Book Hotels in Matthews, MO

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Matthews hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Jul 26 to Jul 27
$128 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"It was all good."

Reviewed on Jul 19, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $125 total per night from Jul 30 to Jul 31
$125 total
Jul 30 - Jul 31
Total with taxes and fees
This hotel features an indoor pool, a gym, and a restaurant. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink at the ...
"Friendly staff, great breakfast, nice amenities"

Reviewed on Jul 19, 2026

Opens in a new windowFairfield Inn & Suites by Marriott Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $120 total per night from Aug 16 to Aug 17
$120 total
Aug 16 - Aug 17
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. ...
"Fast checking in and out. Very friendly staff and abundant complimentary breakfast. Spacious room and we liked having a walk in shower. There was plenty of green space to walk our small dog. The only complaint we had is that when we sat on the sofa, the cushion covers came off. They did not zip securely ..."

Reviewed on Jul 19, 2026

Opens in a new windowHampton Inn Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Fully refundable
$91 nightly
The price is $104 total per night from Aug 9 to Aug 10
$104 total
Aug 9 - Aug 10
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"Great stay"

Reviewed on Jul 19, 2026

Opens in a new windowHoliday Inn Express & Suites Sikeston Southwest by IHG
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $103 total per night from Aug 9 to Aug 10
$103 total
Aug 9 - Aug 10
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour ...
"Clean and comfortable room with good free breakfast"

Reviewed on Jul 18, 2026

Opens in a new windowBest Western Plus Sikeston I-55
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 out of 5
600 US-61 Portageville MO
Fully refundableReserve now, pay when you stay
$52 nightly
The price is $56 total per night from Jul 26 to Jul 27
$56 total
Jul 26 - Jul 27
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. A garden is also provided.
"the staff is always nice when I stay there"

Reviewed on Jul 21, 2026

Opens in a new windowNew Orleans Inn Portageville
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $77 total per night from Aug 9 to Aug 10
$77 total
Aug 9 - Aug 10
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
"I had a stay at this hotel. The rooms were clean, comfortable, and well maintained. The staff was friendly, professional, and always willing to help. The location was in a convenient place for us to take a quick rest The breakfast was delicious with plenty of options, and the overall atmosphere was ..."

Reviewed on Jul 4, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

2.5 out of 5
2179 Gill Plaza Drive Dexter MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $110 total per night from Aug 2 to Aug 3
$110 total
Aug 2 - Aug 3
Total with taxes and fees
A gym is on site and the staff is available around-the-clock at the 24-hour front desk.
Opens in a new windowHampton Inn By Hilton Dexter
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Aug 3 to Aug 4
$72 total
Aug 3 - Aug 4
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like on-the-go breakfast and WiFi in ...
Opens in a new windowSuper 8 by Wyndham Sikeston/Miner Area
Don't see what you're looking for?
See all available properties in Matthews
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Matthews?
Family vacations are where wonderful memories are made, but it's no secret that traveling with children can be a challenge. These kid-friendly Matthews hotels come with perks that aim to keep guests of all ages comfortable and happy: Unpack your bags at Hampton Inn Sikeston. It comes with complimentary breakfast, a swimming pool and a flair for making families feel welcome. Also consider Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel. It offers complimentary breakfast, a swimming pool and ample opportunities for precious family time.
Where can I find cheap hotels in Matthews?
At Travelocity you'll find really nice hotels in Matthews at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Matthews rather than in Matthews. We may find you even better rates, too.
How do I find the best Matthews hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Matthews then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Matthews?
The cheapest hotel in Matthews is $56. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Matthews?
There are 47 hotels in Matthews on Travelocity.
What are the best hotels in Matthews?
Matthews has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Matthews for you!
When is the best time to visit Matthews?
If you want the joy of a fun-filled trip in peak season, visit Matthews during June, August and October. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, September and November.
When is the cheapest time to stay in Matthews?
Based on historic data is usually the cheapest month to visit Matthews. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Matthews?
There are multiple hotels in Matthews that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Matthews. We have plenty of kid-friendly hotels in Matthews to choose from on Travelocity!
Why book a hotel in Matthews through Travelocity?
Because we have the top hotels in Matthews! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Matthews on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Matthews hotel reviews by fellow wanderers

New Orleans Inn Portageville

New Orleans Inn Portageville

5 out of 5
Posted 6 hours ago
Travelocity Verified Review
"the staff is always nice when I stay there"
A verified traveler stayed at New Orleans Inn Portageville
New Orleans Inn Portageville

Explore More Ways to Travel with Travelocity