Explore top 2026 5 Star Hotels in Syracuse

Name: Dimora Caiammari Luxury Hotel & Spa
Price range: $374 total
Rating: 9.4

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Top Syracuse 5 Star hotels

Ortea Palace Hotel, Sicily, Autograph Collection

Via Riva Nazario Sauro Syracuse SR

Fully refundableReserve now, pay when you stay

$506 nightly

$568 total

Sep 27 - Sep 28

Total with taxes and fees

A full-service spa, 2 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

Grand Hotel Ortigia Siracusa

Viale Mazzini, 12 Syracuse SR

Fully refundableReserve now, pay when you stay

$338 nightly

$383 total

Sep 27 - Sep 28

Total with taxes and fees

This hotel features a restaurant, a rooftop terrace, and a bar/lounge. Take the beach shuttle and relax with sun loungers and beach umbrellas. WiFi in public ...

9/10 Wonderful! (621 reviews)

"Old world Italian charm and great service. Would have preferred something more centrally located with a pool and better breakfast."

Reviewed on Aug 29, 2026

Grand Hotel Des Ètrangers - The Leading Hotels of the World

Passeggio Adorno 10/12 Syracuse SR

Fully refundableReserve now, pay when you stay

$646 nightly

$722 total

Sep 7 - Sep 8

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public areas, ...

Caportigia Boutique Hotel

Viale Montedoro 76 Syracuse SR

Fully refundableReserve now, pay when you stay

$211 nightly

$244 total

Sep 3 - Sep 4

Total with taxes and fees

This hotel features a restaurant, a hot tub, and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. You'll appreciate ...

Minareto

Via del Faro Massolivieri 26 Syracuse SR

$396 nightly

$448 total

Sep 11 - Sep 12

Total with taxes and fees

This luxury hotel features a private beach, a full-service spa, and 2 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Families ...

Wellness & Spa Hotel Principe di Fitalia

Traversa Tonnara di Terrauzza 51 Syracuse SR

Fully refundableReserve now, pay when you stay

$472 nightly

$531 total

Sep 28 - Sep 29

Total with taxes and fees

An attached winery, a full-service spa, and 2 outdoor pools are all featured at this luxury hotel. There's fun for all ages with a children's club and a children's ...

9.6/10 Exceptional! (97 reviews)

"A very well maintained hotel. An excellent pool. Incredibly helpful staff even though we speak very limited Italian and an exceptional breakfast."

Reviewed on Jul 12, 2026

Dimora Caiammari Luxury Hotel & Spa

Via Daniele Impellizzeri Syracuse SR

$330 nightly

$374 total

Sep 4 - Sep 5

Total with taxes and fees

This luxury hotel features a full-service spa, 2 outdoor pools, and a restaurant. There's fun for all ages with a children's pool and a playground, and families ...

9.4/10 Exceptional! (216 reviews)

"Fabulous boutique resort. Friendly and welcoming staff with great local tips re beaches, restaurants and towns to visit. Excellent food. Highly recommended!"

Reviewed on Aug 16, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Syracuse Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Syracuse to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Syracuse 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Syracuse before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Syracuse hotel reviews by fellow wanderers

Lanterne Magiche Ortigia

5 out of 5

Posted 1 day ago

Travelocity Verified Review

"The property was very clean and quite large. Our room was super spacious and clean. The staff was friendly and helpful, especially Alessandra at the front desk. Also the location was very walkable to everything."

A verified traveler stayed at Lanterne Magiche Ortigia