Book Hotels in Sedgewickville, MO
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Sedgewickville hotels
Secluded 5-Bedroom Lodge with Private Lake – Perfect for Large Groups!
Perryville MO
This lodge featured laundry facilities and barbecue grills.
"This property is amazing and the hosts are fantastic!! We stay at a lot of rentals and this was by far the cleanest, best stocked home we have ever rented. There was such thought put into providing guests with every single thing they may need - and there was no skimping!! Plus, we received an over ..."
Reviewed on Aug 25, 2026
Silo Farm Haus- located in the heart of wine country!
Ste. Genevieve MO
$312 nightly
The price is $351 total per night from Sep 30 to Oct 1
$351 total
Sep 30 - Oct 1
Total with taxes and fees
This vacation home features laundry facilities.
"We were quite impressed with what has been done with the silo! Everything was clean and comfortable upon our arrival. The area was nice and quiet – just what we were looking for away from the city. Sunsets and star gazing were amazing. We would definitely love to come back to the area in the fall ..."
Reviewed on Sep 6, 2026
Drury Inn & Suites Jackson MO
225 Drury Lane Jackson MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $89 total per night from Oct 11 to Oct 12
$89 total
Oct 11 - Oct 12
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"We had such a wonderful stay at this hotel! The entire property was very clean and well cared for. You could really tell that they take pride in keeping the rooms and common areas in great condition. The staff were incredibly friendly, welcoming, and personable, which made us feel right at home. ..."
Reviewed on Sep 26, 2026
Holiday Inn Express & Suites Perryville by IHG
2020 Jefferson St Perryville MO
Fully refundable
$105 nightly
The price is $120 total per night from Oct 4 to Oct 5
$120 total
Oct 4 - Oct 5
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"Check in and check out for 25 rooms was a breeze. Hotel room cards were ready as soon as we approached the hotel counter."
Reviewed on Sep 27, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $91 total per night from Oct 1 to Oct 2
$91 total
Oct 1 - Oct 2
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
"Clean rooms. Nice breakfast. Very nice staff."
Reviewed on Sep 28, 2026
Super 8 by Wyndham Perryville
1119 Vincent Dr Perryville MO
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $82 total per night from Oct 6 to Oct 7
$82 total
Oct 6 - Oct 7
Total with taxes and fees
This motel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"The staff is accommodating and room clean… perfect for my stay rolling through the area."
Reviewed on Sep 28, 2026
Madison Inn Lodge
730 Plaza Drive Fredericktown MO
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $96 total per night from Sep 30 to Oct 1
$96 total
Sep 30 - Oct 1
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like continental breakfast and ...
"Nothing"
Reviewed on Sep 27, 2026
Quality Inn Cape Girardeau North
2011 North Kingshighway Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $68 total per night from Oct 11 to Oct 12
$68 total
Oct 11 - Oct 12
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...
"Horrible smell in lobby. Room towels had blood stains. Bath tub dirty, remote for tv inoperative. Would not recommend this hotel for a dog!! Nasty"
Reviewed on Sep 27, 2026
Tru By Hilton Cape Girardeau
2520 Veterans Memorial Dr Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $102 total per night from Oct 5 to Oct 6
$102 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features an indoor pool and a gym. Guests will appreciate freebies like daily breakfast and free self parking. Staff at the 24-hour front desk can ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Sedgewickville hotel reviews by fellow wanderers
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
5 out of 5
Posted 18 hours ago
Travelocity Verified Review
"Clean rooms. Nice breakfast. Very nice staff."
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
