American Airlines Flight 4385 Deals & Information (2025/2026)

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American Airlines Flight 4385 Route Deals From $80

The cheapest prices found with in the last 7 days for return flights were $141 and $80 for one-way flights to Indianapolis Intl. for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Oct 1 - Tue, Oct 7
JFK
John F. Kennedy Intl.
IND
Indianapolis Intl.
$141 Roundtrip, found 23 hours ago
$141
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Oct 1 from John F. Kennedy Intl. to Indianapolis Intl., returning Tue, Oct 7, priced at $141 found 23 hours ago
Wed, Aug 27 - Sat, Aug 30
JFK
John F. Kennedy Intl.
IND
Indianapolis Intl.
$154 Roundtrip, found 5 hours ago
$154
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Aug 27 from John F. Kennedy Intl. to Indianapolis Intl., returning Sat, Aug 30, priced at $154 found 5 hours ago
Wed, Oct 1 - Tue, Oct 7
JFK
John F. Kennedy Intl.
IND
Indianapolis Intl.
$160 Roundtrip, found 23 hours ago
$160
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Oct 1 from John F. Kennedy Intl. to Indianapolis Intl., returning Tue, Oct 7, priced at $160 found 23 hours ago
Wed, Sep 3 - Sun, Sep 7
JFK
John F. Kennedy Intl.
IND
Indianapolis Intl.
$160 Roundtrip, found 13 hours ago
$160
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Wed, Sep 3 from John F. Kennedy Intl. to Indianapolis Intl., returning Sun, Sep 7, priced at $160 found 13 hours ago
Thu, Aug 28 - Sun, Aug 31
JFK
John F. Kennedy Intl.
IND
Indianapolis Intl.
$168 Roundtrip, found 5 hours ago
$168
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Thu, Aug 28 from John F. Kennedy Intl. to Indianapolis Intl., returning Sun, Aug 31, priced at $168 found 5 hours ago
Wed, Aug 27 - Sat, Aug 30
JFK
John F. Kennedy Intl.
IND
Indianapolis Intl.
$180 Roundtrip, found 5 hours ago
$180
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Aug 27 from John F. Kennedy Intl. to Indianapolis Intl., returning Sat, Aug 30, priced at $180 found 5 hours ago
Thu, Sep 25 - Sun, Sep 28
JFK
John F. Kennedy Intl.
IND
Indianapolis Intl.
$183 Roundtrip, found 6 hours ago
$183
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Thu, Sep 25 from John F. Kennedy Intl. to Indianapolis Intl., returning Sun, Sep 28, priced at $183 found 6 hours ago
Wed, Jul 16 - Wed, Jul 23
JFK
John F. Kennedy Intl.
IND
Indianapolis Intl.
$187 Roundtrip, found 1 day ago
$187
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 16 from John F. Kennedy Intl. to Indianapolis Intl., returning Wed, Jul 23, priced at $187 found 1 day ago
Mon, Aug 18 - Wed, Aug 20
JFK
John F. Kennedy Intl.
IND
Indianapolis Intl.
$187 Roundtrip, found 3 days ago
$187
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Aug 18 from John F. Kennedy Intl. to Indianapolis Intl., returning Wed, Aug 20, priced at $187 found 3 days ago
Thu, Aug 21 - Sun, Aug 24
JFK
John F. Kennedy Intl.
IND
Indianapolis Intl.
$190 Roundtrip, found 2 days ago
$190
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Aug 21 from John F. Kennedy Intl. to Indianapolis Intl., returning Sun, Aug 24, priced at $190 found 2 days ago

Frequently asked questions

What route does flight number AA4385 take?
AA4385 is used on a range of routes. More commonly, AA4385 flies straight from Charlotte-Douglas Intl. Airport (CLT) to DSM. If you have a ticket on this route, you'll be flying for approximately 2 hours and 38 minutes.
What kind of plane is on flight number AA4385?
There's a strong chance you'll be setting off on the Embraer 175 if you're jetting from Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.) to Des Moines, IA Airport (DSM-Des Moines Intl.), the most popular route for flight AA4385.
If I am not able to travel due to COVID-19, can I change my flight to a later date?
For more info about changing your AA4385 flight with Travelocity, please visit our Customer Service Portal.