Book Hotels in Greencastle, MO

Start date: Check-in selected.
To Date
End date: Check-out

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Greencastle hotels

New tiny home in an incredible private setting among all nature has to offer.

New tiny home in an incredible private setting among all nature has to offer.

Kirksville MO
This cabin featured laundry facilities and barbecue grills.
The host was extremely welcoming and communicated well. They had a stocked kitchen for us with food and coffee.

Reviewed on Nov 18, 2025

Get rates
Opens in a new windowNew tiny home in an incredible private setting among all nature has to offer.
Country Cabin In The Woods

Country Cabin In The Woods

Kirksville MO
This cabin featured laundry facilities and barbecue grills.
good!

Reviewed on Sep 25, 2025

Get rates
Opens in a new windowCountry Cabin In The Woods
Holiday Inn Express & Suites Kirksville - University Area by IHG

Holiday Inn Express & Suites Kirksville - University Area by IHG

2.5 out of 5
2523 South Franklin St. Kirksville MO
Fully refundable
The price is $130 total per night from Feb 14 to Feb 15
$130 total
per night
Feb 14 - Feb 15
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Everything was awesome.

Reviewed on Dec 17, 2025

Opens in a new windowHoliday Inn Express & Suites Kirksville - University Area by IHG
Super 8 by Wyndham Kirksville-University Area

Super 8 by Wyndham Kirksville-University Area

2.5 out of 5
1101 Country Club Dr Kirksville MO
Fully refundableReserve now, pay when you stay
The price is $73 total per night from Feb 4 to Feb 5
$73 total
per night
Feb 4 - Feb 5
This hotel features free WiFi in public areas, laundry facilities, and free parking. Guests will appreciate freebies like buffet breakfast and free self parking. ...
Simple clean room. Staff was extreemly friendly.

Reviewed on Jan 6, 2026

Opens in a new windowSuper 8 by Wyndham Kirksville-University Area
Hampton Inn Kirksville

Hampton Inn Kirksville

2.5 out of 5
2604 N. Baltimore Street Kirksville MO
Fully refundableReserve now, pay when you stay
The price is $129 total per night from Feb 15 to Feb 16
$129 total
per night
Feb 15 - Feb 16
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Estuvimos solo una noche y nos gustó mucho, todo muy limpio, el servicio exelente, lo recomiendo al 100%

Reviewed on Jan 11, 2026

Opens in a new windowHampton Inn Kirksville
Thousand Hills

Thousand Hills

2 out of 5
20431 Missouri 157 Kirksville MO
A restaurant is available at this hotel. Take advantage of the free self parking.
Room was in great shape and close to actities I did

Reviewed on Nov 9, 2025

Get rates
Opens in a new windowThousand Hills
Baymont by Wyndham Kirksville University Area

Baymont by Wyndham Kirksville University Area

2.5 out of 5
2702 South Franklin Kirksville MO
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
This older motel is badly in need of a complete renovation. The facilities were barely adequate with the shower, toilet and bathroom door needing service and repair. The staff was attentive, and the breakfast was very good. My favorite part was the warm baked goods with which we were treated ...

Reviewed on Dec 9, 2025

Get rates
Opens in a new windowBaymont by Wyndham Kirksville University Area
Knights Inn Kirksville

Knights Inn Kirksville

1.5 out of 5
2521 South Franklin Street Kirksville MO
Fully refundableReserve now, pay when you stay
The price is $76 total per night from Jan 16 to Jan 17
$76 total
per night
Jan 16 - Jan 17
Free WiFi in public areas is available at this motel. Take advantage of the free self parking.
Room was clean… quiet…

Reviewed on Nov 19, 2025

Opens in a new windowKnights Inn Kirksville
Days Inn by Wyndham Kirksville

Days Inn by Wyndham Kirksville

2 out of 5
3805 S Baltimore St Kirksville MO
Fully refundableReserve now, pay when you stay
The price is $73 total per night from Jan 18 to Jan 19
$73 total
per night
Jan 18 - Jan 19
This hotel features an indoor pool and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
There were roaches in the room. The toilet stool lid had been melted by some kind of chemicals it looks like and the door stop for the bathroom door is right where you get out of the tub and is a major fall hazard insurance liability and probably not up to violation code in multiple parts of the ...

Reviewed on Jan 9, 2026

Opens in a new windowDays Inn by Wyndham Kirksville
Don't see what you're looking for?
See all available properties in Greencastle
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Greencastle?
Family trips are where wonderful memories are made, but traveling with young ones can be challenging. These kid-friendly Greencastle hotels offer perks designed to keep adventurers of all ages relaxed and happy: Your entourage will enjoy staying at Hampton Inn Kirksville. A swimming pool and complimentary breakfast are among the things that help make this property a popular option. Otherwise, spend your Greencastle escape at Quality Inn Kirksville. Take advantage of a pillowtop mattress, front desk services and more here.
Where can I find cheap hotels in Greencastle?
At Travelocity you'll find really nice hotels in Greencastle at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Greencastle rather than in Greencastle. We may find you even better rates, too.
How do I find the best Greencastle hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Greencastle then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Greencastle?
The cheapest hotel in Greencastle is $73. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Greencastle?
There are 49 hotels in Greencastle on Travelocity.
What are the best hotels in Greencastle?
Greencastle has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Greencastle for you!
When is the best time to visit Greencastle?
If you want the joy of a fun-filled trip in peak season, visit Greencastle during March, May and June. If you'd prefer the peace of off-season, book a stay during quieter months, such as December, January and February.
When is the cheapest time to stay in Greencastle?
Based on historic data is usually the cheapest month to visit Greencastle. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Greencastle?
There are multiple hotels in Greencastle that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Greencastle. We have plenty of kid-friendly hotels in Greencastle to choose from on Travelocity!
Why book a hotel in Greencastle through Travelocity?
Because we have the top hotels in Greencastle! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Greencastle on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Greencastle hotel reviews by fellow wanderers

Hampton Inn Kirksville

Hampton Inn Kirksville

5 out of 5
Posted 4 days ago
Travelocity Verified Review
"Estuvimos solo una noche y nos gustó mucho, todo muy limpio, el servicio exelente, lo recomiendo al 100% "
A verified traveler stayed at Hampton Inn Kirksville
Hampton Inn Kirksville