofias

Mesopotamia Kastoria Western Macedonia
$67 nightly
The price is $77 total per night
$77 total
Jan 26 - Jan 27, 2026
Total with taxes and fees
This guesthouse doesn't skimp on freebies - guests receive free WiFi and free self parking. A garden, a lobby fireplace, and a communal living room are also on offer.
Parking included
Free WiFi
Limneon Resort & Spa

Limneon Resort & Spa

4 out of 5
4th km National Road Kastoria Athens Kastoria
Free Cancellation
Reserve now, pay when you stay
$100 nightly
The price is $118 total per night
$118 total
Jan 12 - Jan 13, 2026
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling for business? Take advantage of the free WiFi in public areas, laundry service, and conference center. Enjoy a meal in one of the 3 coffee shops/cafes and perks like free buffet breakfast and free self parking.
Pool
Breakfast included
Hotel Anastassiou

Hotel Anastassiou

2 out of 5
1st km Highway Kastoria-Athens Kastoria Western Macedonia
Get rates
A restaurant and a bar/lounge are featured at this hotel. Enjoy the ski shuttle and onsite ski storage. There's no skimping on freebies - guests receive free WiFi, free valet parking, and a free airport shuttle.
Free airport shuttle
Parking included
Chloe Hotel

Chloe Hotel

3 out of 5
Antheon & Giasemion Kastoria Western Macedonia
$102 nightly
The price is $118 total per night
$118 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
An attached winery and an outdoor tennis court are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and airport shuttle. Enjoy a meal from the restaurant and perks like free buffet breakfast and free self parking.
Breakfast included
Spa
Esperos Palace Luxury & Spa Hotel

Esperos Palace Luxury & Spa Hotel

4 out of 5
Chloe Area Kastoria Western Macedonia
Get rates
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Hot Tub
Calma Hotel & Spa

Calma Hotel & Spa

4 out of 5
3rd km Kastoria Kastoria
Get rates
A full-service spa and a gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and airport shuttle. Enjoy the seasonal outdoor pool and free perks like buffet breakfast and free self parking.
Pool
Breakfast included
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See all available properties in Mesopotamia
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Kastoria Lake

Commune with nature and explore the great outdoors at Kastoria Lake during your travels in Kastoria. While you're in the area, stroll along the lakeside.

Kastoria Lake

Kastoria Aquarium

Make time in your itinerary to visit the sea life who live at Kastoria Aquarium during your visit to Kastoria. While you're in the area, stroll along the lakeside.

Kastoria Aquarium

Dragon's Lair

Explore the great outdoors at Dragon's Lair, a lovely green space in Kastoria. While you're in the area, stroll along the lakeside.

Dragon's Lair

Frequently asked questions

How much are vacation packages to Mesopotamia?
Travelocity offers great package deals to Mesopotamia, including hotels and flights, starting at just $1,229. With all the cash you save, you could book some cool tours or maybe even tack on a few extra days to your adventure.
Where can I get the best vacation package deals for Mesopotamia?
There are awesome Mesopotamia package deals to be snapped up with Travelocity. Did you know we partner with 400 airlines and 1,000,000 properties in all corners of the globe? Keep this in mind the next time you're ready to tick another place off your bucket list.
Why should I book my Mesopotamia vacation package with Travelocity?
Because you'll never wander alone if you book your vacation with us, and we offer round-the-clock support and exceptional service to boot. Add to that our Price Match Guarantee and a massive range of experiences and destinations to select from. It's our job to help you jet off on the vacation of a lifetime.
Will I save money on my Mesopotamia car rental if I combine it with hotels and flights?
Combining your car, hotel and flight into a Mesopotamia vacation package is the easiest way to land the best prices. Plus, having your own wheels gives you total freedom to find your way to all those big-name sights you can't wait to explore. Located 95 mi from Mesopotamia, White Tower of Thessaloniki is one attraction that should feature on your itinerary. Top up the tank and make a day trip of it.
Which airport is best for Mesopotamia?
Ioannina National Airport (IOA), located around 60 mi south of downtown Mesopotamia, is likely to be where you'll jet into. Your other options are Kastoria (KSO-Aristoteles) (7 mi away from central Mesopotamia) and Kozani (KZI-Filippos) (40 mi away from central Mesopotamia).
Where should I stay when visiting Mesopotamia?
The To Spiti tis Sofias is recommended by many visitors. Book soon to avoid missing out.

Photos of local treasures

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