Book Hotels in Matthews, MO
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Matthews hotels

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $110 total per night from Nov 27 to Nov 28
$110 total
Nov 27 - Nov 28
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Staff are wonderful, kind and welcoming! The happy hour is a great way to get out of your room and socialize. Lots of yummy food and drinks.
Reviewed on Nov 17, 2025

Pear Tree Inn Sikeston
2602 E Malone Avenue Sikeston MO
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $89 total per night from Nov 30 to Dec 1
$89 total
Nov 30 - Dec 1
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Grat as usual!
Reviewed on Nov 11, 2025

Fairfield Inn & Suites by Marriott Sikeston
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $114 total per night from Nov 28 to Nov 29
$114 total
Nov 28 - Nov 29
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Guests will appreciate ...
everything was great
Reviewed on Nov 13, 2025

Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $108 total per night from Nov 29 to Nov 30
$108 total
Nov 29 - Nov 30
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. ...
The place was nice and clean
Reviewed on Nov 17, 2025

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
100 Matthews Lane Sikeston MO
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $74 total per night from Nov 24 to Nov 25
$74 total
Nov 24 - Nov 25
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide ...
Not a great variety, cereal waffles muffins, no fruit
Reviewed on Nov 16, 2025

Best Western Plus Sikeston
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $90 total per night from Nov 30 to Dec 1
$90 total
Nov 30 - Dec 1
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour ...
Friendly staff, super clean, great breakfast. What else can you ask for at this price point?
Reviewed on Nov 12, 2025

Travelodge by Wyndham Dexter
1608 E Business US 60 Dexter MO
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Nov 23 to Nov 24
$98 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the business center. A restaurant, ...
Clean room, and the staff was courteous
Reviewed on Nov 10, 2025

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Nov 23 to Nov 24
$72 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
This was a really great stay, which was part of my long roadtrip. The hotel was right off the interstate & wasn't too noisy. My room was pretty big which I really enjoyed! The bed was super comfy. The front desk woman was super friendly and welcoming. I was able to get Door Dash to deliver to the ...
Reviewed on Nov 18, 2025

Dexter Inn
1807 W Business US Highway 60 Dexter MO
Fully refundable
$65 nightly
The price is $73 total per night from Nov 23 to Nov 24
$73 total
Nov 23 - Nov 24
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Staff at the 24-hour front desk ...
Great for a small town mom and pop hotel. I’ll probably come here a lot more
Reviewed on Nov 1, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Matthews hotel reviews by fellow wanderers

Days Inn and Suites by Wyndham Sikeston
5 out of 5
Posted 4 days ago
Travelocity Verified Review
"This was a really great stay, which was part of my long roadtrip. The hotel was right off the interstate & wasn't too noisy. My room was pretty big which I really enjoyed! The bed was super comfy. The front desk woman was super friendly and welcoming. I was able to get Door Dash to deliver to the location so that was a plus! They had quite a lot of items for breakfast, so I was surprised about that for a Days Inn. Only thing I didn't like was lack of parking, but overall, I would definitely stay here again if I come back to the area."
A verified traveler stayed at Days Inn and Suites by Wyndham Sikeston






