United Flight 4521 Deals & Information (2026/2027)

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United Flight 4521 Route Deals From $142

The cheapest prices found with in the last 7 days for return flights were $189 and $142 for one-way flights to McGhee Tyson for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Apr 1 - Sun, Apr 5
ORD
O'Hare Intl.
TYS
McGhee Tyson
$189 Roundtrip, found 1 day ago
$189
Roundtrip
found 1 day ago
Select United flight, departing Wed, Apr 1 from O'Hare Intl. to McGhee Tyson, returning Sun, Apr 5, priced at $189 found 1 day ago
Wed, Jan 21 - Sun, Jan 25
ORD
O'Hare Intl.
TYS
McGhee Tyson
$192 Roundtrip, found 5 days ago
$192
Roundtrip
found 5 days ago
Select United flight, departing Wed, Jan 21 from O'Hare Intl. to McGhee Tyson, returning Sun, Jan 25, priced at $192 found 5 days ago
Fri, Feb 6 - Sun, Feb 8
ORD
O'Hare Intl.
TYS
McGhee Tyson
$194 Roundtrip, found 2 days ago
$194
Roundtrip
found 2 days ago
Select United flight, departing Fri, Feb 6 from O'Hare Intl. to McGhee Tyson, returning Sun, Feb 8, priced at $194 found 2 days ago
Sat, Feb 7 - Sun, Feb 8
ORD
O'Hare Intl.
TYS
McGhee Tyson
$194 Roundtrip, found 2 days ago
$194
Roundtrip
found 2 days ago
Select United flight, departing Sat, Feb 7 from O'Hare Intl. to McGhee Tyson, returning Sun, Feb 8, priced at $194 found 2 days ago
Thu, Jan 15 - Tue, Jan 20
ORD
O'Hare Intl.
TYS
McGhee Tyson
$204 Roundtrip, found 5 days ago
$204
Roundtrip
found 5 days ago
Select United flight, departing Thu, Jan 15 from O'Hare Intl. to McGhee Tyson, returning Tue, Jan 20, priced at $204 found 5 days ago
Fri, Jan 23 - Sun, Jan 25
ORD
O'Hare Intl.
TYS
McGhee Tyson
$222 Roundtrip, found 5 days ago
$222
Roundtrip
found 5 days ago
Select United flight, departing Fri, Jan 23 from O'Hare Intl. to McGhee Tyson, returning Sun, Jan 25, priced at $222 found 5 days ago
Fri, Jan 23 - Sun, Jan 25
ORD
O'Hare Intl.
TYS
McGhee Tyson
$227 Roundtrip, found 5 days ago
$227
Roundtrip
found 5 days ago
Select United flight, departing Fri, Jan 23 from O'Hare Intl. to McGhee Tyson, returning Sun, Jan 25, priced at $227 found 5 days ago
Thu, Mar 26 - Sun, Mar 29
ORD
O'Hare Intl.
TYS
McGhee Tyson
$240 Roundtrip, found 3 days ago
$240
Roundtrip
found 3 days ago
Select United flight, departing Thu, Mar 26 from O'Hare Intl. to McGhee Tyson, returning Sun, Mar 29, priced at $240 found 3 days ago
Wed, Apr 1 - Sun, Apr 5
ORD
O'Hare Intl.
TYS
McGhee Tyson
$248 Roundtrip, found 1 day ago
$248
Roundtrip
found 1 day ago
Select United flight, departing Wed, Apr 1 from O'Hare Intl. to McGhee Tyson, returning Sun, Apr 5, priced at $248 found 1 day ago
Thu, Feb 12 - Sun, Feb 15
ORD
O'Hare Intl.
TYS
McGhee Tyson
$255 Roundtrip, found 14 hours ago
$255
Roundtrip
found 14 hours ago
Select United flight, departing Thu, Feb 12 from O'Hare Intl. to McGhee Tyson, returning Sun, Feb 15, priced at $255 found 14 hours ago

Frequently asked questions

What route does flight number UA4521 take?
You'll arrive into ORD from CLE if you're traveling on flight number UA4521. You'll be in the air for 1 hour and 28 minutes during this journey. It's also worthwhile noting that the service conveniently operates non-stop.
What kind of plane is on flight number UA4521?
You'll likely be boarding a Canadair (Bombardier) Regional Jet 550 if you're on flight number UA4521. Generally, this flight takes off from Hopkins Intl. Airport (CLE) and touches down at Chicago, IL Airport (ORD-O'Hare Intl.).
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your UA4521 flight with Travelocity, please visit our Customer Service Portal.