American Airlines Flight 5181 Deals & Information (2025/2026)

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American Airlines Flight 5181 Route Deals From $123

The cheapest prices found with in the last 7 days for return flights were $195 and $123 for one-way flights to Greenville-Spartanburg Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Oct 11 - Sat, Oct 25
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$195 Roundtrip, found 4 days ago
$195
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Oct 11 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Oct 25, priced at $195 found 4 days ago
Sat, Aug 9 - Thu, Aug 14
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$200 Roundtrip, found 4 days ago
$200
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Aug 9 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Thu, Aug 14, priced at $200 found 4 days ago
Fri, Aug 1 - Tue, Aug 5
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$202 Roundtrip, found 6 days ago
$202
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Aug 1 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Tue, Aug 5, priced at $202 found 6 days ago
Thu, Aug 21 - Sun, Aug 24
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$203 Roundtrip, found 1 day ago
$203
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 21 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sun, Aug 24, priced at $203 found 1 day ago
Sat, Jul 12 - Sat, Jul 19
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$206 Roundtrip, found 3 hours ago
$206
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Sat, Jul 12 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Jul 19, priced at $206 found 3 hours ago
Sat, Aug 9 - Thu, Aug 14
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$227 Roundtrip, found 4 days ago
$227
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Aug 9 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Thu, Aug 14, priced at $227 found 4 days ago
Sat, Aug 9 - Thu, Aug 14
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$228 Roundtrip, found 4 days ago
$228
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Aug 9 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Thu, Aug 14, priced at $228 found 4 days ago
Sat, Oct 11 - Sat, Oct 25
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$229 Roundtrip, found 4 days ago
$229
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Oct 11 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Oct 25, priced at $229 found 4 days ago
Thu, Aug 21 - Sun, Aug 24
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$230 Roundtrip, found 1 day ago
$230
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 21 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sun, Aug 24, priced at $230 found 1 day ago
Sat, Aug 9 - Sun, Aug 24
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$234 Roundtrip, found 16 hours ago
$234
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Sat, Aug 9 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sun, Aug 24, priced at $234 found 16 hours ago
Sat, Jul 19 - Fri, Jul 25
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$236 Roundtrip, found 3 hours ago
$236
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Sat, Jul 19 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Fri, Jul 25, priced at $236 found 3 hours ago
Fri, Aug 8 - Wed, Aug 13
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$237 Roundtrip, found 4 days ago
$237
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 8 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Wed, Aug 13, priced at $237 found 4 days ago
Thu, Oct 23 - Sat, Oct 25
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$238 Roundtrip, found 5 days ago
$238
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Oct 23 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Oct 25, priced at $238 found 5 days ago

Frequently asked questions

What route does flight number AA5181 take?
AA5181 is used on multiple routes, but the most common is between Philadelphia Airport and Hopkins Intl. Airport (CLE). If you're lucky enough to score a direct flight, you'll stroll through arrivals in 1 hour and 37 minutes. Multi-stop flights can also operate under this number, as can services on other routes.
How often is AA5181 on time?
If you're taking to the skies with American Airlines on flight number AA5181 from Philadelphia Intl. Airport (PHL) to Cleveland Hopkins Intl. Airport, your trip will be on time 91% of the time --- when you're running on a tight schedule, it's comforting to know your airline does too. In the rare event of an unexpected delay, the average wait is only 1 hour and 4 minutes. This trip has a 2.4-star rating.
What terminal does AA5181 fly out of?
Terminal F is the terminal you'll likely take off from if you're booked on a flight out of Philadelphia, PA Airport (PHL-Philadelphia Intl.). Philadelphia Intl. Airport (PHL) to Hopkins Intl. Airport (CLE) is the most commonly traveled route for flight number AA5181.
What kind of plane is on flight number AA5181?
It's more than likely you'll be climbing aboard the Bombardier CRJ900 if you've reserved a seat on flight AA5181 from Philadelphia Intl. Airport (PHL) to Cleveland Hopkins Intl. Airport. This is the most commonly used type of aircraft on this busy route.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5181 flight with Travelocity, please visit our Customer Service Portal.