Book Hotels in Lyon, MS

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Lyon hotels

Only a mile from historic downtown Clarksdale!

Only a mile from historic downtown Clarksdale!

Clarksdale MS
$213 nightly
The price is $227 total per night from May 25 to May 26
$227 total
May 25 - May 26
Total with taxes and fees
An outdoor pool is featured at this cottage, along with laundry facilities and barbecue grills.
"We enjoyed our stay immensely. Southern hospitality at its best!"

Reviewed on Apr 14, 2026

Opens in a new windowOnly a mile from historic downtown Clarksdale!
Travelers Hotel

Travelers Hotel

2.5 out of 5
212 3rd St Clarksdale MS
Fully refundableReserve now, pay when you stay
$150 nightly
The price is $164 total per night from May 24 to May 25
$164 total
May 24 - May 25
Total with taxes and fees
A bar/lounge and a fireplace in the lobby are featured at this hotel, along with free self parking. WiFi in public areas is free. Luggage storage is also ...
"Unique, characterful and comfortable. The included breakfast and coffee were great. The lounge was comfortable and attractive making the best from its commercial past. Really enjoyed my stay."

Reviewed on May 17, 2026

Opens in a new windowTravelers Hotel
Sunset Log Cabin

Sunset Log Cabin

Clarksdale MS
$173 nightly
The price is $186 total per night from May 24 to May 25
$186 total
May 24 - May 25
Total with taxes and fees
This cabin features barbecue grills.
"A true cabin experience but feels comfortable like home. It is close to the road but I was able to tune out the car noises. The view of sunset is amazing even in the winter time with the already harvested cotton field. All the necessary accessories are provided and very close to town. I’d suggest ..."

Reviewed on Dec 20, 2025

Opens in a new windowSunset Log Cabin
Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

Clarksdale MS
This vacation home features laundry facilities.
"The room was very clean and we enjoyed our stay."

Reviewed on May 23, 2026

Get rates
Opens in a new windowCasa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale
The Governors Mansion in Clarksdale Mississippi. A Step Back in Time

The Governors Mansion in Clarksdale Mississippi. A Step Back in Time

Clarksdale MS
An outdoor pool is featured at this villa, along with laundry facilities.
"The home was very clean and the description was accurate. The host was extremely responsive and kind.The home is in an excellent location for accessing downtown Clarksdale.The home could use a bit of TLC - painting, etc. However, this did not detract from the overall enjoyment and we would rent this ..."

Reviewed on May 22, 2026

Get rates
Opens in a new windowThe Governors Mansion in Clarksdale Mississippi. A Step Back in Time
Quality Inn Clarksdale

Quality Inn Clarksdale

2.5 out of 5
818 South State Street Clarksdale MS
Fully refundable
$88 nightly
The price is $96 total per night from Jun 17 to Jun 18
$96 total
Jun 17 - Jun 18
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A computer station, laundry facilities, and free newspapers are also on ...
"The breakfast was less than acceptable. The staff was wonderful. Everything else was excellent."

Reviewed on May 18, 2026

Opens in a new windowQuality Inn Clarksdale
Americas Best Value Inn & Suites Clarksdale

Americas Best Value Inn & Suites Clarksdale

2.5 out of 5
350 South State Street Clarksdale MS
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $87 total per night from May 24 to May 25
$87 total
May 24 - May 25
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"Needs to be updated."

Reviewed on May 13, 2026

Opens in a new windowAmericas Best Value Inn & Suites Clarksdale
Hampton Inn Clarksdale

Hampton Inn Clarksdale

2.5 out of 5
15000 New Africa Rd Clarksdale MS
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $157 total per night from May 31 to Jun 1
$157 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Opens in a new windowHampton Inn Clarksdale
Auberge Clarksdale Blues Hostel

Auberge Clarksdale Blues Hostel

2 out of 5
164 Delta Ave Clarksdale MS
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $134 total per night from May 24 to May 25
$134 total
May 24 - May 25
Total with taxes and fees
Free WiFi in public areas, a communal living room, and express check-out are available at this hostel. Dry cleaning, luggage storage, and locker space are also ...
Opens in a new windowAuberge Clarksdale Blues Hostel
Don't see what you're looking for?
See all available properties in Lyon
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Lyon?
Take some of the worries out of traveling with little ones by staying in a family-friendly hotel in Lyon. From entertaining amenities to more services, these properties offer perks that'll make your trip run smoothly: You'll be well taken care of at Only a mile from historic downtown Clarksdale!. It comes with a swimming pool, a king bed and a knack for making families feel welcome. The Holy Moly Blues Central is another great choice. After a big day of exploring Lyon, come back home to your cozy room and amenities like a cafe and a picnic area.
Where can I find cheap hotels in Lyon?
At Travelocity you'll find really nice hotels in Lyon at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Lyon rather than in Lyon. We may find you even better rates, too.
How do I find the best Lyon hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Lyon then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Lyon?
The cheapest hotel in Lyon is $87. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Lyon?
There are 34 hotels in Lyon on Travelocity.
What are the best hotels in Lyon?
Lyon has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Lyon for you!
When is the best time to visit Lyon?
If you want the joy of a fun-filled trip in peak season, visit Lyon during June, September and October. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Lyon?
Based on historic data is usually the cheapest month to visit Lyon. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Lyon?
There are multiple hotels in Lyon that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Lyon. We have plenty of kid-friendly hotels in Lyon to choose from on Travelocity!
Why book a hotel in Lyon through Travelocity?
Because we have the top hotels in Lyon! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Lyon on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Lyon hotel reviews by fellow wanderers

Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

5 out of 5
Posted 6 hours ago
Travelocity Verified Review
"The room was very clean and we enjoyed our stay."
A verified traveler stayed at Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale
Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

Explore More Ways to Travel with Travelocity