American Airlines Flight 5421 Deals & Information (2025/2026)

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American Airlines Flight 5421 Route Deals From $211

The cheapest prices found with in the last 7 days for return flights were $307 and $211 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Oct 4 - Tue, Oct 7
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$307 Roundtrip, found 6 days ago
$307
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Oct 4 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Oct 7, priced at $307 found 6 days ago
Sat, Oct 4 - Tue, Oct 7
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$317 Roundtrip, found 6 days ago
$317
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Oct 4 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Oct 7, priced at $317 found 6 days ago
Fri, Apr 24 - Tue, Apr 28
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$352 Roundtrip, found 3 days ago
$352
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Apr 24 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Apr 28, priced at $352 found 3 days ago
Fri, Apr 24 - Tue, Apr 28
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$362 Roundtrip, found 3 days ago
$362
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Apr 24 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Apr 28, priced at $362 found 3 days ago
Sat, Nov 8 - Tue, Nov 25
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$371 Roundtrip, found 1 day ago
$371
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 8 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Nov 25, priced at $371 found 1 day ago
Tue, Sep 30 - Tue, Oct 21
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$373 Roundtrip, found 13 hours ago
$373
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Sep 30 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Oct 21, priced at $373 found 13 hours ago
Sat, Oct 4 - Tue, Oct 7
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$374 Roundtrip, found 6 days ago
$374
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Oct 4 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Oct 7, priced at $374 found 6 days ago
Tue, Dec 2 - Mon, Dec 8
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$383 Roundtrip, found 4 days ago
$383
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Dec 2 from Quad City Intl. to Charlotte-Douglas Intl., returning Mon, Dec 8, priced at $383 found 4 days ago
Sat, Oct 4 - Tue, Oct 7
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$386 Roundtrip, found 6 days ago
$386
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Oct 4 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Oct 7, priced at $386 found 6 days ago
Sat, Oct 4 - Tue, Oct 7
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$389 Roundtrip, found 6 days ago
$389
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Oct 4 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Oct 7, priced at $389 found 6 days ago

Frequently asked questions

What route does flight number AA5421 take?
AA5421 takes a few routes. The most frequently flown is between PHF and Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), which is a direct flight. This service usually takes 1 hour and 27 minutes. That said, you might find other flights with the same number that are multi-stop.
What kind of plane is on flight number AA5421?
There's a strong chance you'll be setting off on the Bombardier CRJ700 if you're jetting from Newport News - Williamsburg Intl. Airport (PHF) to Charlotte Airport, one of several routes used for flight number AA5421.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5421 flight with Travelocity, please visit our Customer Service Portal.