Explore top 2025 4 Star Hotels in Clemson

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Top Clemson 4 Star hotels

The Shepherd Hotel Downtown Clemson

110 Sloan St, Clemson, SC

$189 nightly

$210 total

Oct 28 - Oct 29

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...

9.6/10 Exceptional! (711 reviews)

"Beautiful hotel with an amazing, helpful and attentive staff. Highly recommend"

Reviewed on Oct 21, 2025

The Abernathy of Clemson

157 Old Greenville Hwy, Clemson, SC

$154 nightly

$171 total

Nov 18 - Nov 19

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...

9.6/10 Exceptional! (548 reviews)

"Amazing rooms with great amenities. Perfect location for Clemson"

Reviewed on Oct 15, 2025

Liberty Hall Bed and Breakfast

621 S Mechanic St, Pendleton, SC

$210 nightly

$233 total

Nov 11 - Nov 12

Total with taxes and fees

This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the free full breakfast each morning. A garden, express ...

9.8/10 Exceptional! (74 reviews)

"Excellent property with spacious rooms and a great front porch with rocking chairs to relax in. Fabulous breakfast every day. But most important was the staff. Angela and Micheal were very welcoming and ready to help with anything you might need. Would definitely return."

Reviewed on Sep 2, 2025

Southern Sunshine Retreat

901 Huntington Rd, Easley, Sc 29642, Usa, Easley, SC

This vacation home includes free WiFi in public areas and barbecue grills.

Get rates

Lake Hartwell Frank Howard Home Clemson

7008 SC-187, Anderson, SC

$321 nightly

$356 total

Nov 19 - Nov 20

Total with taxes and fees

Stay at this 4-star vacation home in Anderson. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Woodburn and Agricultural Museum are ...

Belvedere

302 Alameda Ln, Anderson, SC

This vacation home features barbecue grills. Take advantage of the free self parking.

8/10 Very Good! (1 review)

Ok but…

"Bring everything. Including hangers for your clothes, salt and pepper, etc. it is like staying at a place that has one purpose, to rent out. Beds are uncomfortable. Nice big closets with one wire hanger. Why???"

Reviewed on Feb 9, 2025

Get rates

228 Lakeland

228 Lakeland Dr, Anderson, SC

This vacation home features barbecue grills. Take advantage of the free self parking.

Get rates

Pendleton

119 Weaver Way, Pendleton, SC

This vacation home features barbecue grills. Take advantage of the free self parking.

Get rates

Don't see what you're looking for?

See all available properties in Clemson

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Clemson

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Clemson 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Clemson will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Clemson, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.