Find a Hotel in Serra Mesa
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Top hotels in Serra Mesa
Pendry San Diego
550 J Street, San Diego, CA
Fully refundableReserve now, pay when you stay
$310 nightly
The price is $360 total per night from Nov 9 to Nov 10
$360 total
Nov 9 - Nov 10
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"The room was perfect, the shower soap, and lotions smelled so good I bought some to take home. Beautiful hotel and easy to walk around gaslamp without need for uber. Walkable to train and trolly also! The hotel bar was very classy and staff went above and beyond!"
Reviewed on Oct 15, 2025
Hampton Inn & Suites by Hilton San Diego SeaWorld
3888 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $150 total per night from Oct 26 to Oct 27
$150 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features an outdoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the hot tub and free buffet breakfast ...
"The staff was amazing, even helped me get a list item from my Uber driver. An unexpected homeless camp showed up outside of the entry and the staff took care of the situation with speed, safety for guests as well as respect for the campers. I'm looking forward to stay again."
Reviewed on Oct 13, 2025
Manchester Grand Hyatt San Diego
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
$286 nightly
The price is $332 total per night from Oct 29 to Oct 30
$332 total
Oct 29 - Oct 30
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"We had a studio suite on the 38th floor and the view was amazing. It was a nice, spacious room, but the bathroom was so tiny and the bed was not very comfortable. The bellman mentioned that there are upgrades planned in the near future though..."
Reviewed on Oct 17, 2025
Hard Rock Hotel San Diego
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
$269 nightly
The price is $311 total per night from Oct 20 to Oct 21
$311 total
Oct 20 - Oct 21
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Best place to stay for city center activities. Close to everything and hotel is well-appointed."
Reviewed on Oct 13, 2025
San Diego Marriott La Jolla
4240 La Jolla Village Dr, La Jolla, CA
Fully refundableReserve now, pay when you stay
$197 nightly
The price is $227 total per night from Oct 26 to Oct 27
$227 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"I stayed with my daughter and two small dogs, on a king bed, room is pretty good size, had a little tiny balcony that I could open glass door. room is very clean, has table chair extra chair with ottoman, tv, fridge, coffee maker, bathroom shower gel, shampoo and conditioner. I personally loved pillows ..."
Reviewed on Oct 14, 2025
Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $186 total per night from Oct 26 to Oct 27
$186 total
Oct 26 - Oct 27
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Clean room"
Reviewed on Oct 12, 2025
DoubleTree by Hilton San Diego - Del Mar
11915 El Camino Real, San Diego, CA
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $136 total per night from Nov 16 to Nov 17
$136 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features an outdoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 9 conference rooms, free WiFi in public areas, ...
"Comfortable"
Reviewed on Oct 13, 2025
Hilton San Diego Mission Valley
901 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Oct 26 to Oct 27
$131 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Clean rooms, nice staff etc.."
Reviewed on Oct 13, 2025
Comfort Inn San Diego Airport At The Harbor
San Diego
$78 nightly
The price is $88 total per night from Nov 11 to Nov 12
$88 total
Nov 11 - Nov 12
Total with taxes and fees
This hotel features an outdoor pool and a rooftop terrace. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free full breakfast ...
"Had an early flight could not get breakfast and did notifier a to go breakfast."
Reviewed on Oct 15, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Serra Mesa Hotel Guide
Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.
Nowhere else can you find better deals on Serra Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Serra Mesa to find the perfect one to will fit your budget.
Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Serra Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.
Recent Serra Mesa hotel reviews by fellow wanderers
Comfort Inn San Diego Airport At The Harbor
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Clean, friendly, polite. Will stay there again!"
A verified traveler stayed at Comfort Inn San Diego Airport At The Harbor
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