United Flight 4521 Deals & Information (2026/2027)

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United Flight 4521 Route Deals From $142

The cheapest prices found with in the last 7 days for return flights were $189 and $142 for one-way flights to McGhee Tyson for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Apr 1 - Sun, Apr 5
ORD
O'Hare Intl.
TYS
McGhee Tyson
$189 Roundtrip, found 15 hours ago
$189
Roundtrip
found 15 hours ago
Select United flight, departing Wed, Apr 1 from O'Hare Intl. to McGhee Tyson, returning Sun, Apr 5, priced at $189 found 15 hours ago
Fri, Feb 6 - Sun, Feb 8
ORD
O'Hare Intl.
TYS
McGhee Tyson
$194 Roundtrip, found 13 hours ago
$194
Roundtrip
found 13 hours ago
Select United flight, departing Fri, Feb 6 from O'Hare Intl. to McGhee Tyson, returning Sun, Feb 8, priced at $194 found 13 hours ago
Sat, Feb 7 - Sun, Feb 8
ORD
O'Hare Intl.
TYS
McGhee Tyson
$194 Roundtrip, found 5 days ago
$194
Roundtrip
found 5 days ago
Select United flight, departing Sat, Feb 7 from O'Hare Intl. to McGhee Tyson, returning Sun, Feb 8, priced at $194 found 5 days ago
Fri, Apr 17 - Thu, Apr 23
ORD
O'Hare Intl.
TYS
McGhee Tyson
$200 Roundtrip, found 2 days ago
$200
Roundtrip
found 2 days ago
Select United flight, departing Fri, Apr 17 from O'Hare Intl. to McGhee Tyson, returning Thu, Apr 23, priced at $200 found 2 days ago
Wed, Apr 1 - Sun, Apr 5
ORD
O'Hare Intl.
TYS
McGhee Tyson
$204 Roundtrip, found 15 hours ago
$204
Roundtrip
found 15 hours ago
Select United flight, departing Wed, Apr 1 from O'Hare Intl. to McGhee Tyson, returning Sun, Apr 5, priced at $204 found 15 hours ago
Sat, Jan 17 - Wed, Jan 21
ORD
O'Hare Intl.
TYS
McGhee Tyson
$222 Roundtrip, found 2 days ago
$222
Roundtrip
found 2 days ago
Select United flight, departing Sat, Jan 17 from O'Hare Intl. to McGhee Tyson, returning Wed, Jan 21, priced at $222 found 2 days ago
Thu, Jan 22 - Sun, Jan 25
ORD
O'Hare Intl.
TYS
McGhee Tyson
$231 Roundtrip, found 22 hours ago
$231
Roundtrip
found 22 hours ago
Select United flight, departing Thu, Jan 22 from O'Hare Intl. to McGhee Tyson, returning Sun, Jan 25, priced at $231 found 22 hours ago
Thu, Mar 26 - Sun, Mar 29
ORD
O'Hare Intl.
TYS
McGhee Tyson
$240 Roundtrip, found 6 days ago
$240
Roundtrip
found 6 days ago
Select United flight, departing Thu, Mar 26 from O'Hare Intl. to McGhee Tyson, returning Sun, Mar 29, priced at $240 found 6 days ago
Wed, Apr 1 - Sun, Apr 5
ORD
O'Hare Intl.
TYS
McGhee Tyson
$249 Roundtrip, found 15 hours ago
$249
Roundtrip
found 15 hours ago
Select United flight, departing Wed, Apr 1 from O'Hare Intl. to McGhee Tyson, returning Sun, Apr 5, priced at $249 found 15 hours ago
Thu, Jan 22 - Sun, Jan 25
ORD
O'Hare Intl.
TYS
McGhee Tyson
$255 Roundtrip, found 22 hours ago
$255
Roundtrip
found 22 hours ago
Select United flight, departing Thu, Jan 22 from O'Hare Intl. to McGhee Tyson, returning Sun, Jan 25, priced at $255 found 22 hours ago
Fri, Feb 6 - Sun, Feb 8
ORD
O'Hare Intl.
TYS
McGhee Tyson
$256 Roundtrip, found 13 hours ago
$256
Roundtrip
found 13 hours ago
Select United flight, departing Fri, Feb 6 from O'Hare Intl. to McGhee Tyson, returning Sun, Feb 8, priced at $256 found 13 hours ago
Wed, Jan 14 - Sat, Jan 17
ORD
O'Hare Intl.
TYS
McGhee Tyson
$256 Roundtrip, found 1 day ago
$256
Roundtrip
found 1 day ago
Select United flight, departing Wed, Jan 14 from O'Hare Intl. to McGhee Tyson, returning Sat, Jan 17, priced at $256 found 1 day ago

Frequently asked questions

What route does flight number UA4521 take?
You'll arrive into ORD from CLE if you're traveling on flight number UA4521. You'll be in the air for 1 hour and 28 minutes during this journey. It's also worthwhile noting that the service conveniently operates non-stop.
What kind of plane is on flight number UA4521?
You'll likely be boarding a Canadair (Bombardier) Regional Jet 550 if you're on flight number UA4521. Generally, this flight takes off from Hopkins Intl. Airport (CLE) and touches down at Chicago, IL Airport (ORD-O'Hare Intl.).
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your UA4521 flight with Travelocity, please visit our Customer Service Portal.