Santa Isabel Vacation Packages 2026 from $722

Santa Isabel flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Casa Lefevre By Wynwood House

Casco Viejo

$722

per person

Aug 9 - Aug 13

found 1 day ago

Roundtrip non-stop flight included

Georgetown (GEO) to Panama City (PTY)

This apartment features a virtual front desk.

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,011

per person

Aug 11 - Aug 16

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Central Hotel Bocas del Toro

Save 100% on your flight

$1,135

per person

Sep 5 - Sep 9

found 1 day ago

Roundtrip flight included

New York (NYC) to Panama City (PTY)

This smoke-free hotel features a full-service spa, a marina, and a restaurant. Enjoy the outdoor pool and free perks like cooked-to-order breakfast and WiFi in public areas. You'll appreciate the gym, bar/lounge, and laundry facilities.

Megapolis Hotel Panamá

San Francisco

$910

per person

Aug 11 - Aug 16

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free valet parking. Relax with a drink at one of the 3 bars/lounges and enjoy free perks like buffet breakfast and free self parking.

Riande Aeropuerto Hotel & Casino

$808

per person

Aug 11 - Aug 16

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

This smoke-free resort features a casino, 2 indoor tennis courts, and a restaurant. Bring the family and enjoy the children's pool, playground, and kid-friendly dining. Enjoy the outdoor pool and free perks like full breakfast and valet parking.

Top Santa Isabel hotels deals

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir Narganá Guna Yala

Free Cancellation

Reserve now, pay when you stay

$1,974 nightly

$2,178 total

Jul 6 - Jul 7

Total with taxes and fees

A restaurant and a bar/lounge are featured at this cruise ship. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A coffee shop and a snack bar/deli are also provided.

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala

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This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.

Private wood Cabins on San Blas island - private bathroom

Wailidup Island Narganá Guna Yala

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A marina and a restaurant are featured at this smoke-free hotel. Enjoy the outdoor pool and free local cuisine breakfast each morning. You'll appreciate the area shuttle, terrace, and snack bar/deli.

Caribbean Haven Of Nature 'Preci Beach'

Nombre de Dios Colon

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This vacation home features an outdoor pool and a hot tub. A garden, laundry facilities, and barbecue grills are also on offer.

Cabins on paradise San Blas island

9.587566, -78.879820 Narganá San Blas

Free Cancellation

Reserve now, pay when you stay

$269 nightly

$296 total

Jun 30 - Jul 1

Total with taxes and fees

A restaurant and a snack bar/deli are featured at this hotel. Enjoy the free local cuisine breakfast each morning. Take advantage of the area shuttle.

Caribbean getaway: beach cottage just on the sand

Palenque Provincia de Colón

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This cottage features a garden, laundry facilities, and barbecue grills.

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See all available properties in Santa Isabel

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much are vacation packages to Santa Isabel?

You might be pleasantly surprised — you can recharge your batteries in Santa Isabel for a mere $722. At Travelocity, we save you time and money with our amazing vacation packages. With experiences, hotels and flights all in one place, why put it off?

Where can I get the best vacation package deals for Santa Isabel?

Travelocity is here to help you lock in an unbeatable Santa Isabel package deal. With 400 airlines and 1,000,000 properties worldwide, we're sure you'll be able to craft the perfect itinerary.

Why should I book my Santa Isabel vacation package via Travelocity?

With our Price Match Guarantee, we'll match any lower price you find. Add to that our 24/7 customer support and high-quality service and the vacation of your dreams is closer than ever before.

Can I save on my Santa Isabel car rental if I bundle it with a hotel or flight?

You certainly can — bundle your car, flight and hotel into a Santa Isabel vacation package and you'll save plenty. With so many things to do in and around Santa Isabel, that rental vehicle will make exploring a joy. Once you've settled into the driver's seat, get out on the wide open road and head to Miraflores Locks, a renowned attraction roughly 45 mi from Santa Isabel.

Which airport is best for Santa Isabel?

There are two choices for flying to Santa Isabel, starting with Tocumen Intl. Airport (PTY). It's about 35 mi from the center of the city, while Marcos A. Gelabert Intl. Airport (PAC) is 45 mi away from central Santa Isabel.