American Airlines Flight 5421 Deals & Information (2025/2026)

Wander Wisely with exceptional service, 24/7 supportOpens in a new window

Feel at ease with free flight cancellations within 24 hours of booking

Change your flight without a fee on select flights

American Airlines Flight 5421 Route Deals From $228

The cheapest prices found with in the last 7 days for return flights were $352 and $228 for one-way flights to Charlotte-Douglas Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Apr 24 - Tue, Apr 28
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$352 Roundtrip, found 4 days ago
$352
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Apr 24 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Apr 28, priced at $352 found 4 days ago
Fri, Oct 31 - Mon, Nov 3
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$359 Roundtrip, just found
$359
Roundtrip
just found
Select American Airlines flight, departing Fri, Oct 31 from Quad City Intl. to Charlotte-Douglas Intl., returning Mon, Nov 3, priced at $359 just found
Fri, Apr 24 - Tue, Apr 28
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$362 Roundtrip, found 4 days ago
$362
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Apr 24 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Apr 28, priced at $362 found 4 days ago
Fri, Oct 31 - Mon, Nov 3
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$369 Roundtrip, just found
$369
Roundtrip
just found
Select American Airlines flight, departing Fri, Oct 31 from Quad City Intl. to Charlotte-Douglas Intl., returning Mon, Nov 3, priced at $369 just found
Tue, Dec 9 - Sat, Dec 13
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$371 Roundtrip, just found
$371
Roundtrip
just found
Select American Airlines flight, departing Tue, Dec 9 from Quad City Intl. to Charlotte-Douglas Intl., returning Sat, Dec 13, priced at $371 just found
Tue, Sep 30 - Tue, Oct 21
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$373 Roundtrip, found 1 day ago
$373
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 30 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Oct 21, priced at $373 found 1 day ago
Tue, Dec 2 - Mon, Dec 8
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$383 Roundtrip, found 4 days ago
$383
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Dec 2 from Quad City Intl. to Charlotte-Douglas Intl., returning Mon, Dec 8, priced at $383 found 4 days ago
Wed, Nov 26 - Mon, Dec 1
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$392 Roundtrip, just found
$392
Roundtrip
just found
Select American Airlines flight, departing Wed, Nov 26 from Quad City Intl. to Charlotte-Douglas Intl., returning Mon, Dec 1, priced at $392 just found
Fri, Apr 24 - Tue, Apr 28
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$393 Roundtrip, found 4 days ago
$393
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Apr 24 from Quad City Intl. to Charlotte-Douglas Intl., returning Tue, Apr 28, priced at $393 found 4 days ago
Tue, Dec 2 - Mon, Dec 8
MLI
Quad City Intl.
CLT
Charlotte-Douglas Intl.
$396 Roundtrip, found 4 days ago
$396
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Dec 2 from Quad City Intl. to Charlotte-Douglas Intl., returning Mon, Dec 8, priced at $396 found 4 days ago

Frequently asked questions

What route does flight number AA5421 take?
AA5421 takes a few routes. The most frequently flown is between PHF and Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.), which is a direct flight. This service usually takes 1 hour and 27 minutes. That said, you might find other flights with the same number that are multi-stop.
What kind of plane is on flight number AA5421?
There's a strong chance you'll be setting off on the Bombardier CRJ700 if you're jetting from Newport News - Williamsburg Intl. Airport (PHF) to Charlotte Airport, one of several routes used for flight number AA5421.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA5421 flight with Travelocity, please visit our Customer Service Portal.