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Top Mesopotamia hotels
To Spiti tis Sofias
"Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin."
Reviewed on Aug 18, 2025
Guest House Ilektra
"Friendly and courteous hosts, great food and excellent service"
Reviewed on Dec 29, 2025
Calma Hotel & Spa
"We arrived off season , We felt like the hotel was in a sleepy mood, we arrived late and although the reception was working all the lights at the loby where shut. In general it felt like the hotel has great potential, but even the pool was drained. The breakfast was served in a very small portions ..."
Reviewed on Oct 17, 2025
Orologopoulos Mansion
"This is the hotel we return to time and time again, and the one we are never disappointed by. * Clean: Perfectly clean. Daily refresh of linens and tidying of room. Public spaces pristine. Black out shades were a pleasant surprise in an antique building like this one. Loved that touch! * Customer ..."
Reviewed on Jul 15, 2026
Esperos Palace Luxury & Spa Hotel
"The hotel is beautiful, large room with balcony. Grate bathroom, comfortable, the dinner is good ,however the breakfast was amazing."
Reviewed on Sep 4, 2025
Limneon Resort & Spa
Hotel Anastassiou
Chloe Hotel
Le Marron
Mesopotamia Hotel & Travel Guide\n
Are you planning to have some nights in Western Macedonia? Hoping to reserve somewhere to stay in the Mesopotamia area? Within an easy commute to the Mesopotamia CBD, travelers will find 2 modern lodging options.
Within a short drive of Mesopotamia, are the Hotel Nostos and Esperos Palace.
The Kyknos De Luxe Suites is located 5 miles (9 kilometers) from the central part of Mesopotamia. Or, alternatively, the Villa Del Lago is 7 miles (11 kilometers) away. An alternative option is to make a reservation at the Afkos Grammos Luxury Boutique Hotel or the Allahou.
After you've enjoyed Mesopotamia, make the trip to soak up the other cultural and scenic attractions of the Greek Mainland area. Greek Mainland is known for beaches, coastal plains and rivers. Interesting holiday attractions include castles. Common activities in this particular part of Greece include snowboarding and skiing.
The nearest accommodations in Western Macedonia include Kastoria and Aposkepos. Kastoria is 5 miles (8 kilometers) to the northeast of Mesopotamia, while Aposkepos is 6 miles (9 kilometers) to the northeast. Lodgings in Kastoria include the Hotel Anastassiou and Hotel Keletron. The Akropolis and Chloe Hotel are a selection of the Travelocity-registered accommodation options in Aposkepos.
After you have checked out the available hotel options in Mesopotamia, make sure you discover our Mesopotamia city page for the low-down on ways to spend your time in this area.
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Recent Mesopotamia hotel reviews by fellow wanderers
Orologopoulos Mansion
"This is the hotel we return to time and time again, and the one we are never disappointed by. * Clean: Perfectly clean. Daily refresh of linens and tidying of room. Public spaces pristine. Black out shades were a pleasant surprise in an antique building like this one. Loved that touch! * Customer service. Top-tier service. Warm and friendly but also give space. * Breakfast. Delicious pites, pastries, yogurt. Choice of barista-quality coffees. Lovely space to eat, both inside and outside in their private garden. * Location. One block from the lake (GREAT for jogging) and across the street from the plateia (square), with its choice of chic restaurants. Quiet when you need it to be. * Parking. Right in front every day, with no issue whatsoever. Always a perfect stay. Love this hotel!"
