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Top Serra Mesa 3 Star hotels

Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $87 total per night from Mar 29 to Mar 30
$87 total
Mar 29 - Mar 30
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
7.8/10 Good! (3,295 reviews)
The receptionist was very helpful

Reviewed on Mar 16, 2026

Opens in a new windowBest Western Seven Seas
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $126 total per night from Apr 5 to Apr 6
$126 total
Apr 5 - Apr 6
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
8.2/10 Very Good! (2,341 reviews)
Nice hotel

Reviewed on Mar 16, 2026

Opens in a new windowHandlery Hotel
The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 out of 5
1055 1st Ave San Diego CA
Fully refundableReserve now, pay when you stay
$141 nightly
The price is $164 total per night from Apr 3 to Apr 4
$164 total
Apr 3 - Apr 4
Total with taxes and fees
A gym is featured at this hotel, along with valet parking. WiFi in public areas is free. A business center, a snack bar/deli, and a grocery/convenience store ...
8.6/10 Excellent! (1,528 reviews)
The staff was so sweet, valet was nice and easy, the room was clean, bed was comfortable, the view was so cute! And the hotel is within walking distance of so many things.

Reviewed on Mar 16, 2026

Opens in a new windowThe Bristol Hotel San Diego
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $123 total per night from Mar 23 to Mar 24
$123 total
Mar 23 - Mar 24
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
8/10 Very Good! (2,551 reviews)
Everything was except for the fact that the bathtub got clogged and the fridge didn’t make Anything cold

Reviewed on Mar 16, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $150 total per night from Apr 5 to Apr 6
$150 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9/10 Wonderful! (1,202 reviews)
Expensive parking!

Reviewed on Mar 16, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $182 total per night from Apr 5 to Apr 6
$182 total
Apr 5 - Apr 6
Total with taxes and fees
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
8.6/10 Excellent! (1,819 reviews)
The room was very nice and the staff accommodating! We went for a quick bachelorette weekend with 5 women. There was plenty of space for us and the location was ideal. Other than not enough mirror and garbage cans, it was perfect. 10/10 recommend and would definitely return.

Reviewed on Mar 16, 2026

Opens in a new windowThe Sofia Hotel
La Jolla Shores Hotel

La Jolla Shores Hotel

3 out of 5
8110 Camino Del Oro La Jolla CA
Fully refundableReserve now, pay when you stay
$245 nightly
The price is $281 total per night from Apr 12 to Apr 13
$281 total
Apr 12 - Apr 13
Total with taxes and fees
2 outdoor tennis courts, an outdoor pool, and a hot tub are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
8.8/10 Excellent! (1,375 reviews)
Renovations will make it better

Reviewed on Mar 15, 2026

Opens in a new windowLa Jolla Shores Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$189 nightly
The price is $217 total per night from Apr 5 to Apr 6
$217 total
Apr 5 - Apr 6
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
9/10 Wonderful! (4,165 reviews)
Great location and friendly staff

Reviewed on Mar 16, 2026

Opens in a new windowThe Dana on Mission Bay
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $209 total per night from Mar 31 to Apr 1
$209 total
Mar 31 - Apr 1
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
9.2/10 Wonderful! (3,483 reviews)
Large room.

Reviewed on Mar 16, 2026

Opens in a new windowBay Club Hotel & Marina
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

3 out of 5
2051 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$151 nightly
The price is $174 total per night from Apr 5 to Apr 6
$174 total
Apr 5 - Apr 6
Total with taxes and fees
A marina, 2 outdoor pools, and 2 outdoor tennis courts are all featured at this smoke-free hotel. Enjoy the 2 hot tubs and perks like free WiFi. A gym, a restaurant, ...
8.8/10 Excellent! (1,596 reviews)
Wonderful place to stay for a visit to San Diego. Nice rooms, scenic views of the marina, on site restaurant and bar, large heated pool and hot tub. Within 15-20 minutes’ drive of downtown and the airport. Playground, beach, and walking path across the street.

Reviewed on Mar 16, 2026

Opens in a new windowBest Western Plus Island Palms Hotel & Marina
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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