American Airlines Flight 381 Deals & Information (2025/2026)

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American Airlines Flight 381 Route Deals From $181

The cheapest prices found with in the last 7 days for return flights were $401 and $181 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Oct 22 - Sat, Oct 25
SEA
Seattle - Tacoma Intl.
CLT
Charlotte-Douglas Intl.
$401 Roundtrip, found 4 hours ago
$401
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Oct 22 from Seattle - Tacoma Intl. to Charlotte-Douglas Intl., returning Sat, Oct 25, priced at $401 found 4 hours ago
Wed, Oct 22 - Sat, Oct 25
SEA
Seattle - Tacoma Intl.
CLT
Charlotte-Douglas Intl.
$450 Roundtrip, found 4 hours ago
$450
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Oct 22 from Seattle - Tacoma Intl. to Charlotte-Douglas Intl., returning Sat, Oct 25, priced at $450 found 4 hours ago

Frequently asked questions

What route does flight number AA381 take?
AA381 is used on a number of routes. Mostly, AA381 flies direct from LaGuardia Airport to ORD. If you have a ticket on this route, you'll be in the air for about 2 hours and 55 minutes.
How often is AA381 on time?
Not fussed on hanging around at the airport? If you're traveling with American Airlines flight number AA381 from LaGuardia Airport (LGA) to ORD, this service runs as scheduled 92% of the time. On the odd occasion it is delayed, the average wait time is only 47 minutes. Just one of a multiple reasons that this journey has a 2.95-star rating.
What terminal does AA381 fly out of?
You'll most likely take off from Terminal B if you're booked on a flight out of LaGuardia Airport. AA381 serves a number of routes, but the direct flight between New York, NY Airport (LGA-LaGuardia) and O'Hare Intl. Airport (ORD) is the most frequently traveled one.
What kind of plane is on flight number AA381?
You're likely to be cruising aboard an Airbus A319 if you've reserved a ticket on flight number AA381 from New York, NY Airport (LGA-LaGuardia) to O'Hare Airport. It's the most commonly used aircraft type on this particular route.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA381 flight with Travelocity, please visit our Customer Service Portal.