Book Hotels in Lyon, MS

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Lyon hotels

The Governors Mansion in Clarksdale Mississippi. A Step Back in Time

The Governors Mansion in Clarksdale Mississippi. A Step Back in Time

Clarksdale MS
An outdoor pool is featured at this villa, along with laundry facilities.
Great stay!
We rented this house for my mother in law’s 80th birthday. The house was perfect! There was plenty of room for everyone to relax and socialize. This home is very comfortable and so beautiful! We thoroughly enjoyed our weekend!

Reviewed on Jun 30, 2025

Get rates
Opens in a new windowThe Governors Mansion in Clarksdale Mississippi. A Step Back in Time
Only a mile from historic downtown Clarksdale!

Only a mile from historic downtown Clarksdale!

Clarksdale MS
$184 nightly
The price is $196 total per night from Feb 17 to Feb 18
$196 total
Feb 17 - Feb 18
Total with taxes and fees
An outdoor pool is featured at this cottage, along with laundry facilities and barbecue grills.
The cottage was excellent. I would recommend staying there.

Reviewed on Oct 23, 2025

Opens in a new windowOnly a mile from historic downtown Clarksdale!
Sunset Log Cabin

Sunset Log Cabin

Clarksdale MS
$173 nightly
The price is $186 total per night from Feb 17 to Feb 18
$186 total
Feb 17 - Feb 18
Total with taxes and fees
This cabin features barbecue grills.
A true cabin experience but feels comfortable like home. It is close to the road but I was able to tune out the car noises. The view of sunset is amazing even in the winter time with the already harvested cotton field. All the necessary accessories are provided and very close to town. I’d suggest ...

Reviewed on Dec 20, 2025

Opens in a new windowSunset Log Cabin
Travelers Hotel

Travelers Hotel

2.5 out of 5
212 3rd St Clarksdale MS
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $169 total per night from Mar 19 to Mar 20
$169 total
Mar 19 - Mar 20
Total with taxes and fees
A bar/lounge and a fireplace in the lobby are featured at this hotel, along with free self parking. WiFi in public areas is free. Luggage storage is also ...
Very nice,

Reviewed on Jan 6, 2026

Opens in a new windowTravelers Hotel
Auberge Clarksdale Blues Hostel

Auberge Clarksdale Blues Hostel

2 out of 5
164 Delta Ave Clarksdale MS
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $132 total per night from Feb 17 to Feb 18
$132 total
Feb 17 - Feb 18
Total with taxes and fees
Free WiFi in public areas, a communal living room, and express check-out are available at this hostel. Dry cleaning, luggage storage, and locker space are also ...
The room was clean and bathroom was clean. There was a party the night I was there that I could hear in my room. I was able to sleep through most of it but between 1 and 3 it sounded like they were in the room with me

Reviewed on Feb 8, 2026

Opens in a new windowAuberge Clarksdale Blues Hostel
The Sunflower Penthouse on the River in Clarksdale

The Sunflower Penthouse on the River in Clarksdale

Clarksdale MS
$199 nightly
The price is $213 total per night from Feb 22 to Feb 23
$213 total
Feb 22 - Feb 23
Total with taxes and fees
This vacation home features a garden, laundry facilities, and barbecue grills.
Still nice
I like this spot. It's out of the way of all of the hustle and bustle, but still just a few minutes away from downtown and the main drag. There is a nice view of the Sunflower river and lots of space to roam around out back if you're adventurous.The seating in the living room needs to be cleaned. ...

Reviewed on Aug 11, 2025

Opens in a new windowThe Sunflower Penthouse on the River in Clarksdale
Hampton Inn Clarksdale

Hampton Inn Clarksdale

2.5 out of 5
15000 New Africa Rd Clarksdale MS
Fully refundableReserve now, pay when you stay
$136 nightly
The price is $148 total per night from Feb 22 to Feb 23
$148 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Our room was very nice and the young lady at the desk was informative and friendly. I would definitely stay here again if I find myself back in Clarksdale.

Reviewed on Feb 8, 2026

Opens in a new windowHampton Inn Clarksdale
Quality Inn

Quality Inn

2.5 out of 5
818 South State Street Clarksdale MS
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $96 total per night from Feb 22 to Feb 23
$96 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A computer station, laundry facilities, and free newspapers are also on ...
it's was a good stay

Reviewed on Feb 13, 2026

Opens in a new windowQuality Inn
Americas Best Value Inn & Suites Clarksdale

Americas Best Value Inn & Suites Clarksdale

2.5 out of 5
350 South State Street Clarksdale MS
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $79 total per night from Feb 17 to Feb 18
$79 total
Feb 17 - Feb 18
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Yes

Reviewed on Nov 2, 2025

Opens in a new windowAmericas Best Value Inn & Suites Clarksdale
Don't see what you're looking for?
See all available properties in Lyon
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Lyon?
Take some of the worries out of traveling with little ones by staying in a family-friendly hotel in Lyon. From entertaining amenities to more services, these properties offer perks that'll make your trip run smoothly: You'll be well taken care of at Only a mile from historic downtown Clarksdale!. It comes with a swimming pool, a king bed and a knack for making families feel welcome. The Holy Moly Blues Central is another great choice. After a big day of exploring Lyon, come back home to your cozy room and amenities like a cafe and a picnic area.
Where can I find cheap hotels in Lyon?
At Travelocity you'll find really nice hotels in Lyon at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Lyon rather than in Lyon. We may find you even better rates, too.
How do I find the best Lyon hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Lyon then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Lyon?
The cheapest hotel in Lyon is $79. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Lyon?
There are 34 hotels in Lyon on Travelocity.
What are the best hotels in Lyon?
Lyon has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Lyon for you!
When is the best time to visit Lyon?
If you want the joy of a fun-filled trip in peak season, visit Lyon during June, September and October. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Lyon?
Based on historic data is usually the cheapest month to visit Lyon. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Lyon?
There are multiple hotels in Lyon that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Lyon. We have plenty of kid-friendly hotels in Lyon to choose from on Travelocity!
Why book a hotel in Lyon through Travelocity?
Because we have the top hotels in Lyon! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Lyon on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Lyon hotel reviews by fellow wanderers

Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

5 out of 5
Posted 6 days ago
Travelocity Verified Review
" Very easy check in. Rooms clean and comfortable with all néeded amenities. Located near downtown and accessible to shopping. Will stay here again if in the area. "
A verified traveler stayed at Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale
Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

Explore More Ways to Travel with Travelocity