Explore 49 Luxury Hotels in North Central Florida

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Best Luxury Hotels in North Central Florida

Best Western Waldo Inn and Suites

Best Western Waldo Inn and Suites

17230 Ne Us Highway 301, Waldo, FL
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $96 total per night from Nov 2 to Nov 3
$96 total
Nov 2 - Nov 3
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
8.8/10 Excellent! (930 reviews)
A great alternative to the expensive hotels downtown for UF Homecoming. Very clean rooms.

Reviewed on Oct 21, 2025

Opens in a new windowBest Western Waldo Inn and Suites
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

3835 West US Highway 90, Lake City, FL
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $76 total per night from Oct 29 to Oct 30
$76 total
Oct 29 - Oct 30
Total with taxes and fees
An outdoor pool is featured at this motel, along with free self parking. Guests will appreciate free perks like on-the-go breakfast and WiFi in public areas. ...
8.6/10 Excellent! (1,002 reviews)
Great Value, Clean, and Comfortable
Clean, simple, and exactly what I needed! Staff was super kind and helpful. Only slight complaint is it seemed the noise was sneaking through the door of my road-facing room, but it didn’t bother me once I went to bed.

Reviewed on Oct 17, 2025

Opens in a new windowAmericas Best Value Inn Lake City
Driftwood Inn

Driftwood Inn

2764 W US Hwy 90, Lake City, FL
Fully refundable
$61 nightly
The price is $69 total per night from Oct 26 to Oct 27
$69 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
7.8/10 Good! (747 reviews)
They were very nice and it was clean and comfortable.

Reviewed on Aug 31, 2025

Opens in a new windowDriftwood Inn
Palms Garden Inn

Palms Garden Inn

14113 S. US Hwy 441, I -75 Exit 414, Lake City, FL
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $73 total per night from Oct 26 to Oct 27
$73 total
Oct 26 - Oct 27
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Express check-out and laundry facilities are also provided.
7.4/10 Good! (567 reviews)
I reserved this hotel at a much lower rate than its competitors, so I came in with reasonable expectations. The check in was easy and the host was friendly. The room was pretty clean, although dated (but that was very much expected). I do want to make a point that other people review other hotels ...

Reviewed on Oct 5, 2025

Opens in a new windowPalms Garden Inn
Gainesville Lodge

Gainesville Lodge

413 West University Ave, Gainesville, FL
Fully refundableReserve now, pay when you stay
$300 nightly
The price is $338 total per night from Nov 14 to Nov 15
$338 total
Nov 14 - Nov 15
Total with taxes and fees
Free WiFi in public areas is available at this motel. Take advantage of the free self parking.
7.2/10 Good! (547 reviews)
The property is an old-style motel, but the rooms have been updated and are very lovely and cute, with plenty of K-cups and towels. My only complaint in the tiny, and I mean tiny (one can), refrigerator. Rooms need a small usable fridge, and a microwave would be a bonus. I would stay there again, ...

Reviewed on Oct 6, 2025

Opens in a new windowGainesville Lodge
WoodSpring Suites Gainesville I-75

WoodSpring Suites Gainesville I-75

5505 SW 41st Blvd, Gainesville, FL
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $72 total per night from Oct 26 to Oct 27
$72 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the express check-out. The front ...
6.2/10 (1,008 reviews)
Nice place

Reviewed on Sep 7, 2025

Opens in a new windowWoodSpring Suites Gainesville I-75
Days Inn by Wyndham Gainesville University I-75

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter, Gainesville, FL
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $81 total per night from Oct 26 to Oct 27
$81 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
5.4/10 (1,000 reviews)
The rooms need some up keeping and maintenance. However it was clean and accessible to near by restaurants, shops. It was worth for the cost of stay

Reviewed on Oct 13, 2025

Opens in a new windowDays Inn by Wyndham Gainesville University I-75
Baymont By Wyndham Gainesville I-75

Baymont By Wyndham Gainesville I-75

6901 NW 4th Boulevard, Gainesville, FL
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $82 total per night from Oct 27 to Oct 28
$82 total
Oct 27 - Oct 28
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling for business? Take advantage of the business center, laundry ...
5.2/10 (1,000 reviews)
Great

Reviewed on Sep 11, 2025

Opens in a new windowBaymont By Wyndham Gainesville I-75
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5 star hotels in North Central Florida

The Equestrian Hotel

The Equestrian Hotel

8510 NW 17th Lane, Ocala, FL
$296 nightly
The price is $330 total per night from Oct 27 to Oct 28
$330 total
Oct 27 - Oct 28
Total with taxes and fees
9.6/10 Exceptional! (555 reviews)

North Central Florida Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the North Central Florida luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in North Central Florida to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in North Central Florida will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in North Central Florida, and plan your next opulent escape.


North Central Florida hotels essential information

Accommodation
2,534 hotels
Lowest Price
$69
Highest Price
$338
Popular hotels
Baymont By Wyndham Gainesville I-75, Palms Garden Inn, Americas Best Value Inn Lake City, Driftwood Inn, Days Inn by Wyndham Gainesville University I-75, WoodSpring Suites Gainesville I-75, Best Western Waldo Inn and Suites, Gainesville Lodge

Popular Luxury Stays in North Central Florida

Recent North Central Florida Hotel Reviews By Fellow Wanderers

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