American Airlines Flight 4385 Deals & Information (2026/2027)

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American Airlines Flight 4385 Route Deals From $79

The cheapest prices found with in the last 7 days for return flights were $157 and $79 for one-way flights to Buffalo Niagara Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Jun 1 - Wed, Jun 3
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$157 Roundtrip, found 6 days ago
$157
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Jun 1 from LaGuardia to Buffalo Niagara Intl., returning Wed, Jun 3, priced at $157 found 6 days ago
Sun, Jun 28 - Wed, Jul 1
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$161 Roundtrip, found 1 day ago
$161
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Jun 28 from LaGuardia to Buffalo Niagara Intl., returning Wed, Jul 1, priced at $161 found 1 day ago
Fri, Jun 5 - Sun, Jun 14
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$181 Roundtrip, found 3 days ago
$181
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Jun 5 from LaGuardia to Buffalo Niagara Intl., returning Sun, Jun 14, priced at $181 found 3 days ago
Tue, May 19 - Thu, May 21
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$192 Roundtrip, found 6 days ago
$192
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, May 19 from LaGuardia to Buffalo Niagara Intl., returning Thu, May 21, priced at $192 found 6 days ago
Tue, May 26 - Fri, May 29
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$197 Roundtrip, found 2 days ago
$197
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, May 26 from LaGuardia to Buffalo Niagara Intl., returning Fri, May 29, priced at $197 found 2 days ago
Thu, Jul 9 - Fri, Jul 10
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$197 Roundtrip, found 2 days ago
$197
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jul 9 from LaGuardia to Buffalo Niagara Intl., returning Fri, Jul 10, priced at $197 found 2 days ago
Sat, Aug 29 - Mon, Aug 31
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$207 Roundtrip, found 1 day ago
$207
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 29 from LaGuardia to Buffalo Niagara Intl., returning Mon, Aug 31, priced at $207 found 1 day ago
Fri, Jun 19 - Tue, Jun 23
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$212 Roundtrip, found 13 hours ago
$212
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Fri, Jun 19 from LaGuardia to Buffalo Niagara Intl., returning Tue, Jun 23, priced at $212 found 13 hours ago
Fri, Jun 19 - Tue, Jun 23
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$212 Roundtrip, found 13 hours ago
$212
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Fri, Jun 19 from LaGuardia to Buffalo Niagara Intl., returning Tue, Jun 23, priced at $212 found 13 hours ago
Fri, Jun 19 - Tue, Jun 23
LGA
LaGuardia
BUF
Buffalo Niagara Intl.
$217 Roundtrip, found 13 hours ago
$217
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Fri, Jun 19 from LaGuardia to Buffalo Niagara Intl., returning Tue, Jun 23, priced at $217 found 13 hours ago

Frequently asked questions

What route does flight number AA4385 take?
AA4385 is used on a range of routes. More commonly, AA4385 flies straight from Charlotte-Douglas Intl. Airport (CLT) to DSM. If you have a ticket on this route, you'll be flying for approximately 2 hours and 38 minutes.
What kind of plane is on flight number AA4385?
There's a strong chance you'll be setting off on the Embraer 175 if you're jetting from Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.) to Des Moines, IA Airport (DSM-Des Moines Intl.), the most popular route for flight AA4385.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4385 flight with Travelocity, please visit our Customer Service Portal.