Santiago Vacation Packages 2026 from $371

Santiago flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Mahogany Suites

$371

per person

Apr 23 - Apr 26

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

A golf course and an outdoor pool are featured at this hotel. A garden is also provided.

Casa Lefevre By Wynwood House

Casco Viejo

$940

per person

May 13 - May 20

found 19 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

This apartment features a virtual front desk.

Central Hotel Panama Casco Viejo

Casco Viejo

$750

per person

Apr 11 - Apr 13

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Playa Caracol

$1,357

per person

Apr 24 - May 1

found 21 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

A private beach, 2 restaurants, and 3 outdoor pools are all featured at this smoke-free villa. Relax with beach umbrellas and enjoy a refreshing drink at one of the 2 beach bars. Enjoy the 2 outdoor tennis courts and get free self parking.

Casa Mallet by Wynwood House

Casco Viejo

$1,248

per person

May 13 - May 20

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

Free WiFi in public areas is available at this apartment. Take advantage of the self parking.

Top Santiago hotels deals

Hotel Gran David

Vía Interamericana Santiago Veraguas

Free Cancellation

Reserve now, pay when you stay

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This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference space. Enjoy the 24-hour gym and free perks like cooked-to-order breakfast and free self parking.

Minutes from downtown Santiago, Chicho Fábrega hospital and Universidad Latina.

Panama Panamá

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This vacation home includes a garden and laundry facilities.

HOTEL PLAZA COROTÚ

Carr. Panamericana Santiago Provincia de Veraguas

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Free WiFi in public areas is provided and the front desk is staffed around-the-clock. Laundry facilities are provided for your convenience.

The Spring Loft | Santiago

Santiago Provincia de Veraguas

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A garden is available at this apartment.

Hostal Travelers

Santiago de Veraguas Santiago Veraguas

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This hostal doesn't skimp on freebies - guests receive free WiFi and free self parking. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including food and water bowls. A terrace, a garden, and a snack bar/deli are also on offer.

Hotel Mykonos Panama

Panamerican Highway Nuevo Santiago Veraguas

Free Cancellation

Reserve now, pay when you stay

$76 nightly

$85 total

Mar 17 - Mar 18

Total with taxes and fees

This smoke-free hotel features a full-service spa, 3 outdoor pools, and a restaurant. There's fun for all ages with a children's pool and a playground, and families will appreciate the onsite laundry facilities. Enjoy the gym and free perks like cooked-to-order breakfast and valet parking.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Escuela Normal Juan Demostenes Arosemena

5/5(2 reviews)

Explore the campus of Escuela Normal Juan Demostenes Arosemena, during your trip to Santiago. Stroll along the lakeside or visit the cathedral while you're in the area.

Catedral of Santiago Apostol

Find out about the history of Santiago when you take a trip to Catedral of Santiago Apostol. Amble around the area's lakeside or visit its cathedral.

Omar Torrijos Herrera Stadium

4/5(1 review)

Catch an event at Omar Torrijos Herrera Stadium during your trip to Santiago. Amble around the area's lakeside or visit its cathedral.

Frequently asked questions

How much are vacation packages to Santiago?

Packages, which provide both flights and hotels in Santiago, start from $371. Turn your travel fantasies into reality and book your trip with Travelocity today.

Where can I get the best vacation package deals for Santiago?

You'll come across a terrific selection of Santiago package deals on Travelocity. With as many as 400 airlines and 1,000,000 properties worldwide, crafting the ultimate escape will be a piece of cake.

Why should I purchase my Santiago vacation package with Travelocity?

Travel is all about making cherished new memories and leaving all your troubles behind — which is why we provide you with a team of experts on hand around-the-clock should you need them. On top of that, our Price Match Guarantee ensures you'll always get the best price available on our terrific range of destinations. So what are you waiting for? There's no time like the present to lock in that vacation you've always wanted.

Can I save on my Santiago car rental if I book it with a hotel or flight?

With a Santiago vacation package, you can combine your hotel, car and flight bookings and save loads. If you want to see the best of this fabulous area, why not start with Miraflores Locks? This popular sight is 110 mi from Santiago. With a rental car, you'll be there before you know it.

What is there to do in Santiago?

While getting off the beaten track can be rewarding, you really shouldn't miss the big-name sights that make a place famous. Catedral of Santiago Apostol and Omar Torrijos Herrera Stadium are a couple of them in Santiago.

Where should I stay when visiting Santiago?

The Hotel Gran David is popular with many travelers. Book now before it's too late.