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Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Enjoy free breakfast at this spa Cape Girardeau hotel

Choose dates to view prices

Photo gallery for Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Exterior
Exterior
Premium bedding, down comforters, pillowtop beds, in-room safe
Indoor pool, open 8 AM to 11 PM, sun loungers
Free breakfast

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Laundry
  • Housekeeping

Explore the area

View in a map
3253 William Street, Cape Girardeau, MO, 63701
  • Place, Saint Francis Medical Center
    ‪6 min walk‬
  • Place, Southeast Missouri State University
    ‪6 min drive‬
  • Place, Isle Casino Cape Girardeau
    ‪8 min drive‬
  • Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪7 min drive‬

Room options

View all photos for Suite, 2 Queen Beds, Accessible (Roll-In Shower)

Suite, 2 Queen Beds, Accessible (Roll-In Shower) | Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Roll-In Shower)

8.0 out of 10
Very good
(5 reviews)
  • 400 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Roll-In Shower)

9.6 out of 10
Exceptional
(5 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed

9.6 out of 10
Exceptional
(32 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 2 Queen Beds

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds

9.6 out of 10
Exceptional
(52 reviews)
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 2 Queen Beds, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Mobility)

9.4 out of 10
Exceptional
(14 reviews)
  • 400 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Standard Room, 1 Queen Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room, 1 Queen Bed

9.2 out of 10
Wonderful
(5 reviews)
  • 400 sq ft
  • Sleeps 2
  • 1 Queen Bed

View all photos for Standard Room

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room

8.4 out of 10
Very good
(5 reviews)
  • 400 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 Bedroom (Feature)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 Bedroom (Feature)

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 2
  • 1 Queen Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Mobility)

10.0 out of 10
Exceptional
(2 reviews)
  • Sleeps 2
  • 1 King Bed

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Drury Plaza Hotel Cape Girardeau Conference Center

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  • Pool
  • Hot Tub
  • Breakfast included
  • Pet friendly
4.8 out of 5, Exceptional, 1,000 reviews
$90 nightly
The price is $102
Nov 2 - Nov 3
Total with taxes and fees
Drury Plaza Hotel Cape Girardeau Conference Center

About the neighborhood

Cape Girardeau

Near the airport.A stay at this hotel places you within half a mile (1 km) of Saint Francis Medical Center and 3 miles (5 km) of Saint Francis Healthcare System. Southeast Missouri Hospital and Cape Splash Family Aquatic Center are also within 3 miles (5 km).

What's nearby

  • Saint Francis Medical Center - 6 min walk - 0.4 miles
  • Southeast Missouri State University - 6 min drive - 3.7 miles
  • Riverfront Bridge Park - 7 min drive - 4.0 miles
  • Show Me Center - 7 min drive - 4.4 miles
  • Isle Casino Cape Girardeau - 8 min drive - 4.3 miles

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 10 min drive

Restaurants

  • ‪Chick-fil-A - ‬7 min walk
  • ‪Rhodes - ‬20 min walk
  • ‪McDonald's - ‬10 min walk
  • ‪Chili's Grill & Bar - ‬4 min walk
  • ‪White Castle - ‬10 min walk

About this property

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Enjoy free breakfast at this spa Cape Girardeau hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offers its guests a full-service spa, an indoor pool, and a fitness center. Public spaces have free WiFi and wired Internet. A business center and a meeting room are available. Free breakfast is served. Event space at this hotel measures 118 square feet (11 square meters) and includes conference space. The business-friendly Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG also features a vending machine, complimentary newspapers in the lobby, and laundry facilities. Self parking is free.

This Cape Girardeau hotel is smoke free.

  • 1 building
  • 102 guestrooms or units
  • 4 levels
  • 118 sq ft of conference space
  • 11 sq m of conference space
  • Breakfast available (free)
  • Poolside lounge chairs
  • Business facilities
  • Conference space
  • Dry cleaning
  • Self-service laundry
  • Front desk (24 hours)
  • Storage area for luggage
  • Front-desk safe
  • Newspapers in lobby (free)
  • Bellhop
  • No smoking on site
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offers 102 accommodations with safes and coffee/tea makers. Accommodations offer separate sitting areas. Pillowtop beds feature down comforters and premium bedding. A pillow menu is available. 52-inch flat-screen televisions come with premium cable channels. Bathrooms include complimentary toiletries and hair dryers.

Guests can surf the web using the complimentary wired and wireless Internet access. Business-friendly amenities include desks and phones; free local calls are provided (restrictions may apply). Housekeeping is provided daily.

Guests can indulge in a pampering treatment at the hotel's full-service spa.

Similar properties

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center
  • Pool
  • Hot Tub
  • Breakfast included
  • Pet friendly
4.8 out of 5, Exceptional, 1,000 reviews
$90 nightly
The price is $102
Nov 2 - Nov 3
Total with taxes and fees
Drury Plaza Hotel Cape Girardeau Conference Center

Property amenities

Family friendly

  • In-room microwave
  • Indoor pool
  • Laundry facilities
  • Mini-fridge

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking available

Food and drink

  • Free breakfast available

Things to do

  • Full-service spa
  • Gym
  • Indoor pool

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator

Room amenities

Entertainment

  • 52-inch flat-screen TV with premium cable channels

Bedroom

  • Down comforter
  • Pillow menu
  • Pillowtop mattress
  • Premium bedding

Bathroom

  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Food and drink

  • Coffee/tea maker
  • Microwave
  • Mini-fridge

More

  • Air conditioning (climate-controlled)
  • Connecting rooms available
  • Desk
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Separate sitting area

Policies

Check-in

Check-in start time: 3:00 PM; Check-in end time: anytime
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • No pets allowed

Children and extra beds

  • Children are welcome.
  • Cribs (infant beds) are not available.

Property payment types

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a smoke detector
This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, American Express, Discover, Diners Club, JCB International, and Carte Blanche. Cash is not accepted. For guests' safety, the property includes a smoke detector in each accommodation. Cashless payment methods are available for all transactions. This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG).

We should mention

  • Pool access available from 8 AM to 11 PM.
  • Connecting/adjoining rooms are subject to availability and can be requested by contacting the property at the number on your booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Holiday Inn Express Cape Girardeau I-55
Holiday Inn Express Hotel Cape Girardeau I-55
Holiday Inn Hotel I-55
Holiday Inn Express Hotel Suites Cape Girardeau I 55
Inn Express Cape Girarau I55
Holiday Inn Express Hotel Suites Cape Girardeau I 55
Holiday Inn Express Hotel Suites Cape Girardeau I 55 by IHG

Frequently asked questions

How close is Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG to the airport?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is 6.1 mi (10-min drive) away from the Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, the closest popular airport to the property.

How much does it cost to stay at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

As of Oct 23, 2025, prices found for a 1-night stay for 2 adults at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG on Nov 2, 2025 start from $95.0, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have an airport shuttle?

Airport shuttle services are not available at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offer free breakfast?

Yes, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offers free breakfast.

Is there a casino at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

No, there is no casino at this hotel, but Isle Casino Cape Girardeau (7-min drive) is nearby.

What time is check-in at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Check-in start time: 3:00 PM; Check-in end time: anytime.

Is there free parking at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

This hotel offers free self parking.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have a pool?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG features an indoor pool. Guests can enjoy pool access from 8 AM to 11 PM.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have a spa?

Yes, this hotel has a spa.

How close is Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG to downtown Cape Girardeau?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is 3.2 mi away from Cape Girardeau.