Book Hotels in Santee, NE

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Top Santee hotels

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Crofton NE
$808 nightly
The price is $893 total per night from May 7 to May 8
$893 total
May 7 - May 8
Total with taxes and fees
This vacation home includes a garden and laundry facilities.
Our family had a wonderful time staying in this lovely house. It is so full of light and spacious. We were able to put the littles to bed early on a different floor while the adults played loud games. The ping pong table was great entertainment to keep kids off their phones too! We would stay here ...

Reviewed on Mar 8, 2026

Opens in a new windowModern Lewis and Clark lake home with lake views and 3 min drive to the beach!
Haven by the Lake

Haven by the Lake

Yankton SD
This vacation home features a garden, laundry facilities, and barbecue grills.
Property as as listed. Only issue was with a kitchen smoke detector, and it was resolved.

Reviewed on Apr 6, 2026

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Opens in a new windowHaven by the Lake
Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake

Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake

Crofton NE
Stay at this cabin in Crofton. Enjoy air conditioning. Popular attractions Deep Water Recreation Area and Lewis and Clark Lake State Recreation Area are located ...
Very nice cabin, very great location, we had a good time there, everyone there very friendly, planning on conning back again

Reviewed on Oct 26, 2025

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Opens in a new windowCozy cabin near Lewis and Clark Lake and CJ’s at the Lake
The Lake House - Lakeview with 6 bedrooms - Yankton, SD

The Lake House - Lakeview with 6 bedrooms - Yankton, SD

Yankton SD
This vacation home features a garden, laundry facilities, and barbecue grills.
Great stay like always

Reviewed on Oct 19, 2025

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Opens in a new windowThe Lake House - Lakeview with 6 bedrooms - Yankton, SD
Leather&Spruce - Luxury Lake area fun funky home with amenities. Great for 2-18!

Leather&Spruce - Luxury Lake area fun funky home with amenities. Great for 2-18!

Yankton SD
$833 nightly
The price is $875 total per night from Apr 22 to Apr 23
$875 total
Apr 22 - Apr 23
Total with taxes and fees
A gym is featured at this vacation home, along with limo/town car service and a garden. There's fun for all ages with a playground and an arcade/game room, and ...
Excellent set up, clean and furnished beautifully.

Reviewed on Nov 9, 2025

Opens in a new windowLeather&Spruce - Luxury Lake area fun funky home with amenities. Great for 2-18!
ThePinecone - luxury vacation rental awesome deck with view & amenities for 2-18

ThePinecone - luxury vacation rental awesome deck with view & amenities for 2-18

Yankton SD
$833 nightly
The price is $875 total per night from Apr 22 to Apr 23
$875 total
Apr 22 - Apr 23
Total with taxes and fees
A hot tub is featured at this vacation home, along with limo/town car service and a garden. Families will appreciate the playground and onsite laundry facilities. ...
The space was very nice for visiting, the kitchen was well equipped except can opener should be trashed and new one gotten. Home was clean and very bright - so many windows. Beds/sleeping was not what was posted on VRBO. Not cleaning the sidewalks and driveway in a timely manner after the snow and ...

Reviewed on Dec 3, 2025

Opens in a new windowThePinecone - luxury vacation rental awesome deck with view & amenities for 2-18
Spacious Lakeview Cabin Minutes from Private Beach

Spacious Lakeview Cabin Minutes from Private Beach

Crofton NE
This cabin featured laundry facilities and barbecue grills.
Great place to stay with a large group. Awesome view of the lake.

Reviewed on Mar 5, 2026

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Opens in a new windowSpacious Lakeview Cabin Minutes from Private Beach
Lewis and Clark Resort

Lewis and Clark Resort

2.5 out of 5
43496 Shore Drive Yankton SD
$89 nightly
The price is $94 total per night from Apr 22 to Apr 23
$94 total
Apr 22 - Apr 23
Total with taxes and fees
A marina and a restaurant are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference ...
Very easy parking good if you have a U-Haul and family beautiful lake in the back

Reviewed on Apr 11, 2026

Opens in a new windowLewis and Clark Resort
Gavins Point Lakehouse

Gavins Point Lakehouse

Yankton SD
This vacation home includes a garden and laundry facilities.
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Opens in a new windowGavins Point Lakehouse
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Santee?
From cool amenities to extra space, kid-friendly hotels come with features that can help transform a routine family vacation into a sensational one. These Santee options make vacationing with your youngsters child's play: The whole team will enjoy their time at Private updated hunting lodge/farmhouse. Pet-friendly facilities and a barbecue grill are just a few of the things that help make this property a favorite. Bear Historic Home is another excellent choice. After an exciting day of exploring, come home to your cozy room and amenities like a king bed and animal viewing activities.
Where can I find cheap hotels in Santee?
At Travelocity you'll find really nice hotels in Santee at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Santee rather than in Santee. We may find you even better rates, too.
How do I find the best Santee hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Santee then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Santee?
The cheapest hotel in Santee is $94. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Santee?
There are 59 hotels in Santee on Travelocity.
What are the best hotels in Santee?
Santee has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Santee for you!
When is the best time to visit Santee?
If you want the joy of a fun-filled trip in peak season, visit Santee during May, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as November, December and January.
When is the cheapest time to stay in Santee?
Based on historic data is usually the cheapest month to visit Santee. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Santee?
There are multiple hotels in Santee that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Santee. We have plenty of kid-friendly hotels in Santee to choose from on Travelocity!
Why book a hotel in Santee through Travelocity?
Because we have the top hotels in Santee! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Santee on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Santee hotel reviews by fellow wanderers

Lewis and Clark Resort

Lewis and Clark Resort

5 out of 5
Posted 10 days ago
Travelocity Verified Review
"Very easy parking good if you have a U-Haul and family beautiful lake in the back"
A verified traveler stayed at Lewis and Clark Resort
Lewis and Clark Resort

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