Explore top 2026 5 Star Hotels in Florida Keys
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Top Florida Keys 5 Star hotels
Cheeca Lodge & Spa
"The decor was updated a bit but then dated in other areas. The balcony cushions had stains and the carpet needed to be replaced."
Reviewed on Jun 23, 2026
Isla Bella Beach Resort & Spa
"It is a great location and Isla Bella Beach Resort in Marathon is a truly beautiful property that checks every box you could ask for in a Florida Keys getaway. The location is wonderful, the aesthetics are stunning, the cleanliness is impeccable and the amenities are plentiful and well maintained ..."
Reviewed on Jun 23, 2026
Florida Keys Resorts & 5 Star Hotels
Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Florida Keys to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Florida Keys 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Florida Keys before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Florida Keys hotel reviews by fellow wanderers
Playa Largo Resort & Spa, Autograph Collection
"We loved our stay! The hotel was in excellent condition and exceptionally clean. The restaurants were beautiful, well-maintained, and offered delicious food. We enjoyed both dinner and breakfast at La Marea Restaurant, and everything was absolutely delicious. All of the staff were friendly, welcoming, and helpful throughout our stay. We would definitely recommend this hotel and look forward to returning! ⭐⭐⭐⭐⭐"
