Santa Isabel Vacation Packages 2026 from $953

Santa Isabel flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Decapolis Hotel Panama City

San Francisco

$953

per person

Nov 25 - Nov 29

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, and free valet parking. Enjoy the outdoor pool and free buffet breakfast each morning.

Las Clementinas

Casco Viejo

$1,524

per person

Jan 2 - Jan 9

found 1 day ago

Roundtrip flight included

New York (NYC) to Panama City (PTY)

A restaurant and a bar/lounge are featured at this aparthotel. WiFi in public areas is free. Self parking, a terrace, and a garden are also offered.

American Trade Hotel

Casco Viejo

$2,123

per person

Jan 2 - Jan 9

found 1 day ago

Roundtrip flight included

New York (NYC) to Panama City (PTY)

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, and airport shuttle. There's a gym on site, and laundry facilities and concierge services are also offered.

Surfside Beachfront Suites by Playa Caracol Resorts

$1,681

per person

Dec 21 - Dec 27

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Panama City (PTY)

This smoke-free apartment features 2 outdoor pools, a restaurant, and a bar/lounge. Relax with a drink at the poolside bar and enjoy perks like free self parking. A coffee shop and a snack bar/deli are also provided.

Casa Mallet by Wynwood House

Casco Viejo

$1,253

per person

Dec 4 - Dec 8

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

Free WiFi in public areas is available at this apartment. Take advantage of the self parking.

Top Santa Isabel hotels deals

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala

$188 nightly

$207 total

Oct 31 - Nov 1

Total with taxes and fees

This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.

Breakfast included

Restaurant

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir Narganá Guna Yala

Free Cancellation

Reserve now, pay when you stay

Get rates

A restaurant and a bar/lounge are featured at this cruise ship. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A coffee shop and a snack bar/deli are also provided.

Breakfast included

Free WiFi

Caribbean Haven Of Nature 'Preci Beach'

Nombre de Dios Colon

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This vacation home features an outdoor pool and a hot tub. A garden, laundry facilities, and barbecue grills are also on offer.

Pool

Hot Tub

Private wood Cabins on San Blas island - private bathroom

Wailidup Island Narganá Guna Yala

$131 nightly

$144 total

Nov 4 - Nov 5

Total with taxes and fees

A marina and a restaurant are featured at this smoke-free hotel. Enjoy the outdoor pool and free local cuisine breakfast each morning. You'll appreciate the area shuttle, terrace, and snack bar/deli.

Pool

Breakfast included

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Santa Isabel Colon

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This villa features limo/town car service, a garden, and laundry facilities. Barbecue grills are provided for your convenience.

Kitchen

Washer

Caribbean getaway: beach cottage just on the sand

Palenque Provincia de Colón

$317 nightly

$317 total

Oct 20 - Oct 21

Total with taxes and fees

This cottage features a garden, laundry facilities, and barbecue grills.

Kitchen

Washer

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much are vacation packages to Santa Isabel?

You might be pleasantly surprised — you can recharge your batteries in Santa Isabel for a mere $953. At Travelocity, we save you time and money with our amazing vacation packages. With experiences, hotels and flights all in one place, why put it off?

Where can I get the best vacation package deals for Santa Isabel?

Travelocity is here to help you lock in an unbeatable Santa Isabel package deal. With 400 airlines and 1,000,000 properties worldwide, we're sure you'll be able to craft the perfect itinerary.

Why should I book my Santa Isabel vacation package via Travelocity?

With our Price Match Guarantee, we'll match any lower price you find. Add to that our 24/7 customer support and high-quality service and the vacation of your dreams is closer than ever before.

Can I save on my Santa Isabel car rental if I bundle it with a hotel or flight?

You certainly can — bundle your car, flight and hotel into a Santa Isabel vacation package and you'll save plenty. With so many things to do in and around Santa Isabel, that rental vehicle will make exploring a joy. Once you've settled into the driver's seat, get out on the wide open road and head to Miraflores Locks, a renowned attraction roughly 45 mi from Santa Isabel.

Which airport is best for Santa Isabel?

There are two choices for flying to Santa Isabel, starting with Tocumen Intl. Airport (PTY). It's about 35 mi from the center of the city, while Marcos A. Gelabert Intl. Airport (PAC) is 45 mi away from central Santa Isabel.