Santa Isabel Vacation Packages 2026 from $724

Santa Isabel flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Villa Botero By Casa Mojito B&B

$724

per person

May 3 - May 9

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to Panama City (PTY)

This bed & breakfast features an outdoor pool and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. An area shuttle, a casino shuttle, and laundry facilities are also offered.

Mahogany Suites

$839

per person

Jun 1 - Jun 7

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

A golf course and an outdoor pool are featured at this hotel. A garden is also provided.

Hotel Plaza Herrera

Casco Viejo

Save 100% on your flight

$1,246

per person

May 19 - May 25

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

An attached winery and a restaurant are featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and airport shuttle. Valet parking, a coffee shop, and a snack bar/deli are also offered.

Megapolis Hotel Panamá

San Francisco

$1,242

per person

Jun 16 - Jun 23

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free valet parking. Relax with a drink at one of the 3 bars/lounges and enjoy free perks like buffet breakfast and free self parking.

Hotel Riu Plaza Panama

Bella Vista

$1,051

per person

Jun 16 - Jun 23

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Relax with a drink at the bar/lounge and enjoy the free buffet breakfast each morning.

Top Santa Isabel hotels deals

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala

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This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.

Breakfast included

Restaurant

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir Narganá Guna Yala

Free Cancellation

Reserve now, pay when you stay

$1,953 nightly

$2,158 total

Apr 9 - Apr 10

Total with taxes and fees

A restaurant and a bar/lounge are featured at this property. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A coffee shop and a snack bar/deli are also provided.

Breakfast included

Free WiFi

Trips Guna Yala

Urgandi, Mamardub Narganá Guna Yala

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An outdoor pool is featured at this bed & breakfast, along with a virtual front desk. Enjoy the free continental breakfast each morning.

Pool

Breakfast included

Paradise Over the Water Cabins in San Blas

G4V2 48 Narganá Guna Yala

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A restaurant is available at this cabin. Enjoy the free continental breakfast each morning.

Breakfast included

Restaurant

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Santa Isabel Colon

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This villa features limo/town car service, a garden, and laundry facilities. Barbecue grills are provided for your convenience.

Kitchen

Washer

Caribbean Haven Of Nature 'Preci Beach'

Nombre de Dios Colon

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This vacation home features an outdoor pool and a hot tub. A garden, laundry facilities, and barbecue grills are also on offer.

Pool

Hot Tub

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much are vacation packages to Santa Isabel?

You might be pleasantly surprised — you can recharge your batteries in Santa Isabel for a mere $724. At Travelocity, we save you time and money with our amazing vacation packages. With experiences, hotels and flights all in one place, why put it off?

Where can I get the best vacation package deals for Santa Isabel?

Travelocity is here to help you lock in an unbeatable Santa Isabel package deal. With 400 airlines and 1,000,000 properties worldwide, we're sure you'll be able to craft the perfect itinerary.

Why should I book my Santa Isabel vacation package via Travelocity?

With our Price Match Guarantee, we'll match any lower price you find. Add to that our 24/7 customer support and high-quality service and the vacation of your dreams is closer than ever before.

Can I save on my Santa Isabel car rental if I bundle it with a hotel or flight?

You certainly can — bundle your car, flight and hotel into a Santa Isabel vacation package and you'll save plenty. With so many things to do in and around Santa Isabel, that rental vehicle will make exploring a joy. Once you've settled into the driver's seat, get out on the wide open road and head to Miraflores Locks, a renowned attraction roughly 45 mi from Santa Isabel.

Which airport is best for Santa Isabel?

There are two choices for flying to Santa Isabel, starting with Tocumen Intl. Airport (PTY). It's about 35 mi from the center of the city, while Marcos A. Gelabert Intl. Airport (PAC) is 45 mi away from central Santa Isabel.