United Flight 5221 Deals & Information (2026/2027)

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United Flight 5221 Route Deals From $287

The cheapest prices found with in the last 7 days for return flights were $285 and $287 for one-way flights to Denver Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Apr 24 - Sun, Apr 26
AMA
Rick Husband Amarillo Intl.
DEN
Denver Intl.
$285 Roundtrip, found 3 days ago
$285
Roundtrip
found 3 days ago
Select United flight, departing Fri, Apr 24 from Rick Husband Amarillo Intl. to Denver Intl., returning Sun, Apr 26, priced at $285 found 3 days ago
Fri, Aug 21 - Thu, Aug 27
AMA
Rick Husband Amarillo Intl.
DEN
Denver Intl.
$287 Roundtrip, found 3 days ago
$287
Roundtrip
found 3 days ago
Select United flight, departing Fri, Aug 21 from Rick Husband Amarillo Intl. to Denver Intl., returning Thu, Aug 27, priced at $287 found 3 days ago
Fri, Apr 24 - Sun, Apr 26
AMA
Rick Husband Amarillo Intl.
DEN
Denver Intl.
$326 Roundtrip, found 3 days ago
$326
Roundtrip
found 3 days ago
Select United flight, departing Fri, Apr 24 from Rick Husband Amarillo Intl. to Denver Intl., returning Sun, Apr 26, priced at $326 found 3 days ago
Fri, Apr 24 - Sun, Apr 26
AMA
Rick Husband Amarillo Intl.
DEN
Denver Intl.
$357 Roundtrip, found 3 days ago
$357
Roundtrip
found 3 days ago
Select United flight, departing Fri, Apr 24 from Rick Husband Amarillo Intl. to Denver Intl., returning Sun, Apr 26, priced at $357 found 3 days ago

Frequently asked questions

What route does flight number UA5221 take?
UA5221 is used on a range of routes. Most often, UA5221 flies straight from Lambert Field to Denver, CO Airport (DEN-Denver Intl.). If that's your chosen flight path, you'll be airborne for 2 hours and 26 minutes.
What terminal does UA5221 fly out of?
If you're heading off from STL, you'll probably board the plane from Terminal 1. The most traveled route for flight number UA5221 is STL to DEN, which is a nonstop flight.
What kind of plane is on flight number UA5221?
It's highly likely you'll be enjoying the services of an Embraer 175 if you've reserved a seat on flight number UA5221 from St. Louis, MO Airport (STL-Lambert-St. Louis Intl.) to Denver, CO Airport (DEN-Denver Intl.). It's the most commonly used aircraft on this route.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your UA5221 flight with Travelocity, please visit our Customer Service Portal.