American Airlines Flight 4421 Deals & Information (2026/2027)

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American Airlines Flight 4421 Route Deals From $46

The cheapest prices found with in the last 7 days for return flights were $152 and $46 for one-way flights to Memphis Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Apr 18 - Sat, Apr 25
ORD
O'Hare Intl.
MEM
Memphis Intl.
$152 Roundtrip, found 21 hours ago
$152
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Sat, Apr 18 from O'Hare Intl. to Memphis Intl., returning Sat, Apr 25, priced at $152 found 21 hours ago
Mon, Apr 13 - Thu, Apr 16
ORD
O'Hare Intl.
MEM
Memphis Intl.
$174 Roundtrip, found 1 day ago
$174
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Apr 13 from O'Hare Intl. to Memphis Intl., returning Thu, Apr 16, priced at $174 found 1 day ago
Sat, Feb 28 - Mon, Mar 2
ORD
O'Hare Intl.
MEM
Memphis Intl.
$175 Roundtrip, found 2 days ago
$175
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Feb 28 from O'Hare Intl. to Memphis Intl., returning Mon, Mar 2, priced at $175 found 2 days ago
Thu, Mar 5 - Mon, Mar 9
ORD
O'Hare Intl.
MEM
Memphis Intl.
$177 Roundtrip, found 3 days ago
$177
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Mar 5 from O'Hare Intl. to Memphis Intl., returning Mon, Mar 9, priced at $177 found 3 days ago
Mon, Mar 9 - Thu, Mar 12
ORD
O'Hare Intl.
MEM
Memphis Intl.
$177 Roundtrip, found 5 days ago
$177
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Mar 9 from O'Hare Intl. to Memphis Intl., returning Thu, Mar 12, priced at $177 found 5 days ago
Tue, Apr 21 - Wed, Apr 22
ORD
O'Hare Intl.
MEM
Memphis Intl.
$192 Roundtrip, found 21 hours ago
$192
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Apr 21 from O'Hare Intl. to Memphis Intl., returning Wed, Apr 22, priced at $192 found 21 hours ago
Tue, Feb 24 - Wed, Feb 25
ORD
O'Hare Intl.
MEM
Memphis Intl.
$197 Roundtrip, found 21 hours ago
$197
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Feb 24 from O'Hare Intl. to Memphis Intl., returning Wed, Feb 25, priced at $197 found 21 hours ago
Tue, Apr 14 - Wed, Apr 15
ORD
O'Hare Intl.
MEM
Memphis Intl.
$199 Roundtrip, found 21 hours ago
$199
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Apr 14 from O'Hare Intl. to Memphis Intl., returning Wed, Apr 15, priced at $199 found 21 hours ago
Tue, Apr 21 - Wed, Apr 22
ORD
O'Hare Intl.
MEM
Memphis Intl.
$201 Roundtrip, found 21 hours ago
$201
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Apr 21 from O'Hare Intl. to Memphis Intl., returning Wed, Apr 22, priced at $201 found 21 hours ago
Tue, Apr 14 - Wed, Apr 15
ORD
O'Hare Intl.
MEM
Memphis Intl.
$202 Roundtrip, found 21 hours ago
$202
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Apr 14 from O'Hare Intl. to Memphis Intl., returning Wed, Apr 15, priced at $202 found 21 hours ago