Explore top 2026 5 Star Hotels in Grand Center
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Top Grand Center 5 Star hotels

Four Seasons Hotel St Louis
999 North Second Street St. Louis MO
Fully refundableReserve now, pay when you stay
$415 nightly
The price is $485 total per night from Jan 20 to Jan 21
$485 total
Jan 20 - Jan 21
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Families will appreciate kid-friendly dining and in-room childcare. ...
9.4/10 Exceptional! (1,000 reviews)
Amazing
Reviewed on Jan 10, 2026

The Ritz-Carlton, St. Louis
100 Carondelet Plaza St. Louis MO
$499 nightly
The price is $583 total per night from Jan 18 to Jan 19
$583 total
Jan 18 - Jan 19
Total with taxes and fees
This smoke-free hotel's 2 restaurants, 3 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (556 reviews)
Very courteo
Reviewed on Jan 13, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Grand Center hotel reviews by fellow wanderers

Clayton Plaza Hotel & Extended Stay
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Nice place — this hotel is a little older but clean, the rooms are spacious and nice— the showers are amazing and the breakfast buffet is great — could use better and stronger coffee."
A verified traveler stayed at Clayton Plaza Hotel & Extended Stay
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