Explore top 2026 4 Star Hotels in Affton

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Top Affton 4 Star hotels

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $162 total per night from Jun 12 to Jun 13
$162 total
Jun 12 - Jun 13
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.6/10 Excellent! (4,080 reviews)
"The property was very clean. The staff was helpful. I liked after we watched the baseball game, walking back to the hotel and sitting at the bar for a drink. That was very nice. A good night Sleep we’re very pleased."

Reviewed on Jun 5, 2026

Opens in a new windowHyatt Regency St. Louis at The Arch
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $179 total per night from Jul 5 to Jul 6
$179 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.8/10 Excellent! (723 reviews)
"Dinning and pool areas were enjoyable."

Reviewed on Jun 2, 2026

Opens in a new windowLe Méridien St. Louis Clayton
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $189 total per night from Jun 21 to Jun 22
$189 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (1,204 reviews)
"Went to St Louis to watch a couple of Cardinals Games. And excellent location to say the least. Staff was fantastic and very helpful. Also had room service for breakfast. Food was very good and an excellent value as well. Well return soon!"

Reviewed on Jun 4, 2026

Opens in a new windowLive by Loews - St.Louis
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $158 total per night from Jun 28 to Jun 29
$158 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
Opens in a new windowRenaissance St. Louis Airport Hotel
Marriott St. Louis Grand

Marriott St. Louis Grand

4 out of 5
800 Washington Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $181 total per night from Jun 11 to Jun 12
$181 total
Jun 11 - Jun 12
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.2/10 Very Good! (1,014 reviews)
"My sister and nephew loved the bar"

Reviewed on Jun 4, 2026

Opens in a new windowMarriott St. Louis Grand
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$165 nightly
The price is $193 total per night from Jun 11 to Jun 12
$193 total
Jun 11 - Jun 12
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,883 reviews)
"I loved this hotel! It truly felt like a nice getaway and was absolutely beautiful! The Staff was very nice and professional. We ate breakfast where the coffee shop was and the breakfast burrito was so good! We will be back!"

Reviewed on Jun 5, 2026

Opens in a new window21C Museum Hotel St Louis
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
$209 nightly
The price is $246 total per night from Jun 14 to Jun 15
$246 total
Jun 14 - Jun 15
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9/10 Wonderful! (1,006 reviews)
"Very nice all around, staff was very friendly and helpful, the rooms was clean, the hotel was beautiful"

Reviewed on Jun 1, 2026

Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $113 total per night from Jul 1 to Jul 2
$113 total
Jul 1 - Jul 2
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
Opens in a new windowRiver City Casino & Hotel
Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark

4 out of 5
1 S Broadway St. Louis MO
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $204 total per night from Jun 11 to Jun 12
$204 total
Jun 11 - Jun 12
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an indoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
7.6/10 Good! (1,156 reviews)
"The bathrooms are super tiny and the water pressure and hot water was NOT good!"

Reviewed on Jun 4, 2026

Opens in a new windowHilton St. Louis at the Ballpark
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $136 total per night from Jul 5 to Jul 6
$136 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.8/10 Excellent! (1,289 reviews)
"I recently stayed here to celebrate my wedding. The hotel itself is nice. I enjoyed the valet service, but unfortunately, Maintenance broke some of our personalized celebratory items and discarded them without a word. The hotel staff was kind of dismissive of this. I did enjoy the chocolate covered ..."

Reviewed on Jun 4, 2026

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
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4 Star Hotels Affton

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Affton 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Affton will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Affton, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Affton hotel reviews by fellow wanderers

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