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Top Mesopotamia hotels
To Spiti tis Sofias
"Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin."
Reviewed on Aug 18, 2025
Guest House Ilektra
"Friendly and courteous hosts, great food and excellent service"
Reviewed on Dec 29, 2025
Calma Hotel & Spa
"If you’re looking for a hotel, that is clean, spacious, warm and inviting this is the place for you. It has the perfect location to be out of the way but close enough to all of Kastoria and surrounding villages. Staff were kind and exceptional. Everyone was extremely helpful, courteous and made us ..."
Reviewed on Aug 6, 2026
Orologopoulos Mansion
"This was a nice enough hotel but is described as a five star, luxury hotel (as detailed on the Hotel.com website). It is three stars at best. The junior was fairly basic, did not have a sofa, had poor lighting and a was bit tired with the bathroom being very dated and in need of regrouting, etc. ..."
Reviewed on Aug 4, 2026
Limneon Resort & Spa
"We loved our stay very much and will definitely be returning from the staff to the location and simply beautiful views we couldn’t ask for anything better the only suggestion is that they add dresser’s with draws so you can putt your cloths out instead of having to use your suit cases."
Reviewed on Aug 10, 2026
Esperos Palace Luxury & Spa Hotel
"The hotel is beautiful, large room with balcony. Grate bathroom, comfortable, the dinner is good ,however the breakfast was amazing."
Reviewed on Sep 4, 2025
Hotel Anastassiou
Chloe Hotel
Le Marron
Mesopotamia Hotel & Travel Guide\n
Are you planning to have some nights in Western Macedonia? Hoping to reserve somewhere to stay in the Mesopotamia area? Within an easy commute to the Mesopotamia CBD, travelers will find 2 modern lodging options.
Within a short drive of Mesopotamia, are the Hotel Nostos and Esperos Palace.
The Kyknos De Luxe Suites is located 5 miles (9 kilometers) from the central part of Mesopotamia. Or, alternatively, the Villa Del Lago is 7 miles (11 kilometers) away. An alternative option is to make a reservation at the Afkos Grammos Luxury Boutique Hotel or the Allahou.
After you've enjoyed Mesopotamia, make the trip to soak up the other cultural and scenic attractions of the Greek Mainland area. Greek Mainland is known for beaches, coastal plains and rivers. Interesting holiday attractions include castles. Common activities in this particular part of Greece include snowboarding and skiing.
The nearest accommodations in Western Macedonia include Kastoria and Aposkepos. Kastoria is 5 miles (8 kilometers) to the northeast of Mesopotamia, while Aposkepos is 6 miles (9 kilometers) to the northeast. Lodgings in Kastoria include the Hotel Anastassiou and Hotel Keletron. The Akropolis and Chloe Hotel are a selection of the Travelocity-registered accommodation options in Aposkepos.
After you have checked out the available hotel options in Mesopotamia, make sure you discover our Mesopotamia city page for the low-down on ways to spend your time in this area.
Frequently asked questions
Recent Mesopotamia hotel reviews by fellow wanderers
Limneon Resort & Spa
"We loved our stay very much and will definitely be returning from the staff to the location and simply beautiful views we couldn’t ask for anything better the only suggestion is that they add dresser’s with draws so you can putt your cloths out instead of having to use your suit cases."
