Explore 31 Luxury Hotels in South Region

Best Luxury Hotels in South Region

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32, Iguassu National Park, Foz do Iguaçu, PR

Fully refundableReserve now, pay when you stay

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. There's fun for all ages with a free kid's club and a children's ...

9.8/10 Exceptional! (1,002 reviews)

"Wonderful hotel location and very nice staff"

Reviewed on Jun 1, 2025

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Nomaa Hotel

Rua Gutemberg,168, Batel, Curitiba, PR

Fully refundableReserve now, pay when you stay

A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.6/10 Exceptional! (398 reviews)

"Nomaa is one of the best, most luxury hotels I have stayed in! Everything from the room amenities to the fine dining services exceeded expectations. I would highly recommend for business travelers or luxury vacationers!"

Reviewed on Aug 19, 2024

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Iguazu Grand Resort Spa & Casino

Route 12 Km 1640, Puerto Iguazú, Misiones

Fully refundableReserve now, pay when you stay

This smoke-free hotel features a casino, a full-service spa, and a nightclub. There's fun for all ages with a free kid's club and mini golf, and in-room childcare ...

9/10 Wonderful! (544 reviews)

"Great staff!"

Reviewed on May 27, 2025

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Gran Melia Iguazú

Parque Nacional Iguazu, Puerto Iguazú, Misiones

Fully refundableReserve now, pay when you stay

A full-service spa, 3 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...

9/10 Wonderful! (1,002 reviews)

"Hotel's location inside the national park is perfect. Matching up to a 5star hotel. Service is excellent. Breakfast is the best. we enjoyed our 3 nights stay very much"

Reviewed on Jun 4, 2025

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Novotel Florianópolis

Av. Rubens Arruda Ramos, 2034, Centro, Florianópolis, SC

Fully refundableReserve now, pay when you stay

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9/10 Wonderful! (1,005 reviews)

"Cafe da manhã mto bom Excelente localização Limpeza"

Reviewed on Jun 5, 2025

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Felissimo Exclusive Hotel

201 Alles Blaun, Balneário Camboriú, SC

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the hot tub and free perks like buffet breakfast and free self parking. You'll appreciate ...

9/10 Wonderful! (68 reviews)

"Fantastic"

Reviewed on Sep 12, 2024

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Spa do Vinho Hotel & Condomínio Vitivinícola

Rod. RS 444, KM 21, Vale dos Vinhedos, Bento Gonçalves, RS

Fully refundableReserve now, pay when you stay

A full-service spa, 4 restaurants, and an outdoor pool are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, free ...

9/10 Wonderful! (1,001 reviews)

"Spectacular place, staff go above & beyond, perfect getaway 💕"

Reviewed on Feb 6, 2023

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Infinity Blue Resort & Spa

Avenida Rui Barbosa 1000, Balneário Camboriú, SC

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this luxury hotel. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. ...

Boas instalações, nas serviço deixa a desejar.

"Hotel tem boas instalações; Mas não está com protocolos da Covid19 adequados. Empregados dos restaurantes e recreadores com máscaras inadequadas, fazendo com que alguns constantemente ficassem com elas caindo expondo nariz e boca, mesmo após alertados o problema continuou; Carta de vinho desatualizada ..."

Reviewed on Dec 20, 2020

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More 4 star hotels in South Region

LK Design Hotel

R. Bocaiúva 1755, Florianópolis, SC

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9.6/10 Exceptional! (684 reviews)

5 star hotels in South Region

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32, Iguassu National Park, Foz do Iguaçu, PR

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9.8/10 Exceptional! (1,002 reviews)

South Region Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South Region luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South Region to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South Region will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South Region, and plan your next opulent escape.

South Region hotels essential information

Accommodation	9,546 hotels
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Popular hotels	Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, Iguazu Grand Resort Spa & Casino, Gran Melia Iguazú, Novotel Florianópolis, Felissimo Exclusive Hotel, Spa do Vinho Hotel & Condomínio Vitivinícola, Infinity Blue Resort & Spa, Nomaa Hotel