Book Hotels in Matthews, MO
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Matthews hotels

Hampton Inn By Hilton Dexter
2179 Gill Plaza Drive Dexter MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $110 total per night from Apr 5 to Apr 6
$110 total
Apr 5 - Apr 6
Total with taxes and fees
Stay at this hotel in Dexter. Popular attractions The Heritage House and Keller Veteran Memorial are located nearby.
Great place, nice and clean
Reviewed on Mar 27, 2026

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Apr 5 to Apr 6
$108 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
We will definitely be back! We travel from Wisconsin to Texas at least 2 times a year to visit family and we like to break our trip up with an overnight stay. This Drury Inn in Siikeston, Missouri will be our home away from
Reviewed on Mar 28, 2026

Fairfield Inn & Suites by Marriott Sikeston
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $114 total per night from Apr 3 to Apr 4
$114 total
Apr 3 - Apr 4
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Guests will appreciate ...
Perfect
Reviewed on Mar 27, 2026

Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $112 total per night from Apr 12 to Apr 13
$112 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. ...
Lovely facilities. Friendly staff.
Reviewed on Mar 27, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr Sikeston MO
Fully refundable
$93 nightly
The price is $105 total per night from Apr 12 to Apr 13
$105 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Clean rooms, friendly staff and convenient location.
Reviewed on Mar 23, 2026

Best Western Plus Sikeston I-55
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $106 total per night from Apr 2 to Apr 3
$106 total
Apr 2 - Apr 3
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour ...
Room was clean, breakfast was good, staff was friendly
Reviewed on Mar 27, 2026

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
100 Matthews Lane Sikeston MO
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $75 total per night from Apr 2 to Apr 3
$75 total
Apr 2 - Apr 3
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide ...
Stayed here as we were just passing through the area. Room was clean. Pillows were not very soft. Breakfast was very limited. Was as expected for the price.
Reviewed on Mar 28, 2026

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $78 total per night from Mar 31 to Apr 1
$78 total
Mar 31 - Apr 1
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
There were roaches crawling up the wall when we went in and the outside was horrible! Looked like a vacant building!! I want my money back
Reviewed on Mar 24, 2026

Super 8 by Wyndham Sikeston/Miner Area
2609 E Malone Ave Sikeston MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Mar 31 to Apr 1
$72 total
Mar 31 - Apr 1
Total with taxes and fees
Free self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate free perks like on-the-go breakfast and WiFi in ...
Room was supposed to be non smoking room but smelled of smoke.
Reviewed on Mar 16, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Matthews hotel reviews by fellow wanderers

New Orleans Inn Portageville
5 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Room was clean. Appeared to have been freshly painted and carpeted. Bathroom walls were a little rough, but nothing that affected our stay. Parking lot was bright and we were able to pull our truck right up to our door. We just needed a place to rest our heads for 7 or 8 hours. This was perfect for the price. The woman who checked us in was very sweet. "
A verified traveler stayed at New Orleans Inn Portageville





