Find a Hotel in Downtown Clayton
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Top hotels in Downtown Clayton

Drury Plaza Hotel St. Louis at the Arch
Everything was good. The staff was awesome, room very clean, food and drink was great.
Reviewed on Jan 19, 2026

The Ritz-Carlton, St. Louis
Very courteo
Reviewed on Jan 13, 2026

AC Hotel St. Louis Clayton
My room was spotless and very well put together.
Reviewed on Jan 9, 2026

21C Museum Hotel St Louis
Always a wonderful stay! The staff is top notch and the space is perfect for the imaginative mind! Love love love!
Reviewed on Jan 25, 2026

Clayton Plaza Hotel & Extended Stay
Everything was good. Room large, shower good, staff was courteous and professional. They could use some extra touches, like pictures on the wall, a rug on the flooring to warm it up, etc.
Reviewed on Jan 20, 2026

Le Méridien St. Louis Clayton
Nice
Reviewed on Jan 5, 2026

Pear Tree Inn St. Louis Near Union Station
Great staff!
Reviewed on Jan 19, 2026

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Super helpful staff! The hotel lobby has so much character!
Reviewed on Jan 20, 2026

Hyatt Regency St. Louis at The Arch
Great location and vibe. I will definitely return
Reviewed on Jan 23, 2026
Downtown Clayton Hotel Guide
Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.
Nowhere else can you find better deals on Downtown Clayton area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Downtown Clayton to find the perfect one to will fit your budget.
Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Downtown Clayton are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.
Recent Downtown Clayton hotel reviews by fellow wanderers

21C Museum Hotel St Louis
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