Santa Isabel Vacation Packages 2026 from $475

Santa Isabel flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Mahogany Suites

$475

per person

Apr 25 - Apr 30

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

A golf course and an outdoor pool are featured at this hotel.

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$950

per person

Apr 25 - Apr 30

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Villa Botero By Casa Mojito B&B

Save 100% on your flight

$904

per person

Mar 25 - Apr 1

found 10 hours ago

Roundtrip non-stop flight included

Dallas (DFW) to Panama City (PTY)

This bed & breakfast features an outdoor pool and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. An area shuttle, a casino shuttle, and laundry facilities are also offered.

Hotel Riu Plaza Panama

Bella Vista

$614

per person

Apr 25 - Apr 30

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Relax with a drink at the bar/lounge and enjoy the free buffet breakfast each morning.

Megapolis Hotel Panamá

San Francisco

$806

per person

May 7 - May 11

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free valet parking. Relax with a drink at one of the 3 bars/lounges and enjoy free perks like buffet breakfast and free self parking.

Top Santa Isabel hotels deals

Caribbean getaway: beach cottage just on the sand

Palenque Provincia de Colón

$323 nightly

$323 total

Feb 22 - Feb 23

Total with taxes and fees

This cottage features a garden, laundry facilities, and barbecue grills.

Kitchen

Washer

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir Narganá Guna Yala

Free Cancellation

Reserve now, pay when you stay

$1,875 nightly

$2,072 total

Feb 24 - Feb 25

Total with taxes and fees

A restaurant and a bar/lounge are featured at this property. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A coffee shop and a snack bar/deli are also provided.

Breakfast included

Free WiFi

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala

$188 nightly

$207 total

Mar 3 - Mar 4

Total with taxes and fees

This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.

Breakfast included

Restaurant

Trips Guna Yala

Urgandi, Mamardub Narganá Guna Yala

Free Cancellation

Reserve now, pay when you stay

$214 nightly

$236 total

Feb 23 - Feb 24

Total with taxes and fees

An outdoor pool is featured at this bed & breakfast, along with a virtual front desk. Enjoy the free continental breakfast each morning.

Pool

Breakfast included

Paradise Over the Water Cabins in San Blas

G4V2 48 Narganá Guna Yala

Get rates

A restaurant is available at this cabin. Enjoy the free continental breakfast each morning.

Breakfast included

Restaurant

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Santa Isabel Colon

Get rates

This villa features limo/town car service, a garden, and laundry facilities. Barbecue grills are provided for your convenience.

Kitchen

Washer

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much are vacation packages to Santa Isabel?

You might be pleasantly surprised — you can recharge your batteries in Santa Isabel for a mere $475. At Travelocity, we save you time and money with our amazing vacation packages. With experiences, hotels and flights all in one place, why put it off?

Where can I get the best vacation package deals for Santa Isabel?

Travelocity is here to help you lock in an unbeatable Santa Isabel package deal. With 400 airlines and 1,000,000 properties worldwide, we're sure you'll be able to craft the perfect itinerary.

Why should I book my Santa Isabel vacation package via Travelocity?

With our Price Match Guarantee, we'll match any lower price you find. Add to that our 24/7 customer support and high-quality service and the vacation of your dreams is closer than ever before.

Can I save on my Santa Isabel car rental if I bundle it with a hotel or flight?

You certainly can — bundle your car, flight and hotel into a Santa Isabel vacation package and you'll save plenty. With so many things to do in and around Santa Isabel, that rental vehicle will make exploring a joy. Once you've settled into the driver's seat, get out on the wide open road and head to Miraflores Locks, a renowned attraction roughly 45 mi from Santa Isabel.

Which airport is best for Santa Isabel?

There are two choices for flying to Santa Isabel, starting with Tocumen Intl. Airport (PTY). It's about 35 mi from the center of the city, while Marcos A. Gelabert Intl. Airport (PAC) is 45 mi away from central Santa Isabel.