Book Hotels in Mesopotamia

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Mesopotamia hotels

To Spiti tis Sofias

To Spiti tis Sofias

Mesopotamia Kastoria Western Macedonia
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $82 total per night from Mar 1 to Mar 2
$82 total
Mar 1 - Mar 2
Total with taxes and fees
This guesthouse doesn't skimp on freebies - guests receive free WiFi and free self parking. A garden, a lobby fireplace, and a communal living room are also ...
Le meilleur de notre séjour
Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin.

Reviewed on Aug 18, 2025

Opens in a new windowTo Spiti tis Sofias
Guesthouse Monopati

Guesthouse Monopati

Lechovo Amyntaio Florina
A restaurant and a snack bar/deli are featured at this guesthouse. Enjoy the free local cuisine breakfast each morning.
Opens in a new windowGuesthouse Monopati
Chloe Hotel

Chloe Hotel

3 out of 5
Antheon & Giasemion Kastoria Western Macedonia
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $120 total per night from Feb 23 to Feb 24
$120 total
Feb 23 - Feb 24
Total with taxes and fees
An attached winery and an outdoor tennis court are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Romantic and special. Highly recommend. Kastoria is a rare find. This hotel is a great getaway.

Reviewed on Jun 26, 2025

Opens in a new windowChloe Hotel
Calma Hotel & Spa

Calma Hotel & Spa

4 out of 5
3rd km Kastoria Kastoria
Fully refundableReserve now, pay when you stay
A full-service spa and a gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and airport ...
We arrived off season , We felt like the hotel was in a sleepy mood, we arrived late and although the reception was working all the lights at the loby where shut. In general it felt like the hotel has great potential, but even the pool was drained. The breakfast was served in a very small portions ...

Reviewed on Oct 17, 2025

Opens in a new windowCalma Hotel & Spa
Limneon Resort & Spa

Limneon Resort & Spa

4 out of 5
4th km National Road Kastoria Athens Kastoria
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $123 total per night from Feb 23 to Feb 24
$123 total
Feb 23 - Feb 24
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling for business? Take advantage of the free WiFi in ...
This is an incredible hotel for families - child friendly, clean, and wonderful facilities. There is a small indoor play zone with someone who looks after the kids. The breakfast buffet is fantastic. The indoor pool is lovely. Everyone that works here is the kindest! My family and I had a wonderful ...

Reviewed on Jan 22, 2026

Opens in a new windowLimneon Resort & Spa
Esperos Palace Luxury & Spa Hotel

Esperos Palace Luxury & Spa Hotel

4 out of 5
Chloe Area Kastoria Western Macedonia
Fully refundableReserve now, pay when you stay
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
The hotel is beautiful, large room with balcony. Grate bathroom, comfortable, the dinner is good ,however the breakfast was amazing.

Reviewed on Sep 4, 2025

Opens in a new windowEsperos Palace Luxury & Spa Hotel
Hotel Anastassiou

Hotel Anastassiou

2 out of 5
1st km Highway Kastoria-Athens Kastoria Western Macedonia
A restaurant and a bar/lounge are featured at this hotel. Enjoy the ski shuttle and onsite ski storage. There's no skimping on freebies - guests receive free ...
Nice simple stay.

Reviewed on Mar 13, 2025

Opens in a new windowHotel Anastassiou
Hotel Kastoria

Hotel Kastoria

3 out of 5
NIKIS AVENUE 122 Kastoria
Free self parking is available and the hotel's multilingual staff can provide around-the-clock assistance. WiFi in public areas is free. A snack bar/deli, express ...
Excellent position by the lake. Good room but old bathroom with a small shower. Variety at breakfast but expensive for 10 euros per person.

Reviewed on Oct 20, 2023

Opens in a new windowHotel Kastoria
Guesthouse Vissinokipos

Guesthouse Vissinokipos

Aposkepos, Western Macedonia Kastoria
A bar/lounge and a coffee shop are featured at this guesthouse, along with free self parking. Guests will appreciate free perks like buffet breakfast and WiFi ...
Lovely view.

Reviewed on Sep 11, 2023

Opens in a new windowGuesthouse Vissinokipos
Don't see what you're looking for?
See all available properties in Mesopotamia
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Mesopotamia Hotel & Travel Guide\n

Are you planning to have some nights in Western Macedonia? Hoping to reserve somewhere to stay in the Mesopotamia area? Within an easy commute to the Mesopotamia CBD, travelers will find 2 modern lodging options.

Within a short drive of Mesopotamia, are the Hotel Nostos and Esperos Palace.

The Kyknos De Luxe Suites is located 5 miles (9 kilometers) from the central part of Mesopotamia. Or, alternatively, the Villa Del Lago is 7 miles (11 kilometers) away. An alternative option is to make a reservation at the Afkos Grammos Luxury Boutique Hotel or the Allahou.

After you've enjoyed Mesopotamia, make the trip to soak up the other cultural and scenic attractions of the Greek Mainland area. Greek Mainland is known for beaches, coastal plains and rivers. Interesting holiday attractions include castles. Common activities in this particular part of Greece include snowboarding and skiing.

The nearest accommodations in Western Macedonia include Kastoria and Aposkepos. Kastoria is 5 miles (8 kilometers) to the northeast of Mesopotamia, while Aposkepos is 6 miles (9 kilometers) to the northeast. Lodgings in Kastoria include the Hotel Anastassiou and Hotel Keletron. The Akropolis and Chloe Hotel are a selection of the Travelocity-registered accommodation options in Aposkepos.

After you have checked out the available hotel options in Mesopotamia, make sure you discover our Mesopotamia city page for the low-down on ways to spend your time in this area.

Frequently asked questions

What are the top kid-friendly hotels in Mesopotamia?
Take some of the challenges out of traveling with little ones by staying in a family-friendly Mesopotamia hotel. From special amenities to more services, these properties come with perks that'll make your visit plain sailing: Hotel Nostos will help make your break the most memorable one yet. It comes with a host of conveniences aimed at families, such as a cafe and express check-out services. Also look up Anesis Hotel. It offers front desk services, room service and plenty of opportunities to hang out as a family.
Where can I find cheap hotels in Mesopotamia?
At Travelocity you'll find really nice hotels in Mesopotamia at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Mesopotamia rather than in Mesopotamia. We may find you even better rates, too.
How do I find the best Mesopotamia hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Mesopotamia then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Mesopotamia?
The cheapest hotel in Mesopotamia is $82. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Mesopotamia?
There are 47 hotels in Mesopotamia on Travelocity.
What are the best hotels in Mesopotamia?
Mesopotamia has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Mesopotamia for you!
When is the best time to visit Mesopotamia?
If you want the joy of a fun-filled trip in peak season, visit Mesopotamia during May, August and September. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Mesopotamia?
Based on historic data is usually the cheapest month to visit Mesopotamia. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Mesopotamia?
There are multiple hotels in Mesopotamia that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Mesopotamia. We have plenty of kid-friendly hotels in Mesopotamia to choose from on Travelocity!
Why book a hotel in Mesopotamia through Travelocity?
Because we have the top hotels in Mesopotamia! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Mesopotamia on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Mesopotamia hotel reviews by fellow wanderers