Book Hotels in Matthews, MO

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Matthews hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Oct 18 to Oct 19
$108 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Everything was up to par, good was excellent."

Reviewed on Oct 8, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

2.5 out of 5
2179 Gill Plaza Drive Dexter MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $111 total per night from Oct 18 to Oct 19
$111 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Relax with a drink at the bar/lounge and enjoy perks like free self parking and free WiFi. A 24-hour business ...
"Really nice place to look brand new that was good. TVs were updated. I enjoyed it. Thank you for having me."

Reviewed on Oct 6, 2026

Opens in a new windowHampton Inn By Hilton Dexter
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $120 total per night from Oct 18 to Oct 19
$120 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. ...
"Loved the modern, CLEAN, room and staff was extremely friendly and helpful. We were greeted and served by "Brittany" at check-in who was so nice and friendly and even gave us dinner suggestions. We would definitely stay here again!"

Reviewed on Oct 8, 2026

Opens in a new windowHampton Inn Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $96 total per night from Oct 11 to Oct 12
$96 total
Oct 11 - Oct 12
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour ...
"The greeting was warm and gracious. The property was well maintained. Only a couple of things: the tub was old with some stains also true if commode. The TV connect was in and out. The room was immaculate but theattress needed to be replaced. Overall mixed reviews but the price point was a plus."

Reviewed on Oct 7, 2026

Opens in a new windowBest Western Plus Sikeston I-55
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 out of 5
600 US-61 Portageville MO
Free self parking is available and the motel's front desk is staffed around-the-clock. A garden is also provided.
"Plain outside, nice room, inside of microwave had rust, smoke detector missing, very low price was nice."

Reviewed on Sep 15, 2026

Get rates
Opens in a new windowNew Orleans Inn Portageville
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $76 total per night from Nov 1 to Nov 2
$76 total
Nov 1 - Nov 2
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was ..."

Reviewed on Oct 9, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Fully refundableReserve now, pay when you stay
$57 nightly
The price is $65 total per night from Oct 15 to Oct 16
$65 total
Oct 15 - Oct 16
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like on-the-go breakfast and WiFi in ...
Opens in a new windowSuper 8 by Wyndham Sikeston/Miner Area
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
Fully refundable
$66 nightly
The price is $74 total per night from Oct 11 to Oct 12
$74 total
Oct 11 - Oct 12
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 24-hour ...
Opens in a new windowThe Riverstone Hotel Charleston-Sikeston
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $115 total per night from Oct 18 to Oct 19
$115 total
Oct 18 - Oct 19
Total with taxes and fees
This hotel features an indoor pool, a gym, and a restaurant. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink at the ...
Opens in a new windowFairfield Inn & Suites by Marriott Sikeston
Don't see what you're looking for?
See all available properties in Matthews
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Matthews?
Family vacations are where wonderful memories are made, but it's no secret that traveling with children can be a challenge. These kid-friendly Matthews hotels come with perks that aim to keep guests of all ages comfortable and happy: Unpack your bags at Hampton Inn Sikeston. It comes with complimentary breakfast, a swimming pool and a flair for making families feel welcome. Also consider Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel. It offers complimentary breakfast, a swimming pool and ample opportunities for precious family time.
Where can I find cheap hotels in Matthews?
At Travelocity you'll find really nice hotels in Matthews at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Matthews rather than in Matthews. We may find you even better rates, too.
How do I find the best Matthews hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Matthews then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Matthews?
The cheapest hotel in Matthews is $65. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Matthews?
There are 41 hotels in Matthews on Travelocity.
What are the best hotels in Matthews?
Matthews has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Matthews for you!
When is the best time to visit Matthews?
If you want the joy of a fun-filled trip in peak season, visit Matthews during June, August and October. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, September and November.
When is the cheapest time to stay in Matthews?
Based on historic data is usually the cheapest month to visit Matthews. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Matthews?
There are multiple hotels in Matthews that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Matthews. We have plenty of kid-friendly hotels in Matthews to choose from on Travelocity!
Why book a hotel in Matthews through Travelocity?
Because we have the top hotels in Matthews! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Matthews on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Matthews hotel reviews by fellow wanderers

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

4 out of 5
Posted less than an hour ago
Travelocity Verified Review
"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was about $30 less than other rooms that were available in the area so it was quite a value in my opinion."
A verified traveler stayed at Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston

Explore More Ways to Travel with Travelocity