American Airlines Flight AA381 Deals & Information (2025/2026)

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American Airlines Flight 381 Route Deals From $135

The cheapest prices found with in the last 7 days for return flights were $239 and $135 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Sep 4 - Tue, Sep 9
SEA
Seattle - Tacoma Intl.
CLT
Charlotte-Douglas Intl.
$239 Roundtrip, found 4 days ago
$239
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Sep 4 from Seattle - Tacoma Intl. to Charlotte-Douglas Intl., returning Tue, Sep 9, priced at $239 found 4 days ago
Thu, Aug 21 - Sat, Aug 30
SEA
Seattle - Tacoma Intl.
CLT
Charlotte-Douglas Intl.
$243 Roundtrip, found 4 days ago
$243
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Aug 21 from Seattle - Tacoma Intl. to Charlotte-Douglas Intl., returning Sat, Aug 30, priced at $243 found 4 days ago
Mon, Aug 18 - Fri, Aug 22
SEA
Seattle - Tacoma Intl.
CLT
Charlotte-Douglas Intl.
$261 Roundtrip, found 6 days ago
$261
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Aug 18 from Seattle - Tacoma Intl. to Charlotte-Douglas Intl., returning Fri, Aug 22, priced at $261 found 6 days ago
Thu, Sep 4 - Tue, Sep 9
SEA
Seattle - Tacoma Intl.
CLT
Charlotte-Douglas Intl.
$263 Roundtrip, found 4 days ago
$263
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Sep 4 from Seattle - Tacoma Intl. to Charlotte-Douglas Intl., returning Tue, Sep 9, priced at $263 found 4 days ago
Thu, Sep 4 - Tue, Sep 9
SEA
Seattle - Tacoma Intl.
CLT
Charlotte-Douglas Intl.
$277 Roundtrip, found 4 days ago
$277
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Sep 4 from Seattle - Tacoma Intl. to Charlotte-Douglas Intl., returning Tue, Sep 9, priced at $277 found 4 days ago
Sat, Jul 26 - Wed, Jul 30
SEA
Seattle - Tacoma Intl.
CLT
Charlotte-Douglas Intl.
$441 Roundtrip, found 1 day ago
$441
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jul 26 from Seattle - Tacoma Intl. to Charlotte-Douglas Intl., returning Wed, Jul 30, priced at $441 found 1 day ago

Frequently asked questions

What route does flight number AA381 take?
AA381 is used on a number of routes. Mostly, AA381 flies direct from LaGuardia Airport to ORD. If you have a ticket on this route, you’ll be in the air for about 2 hours and 55 minutes.
How often is AA381 on time?
Not fussed on hanging around at the airport? If you’re traveling with American Airlines flight number AA381 from LaGuardia Airport (LGA) to ORD, this service runs as scheduled 92% of the time. On the odd occasion it is delayed, the average wait time is only 47 minutes. Just one of a multiple reasons that this journey has a 2.95-star rating.
What terminal does AA381 fly out of?
You’ll most likely take off from Terminal B if you’re booked on a flight out of LaGuardia Airport. AA381 serves a number of routes, but the direct flight between New York, NY Airport (LGA-LaGuardia) and O’Hare Intl. Airport (ORD) is the most frequently traveled one.
What kind of plane is on flight number AA381?
You’re likely to be cruising aboard an Airbus A319 if you’ve reserved a ticket on flight number AA381 from New York, NY Airport (LGA-LaGuardia) to O’Hare Airport. It’s the most commonly used aircraft type on this particular route.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA381 flight with Travelocity, please visit our Customer Service Portal.