American Airlines Flight 5378 Deals & Information (2025/2026)

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American Airlines Flight 5378 Route Deals From $169

The cheapest prices found with in the last 7 days for return flights were $189 and $169 for one-way flights to McGhee Tyson for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Oct 21 - Tue, Oct 28
ORD
O'Hare Intl.
TYS
McGhee Tyson
$189 Roundtrip, found 13 hours ago
$189
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Oct 21 from O'Hare Intl. to McGhee Tyson, returning Tue, Oct 28, priced at $189 found 13 hours ago
Mon, Aug 4 - Sat, Aug 9
ORD
O'Hare Intl.
TYS
McGhee Tyson
$193 Roundtrip, found 5 days ago
$193
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Aug 4 from O'Hare Intl. to McGhee Tyson, returning Sat, Aug 9, priced at $193 found 5 days ago
Wed, Jul 2 - Tue, Jul 8
ORD
O'Hare Intl.
TYS
McGhee Tyson
$199 Roundtrip, found 5 days ago
$199
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jul 2 from O'Hare Intl. to McGhee Tyson, returning Tue, Jul 8, priced at $199 found 5 days ago
Wed, Oct 8 - Sat, Oct 11
ORD
O'Hare Intl.
TYS
McGhee Tyson
$214 Roundtrip, found 1 day ago
$214
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 8 from O'Hare Intl. to McGhee Tyson, returning Sat, Oct 11, priced at $214 found 1 day ago
Wed, Oct 8 - Sat, Oct 11
ORD
O'Hare Intl.
TYS
McGhee Tyson
$219 Roundtrip, found 1 day ago
$219
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 8 from O'Hare Intl. to McGhee Tyson, returning Sat, Oct 11, priced at $219 found 1 day ago
Fri, Jul 18 - Mon, Jul 21
ORD
O'Hare Intl.
TYS
McGhee Tyson
$223 Roundtrip, found 5 hours ago
$223
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Fri, Jul 18 from O'Hare Intl. to McGhee Tyson, returning Mon, Jul 21, priced at $223 found 5 hours ago
Tue, Oct 21 - Tue, Oct 28
ORD
O'Hare Intl.
TYS
McGhee Tyson
$224 Roundtrip, found 13 hours ago
$224
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Oct 21 from O'Hare Intl. to McGhee Tyson, returning Tue, Oct 28, priced at $224 found 13 hours ago
Mon, Aug 4 - Sat, Aug 9
ORD
O'Hare Intl.
TYS
McGhee Tyson
$228 Roundtrip, found 5 days ago
$228
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Aug 4 from O'Hare Intl. to McGhee Tyson, returning Sat, Aug 9, priced at $228 found 5 days ago
Fri, Jul 18 - Mon, Jul 21
ORD
O'Hare Intl.
TYS
McGhee Tyson
$233 Roundtrip, found 5 hours ago
$233
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Fri, Jul 18 from O'Hare Intl. to McGhee Tyson, returning Mon, Jul 21, priced at $233 found 5 hours ago
Wed, Jul 9 - Wed, Jul 16
ORD
O'Hare Intl.
TYS
McGhee Tyson
$238 Roundtrip, found 6 hours ago
$238
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Jul 9 from O'Hare Intl. to McGhee Tyson, returning Wed, Jul 16, priced at $238 found 6 hours ago

Frequently asked questions

What route does flight number AA5378 take?
AA5378 takes approximately 2 hours and 32 minutes to fly non-stop from MHT to CLT. We all know there's magic in the destination, but half the fun is in the journey!
How often is AA5378 on time?
About 92% of AA5378 flights depart on time --- so if you're flying from Manchester, NH Airport (MHT-Manchester-Boston Regional) to Charlotte-Douglas Intl. Airport (CLT), you can relax knowing that you'll land at your destination as quickly as possible. If your American Airlines trip is delayed, you can expect a wait time of approximately 1 hour and 8 minutes. Because of the air carrier's first-rate service, this route has a 2.5-star rating.
What kind of plane is on flight number AA5378?
Chances are you'll be jumping on board a Bombardier CRJ900 if you've reserved a seat on flight AA5378. This flight nearly always sets off from MHT and touches down at CLT.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5378 flight with Travelocity, please visit our Customer Service Portal.