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Top Cairo hotels

Charming cottage overlooking Lake Acre
Reviewed on May 29, 2025

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Reviewed on Jul 8, 2025

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!
Reviewed on Jun 30, 2025

Cozy cabins on beautiful Horseshoe Lake
Reviewed on Jun 23, 2025

Peaceful secluded cabin located near Horseshoe Lake
Reviewed on Jul 6, 2025

Quality Inn Charleston - Sikeston
Reviewed on Jun 22, 2025

Super 8 by Wyndham Charleston/Sikeston East MO
Reviewed on Jul 6, 2025

Quality Inn Cairo I-57
Reviewed on Jun 10, 2025

The Rested Duck Mallard Room
Reviewed on Apr 26, 2025
Cheap Cairo hotels

Quality Inn Cairo I-57
Cairo Hotel & Travel Guide\n
Travelocity customers dreaming about roaming in Cairo, should think about pre-booking a room as early as possible, as you won't find an abundance of room options in the vicinity of Cairo's center.
A fantastic choice for the times you want to stay within a short walk of the urban core of Cairo, is the Quality Inn.
The Quality Inn Charleston can be found about 12 miles (20 kilometers) from the town center of Cairo. Another hotel is the Super 8 Charleston MO, which is approximately 11 miles (17 kilometers) away. You might like to investigate the Americas Best Value Inn or the Quality Inn.
Once you've found the secrets of Cairo, how about you tour a little more of the area? The Southern Illinois vicinity is home to a number of great other cultural and scenic delights to offer. If you love nature, be sure to explore Southern Illinois's rural landscapes, rolling hills and prairies. In addition you could visit many of its farms. Wise travelers in this corner of United States of America often enjoy rock climbing, hiking and abseiling.
Metropolis is 30 miles (47 kilometers) to the east of Cairo and is where you'll find Super Museum and Americana Hollywood Museum. The Holiday Inn Express Metropolis and Super 8 Metropolis are a few of the great short and long-stay alternatives in Metropolis. 45 miles (76 kilometers) to the north of Cairo, you'll also find Marion, home to the Fairfield Inn and Suites by Marriott Marion and Comfort Suites Marion. Regardless of whether you're passing through or spending a few nights in Marion, be sure to check out the Kokopelli Golf Club and Marion Carnegie Library.
Just because you're taking a break from your usual habits, who's to say that you shouldn't expand your obsession with a day watching sports. Find Rent One Park 50 miles (81 kilometers) to the north of Cairo. Sports fans that hope to find a bed close to the action can select from the Holiday Inn Express Hotel & Suites Marion Northeast or the Comfort Inn Marion.
Cairo attracts visitors with some fantastic things to look at; learn more via our complete Cairo accommodation and attractions guide.
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Recent Cairo hotel reviews by fellow wanderers

Super 8 by Wyndham Charleston/Sikeston East MO
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