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Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Tocumen Airport
Price was $1,669, price is now $1,069 per person
$1,069
per person
Nov 11 - Nov 18
found 24 hours ago
Roundtrip non-stop flight included
Cleveland (CLE) to Panama City (PTY)
This smoke-free resort features a casino, 2 indoor tennis courts, and a restaurant. Bring the family and enjoy the children's pool, playground, and kid-friendly dining. Enjoy the outdoor pool and free perks like full breakfast and valet parking.
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $3,493, price is now $1,660 per person
$1,660
per person
Nov 11 - Nov 18
found 24 hours ago
Roundtrip non-stop flight included
Cleveland (CLE) to Panama City (PTY)
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $2,899, price is now $1,449 per person
$1,449
per person
Dec 15 - Dec 20
found 1 day ago
Roundtrip non-stop flight included
Dallas (DFW) to Panama City (PTY)
This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free valet parking. Relax with a drink at one of the 3 bars/lounges and enjoy free perks like buffet breakfast and free self parking.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,630, price is now $1,168 per person
$1,168
per person
Nov 11 - Nov 18
found 24 hours ago
Roundtrip non-stop flight included
Cleveland (CLE) to Panama City (PTY)
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Relax with a drink at the bar/lounge and enjoy the free buffet breakfast each morning.
Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Bella Vista
Price was $1,828, price is now $1,317 per person
$1,317
per person
Nov 11 - Nov 18
found 24 hours ago
Roundtrip non-stop flight included
Cleveland (CLE) to Panama City (PTY)
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and airport shuttle. Relax with a drink at one of the 2 bars/lounges and enjoy perks like free valet parking.

Top Santa Isabel hotels deals

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
$188 nightly
The price is $207 total per night
$207 total
Oct 6 - Oct 7
Total with taxes and fees
This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.
Breakfast included
Restaurant
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Free Cancellation
Reserve now, pay when you stay
$1,943 nightly
The price is $2,148 total per night
$2,148 total
Nov 4 - Nov 5
Total with taxes and fees
A restaurant and a bar/lounge are featured at this cruise ship. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A coffee shop and a snack bar/deli are also provided.
Breakfast included
Free WiFi
Caribbean Haven Of Nature 'Preci Beach'

Caribbean Haven Of Nature 'Preci Beach'

Nombre de Dios Colon
Get rates
This vacation home features an outdoor pool and a hot tub. A garden, laundry facilities, and barbecue grills are also on offer.
Pool
Hot Tub
Private wood Cabins on San Blas island - private bathroom

Private wood Cabins on San Blas island - private bathroom

2 out of 5
Wailidup Island Narganá Guna Yala
$131 nightly
The price is $144 total per night
$144 total
Nov 1 - Nov 2
Total with taxes and fees
A marina and a restaurant are featured at this smoke-free hotel. Enjoy the outdoor pool and free local cuisine breakfast each morning. You'll appreciate the area shuttle, terrace, and snack bar/deli.
Pool
Breakfast included
BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Santa Isabel Colon
Get rates
This villa features limo/town car service, a garden, and laundry facilities. Barbecue grills are provided for your convenience.
Kitchen
Washer
Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand

Palenque Provincia de Colón
$316 nightly
The price is $316 total per night
$316 total
Oct 5 - Oct 6
Total with taxes and fees
This cottage features a garden, laundry facilities, and barbecue grills.
Kitchen
Washer
Don't see what you're looking for?
See all available properties in Santa Isabel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much are vacation packages to Santa Isabel?
You might be pleasantly surprised — you can recharge your batteries in Santa Isabel for a mere $1,069. At Travelocity, we save you time and money with our amazing vacation packages. With experiences, hotels and flights all in one place, why put it off?
Where can I get the best vacation package deals for Santa Isabel?
Travelocity is here to help you lock in an unbeatable Santa Isabel package deal. With 400 airlines and 1,000,000 properties worldwide, we're sure you'll be able to craft the perfect itinerary.
Why should I book my Santa Isabel vacation package via Travelocity?
With our Price Match Guarantee, we'll match any lower price you find. Add to that our 24/7 customer support and high-quality service and the vacation of your dreams is closer than ever before.
Can I save on my Santa Isabel car rental if I bundle it with a hotel or flight?
You certainly can — bundle your car, flight and hotel into a Santa Isabel vacation package and you'll save plenty. With so many things to do in and around Santa Isabel, that rental vehicle will make exploring a joy. Once you've settled into the driver's seat, get out on the wide open road and head to Miraflores Locks, a renowned attraction roughly 45 mi from Santa Isabel.
Which airport is best for Santa Isabel?
There are two choices for flying to Santa Isabel, starting with Tocumen Intl. Airport (PTY). It's about 35 mi from the center of the city, while Marcos A. Gelabert Intl. Airport (PAC) is 45 mi away from central Santa Isabel.

Photos of local treasures

Browse Santa Isabel vacation photos for more inspiration

A tropical island with a beach, clear turquoise waters, and lush greenery.
A boat on a turquoise sea with lush green islands in the background.
A tropical island with turquoise waters, a sandy beach, and lush greenery.