Explore 49 Luxury Hotels in North Central Florida

Name: Baymont By Wyndham Gainesville I-75
Price range: $78 total
Rating: 5.2

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Best Luxury Hotels in North Central Florida

Best Western Waldo Inn and Suites

17230 Ne Us Highway 301 Waldo FL

Fully refundableReserve now, pay when you stay

$102 nightly

$115 total

Jul 18 - Jul 19

Total with taxes and fees

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...

8.8/10 Excellent! (1,003 reviews)

"There was no breakfast, but great place to spend night for traveling. Not to many food choices. The staff was great and hotel clean."

Reviewed on Jul 6, 2026

Americas Best Value Inn Lake City

3835 West US Highway 90 Lake City FL

Fully refundableReserve now, pay when you stay

$61 nightly

$69 total

Jul 12 - Jul 13

Total with taxes and fees

An outdoor pool is featured at this motel, along with free self parking. Guests will appreciate free perks like on-the-go breakfast and WiFi in public areas. ...

8.6/10 Excellent! (1,005 reviews)

"Clean, comfortable, and safe. Inexpensive. Very nice stay."

Reviewed on Jul 10, 2026

Gainesville Lodge

413 West University Ave Gainesville FL

$85 nightly

$96 total

Jul 12 - Jul 13

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. A bar/lounge and a coffee shop are also provided.

8.6/10 Excellent! (61 reviews)

"Smaller hotel but friendly, clean good location"

Reviewed on Jul 3, 2026

Driftwood Inn

2764 W US Hwy 90 Lake City FL

Fully refundableReserve now, pay when you stay

$50 nightly

$56 total

Jul 19 - Jul 20

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...

7.8/10 Good! (792 reviews)

"You definitely get what you pay for."

Reviewed on Jun 20, 2026

Palms Garden Inn

14113 S. US Hwy 441 Lake City FL

Fully refundableReserve now, pay when you stay

$65 nightly

$73 total

Jul 12 - Jul 13

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Express check-out and laundry facilities are also provided.

7.6/10 Good! (632 reviews)

"Good cold AC."

Reviewed on Jul 9, 2026

WoodSpring Suites Gainesville I-75

5505 SW 41st Blvd Gainesville FL

Fully refundableReserve now, pay when you stay

$63 nightly

$71 total

Jul 12 - Jul 13

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the express check-out. The front ...

6.2/10 (1,003 reviews)

"Great Hotel to stay for short term"

Reviewed on Jul 2, 2026

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL

Fully refundableReserve now, pay when you stay

$65 nightly

$73 total

Jul 13 - Jul 14

Total with taxes and fees

This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...

5.6/10 (1,006 reviews)

"The ladies room in the lobby was filthy. There were toilet paper on the floor and both toilets needed cleaning. There were lights out in the ladies room also, making it very dark in there. My husband said the men's room was fine. The rug in our room was torn up and made it dangerous for walking. ..."

Reviewed on Jul 7, 2026

Baymont By Wyndham Gainesville I-75

6901 NW 4th Boulevard Gainesville FL

Fully refundableReserve now, pay when you stay

$69 nightly

$78 total

Jul 12 - Jul 13

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling for business? Take advantage of the business center, laundry ...

5.2/10 (1,003 reviews)

"Dog barking in room across ours. Room and facility in poor condition. King size bed with 2 very small pillows"

Reviewed on Jul 8, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5 star hotels in North Central Florida

The Equestrian Hotel

8510 NW 17th Lane Ocala FL

$263 nightly

$293 total

Jul 12 - Jul 13

Total with taxes and fees

9.8/10 Exceptional! (708 reviews)

North Central Florida Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the North Central Florida luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in North Central Florida to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in North Central Florida will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in North Central Florida, and plan your next opulent escape.

North Central Florida hotels essential information

Accommodation	2,755 hotels
Lowest Price	$56
Highest Price	$293
Popular hotels	Baymont By Wyndham Gainesville I-75, Palms Garden Inn, Americas Best Value Inn Lake City, Driftwood Inn, Days Inn by Wyndham Gainesville University I-75, WoodSpring Suites Gainesville I-75, Best Western Waldo Inn and Suites, Gainesville Lodge