Deals on vacations and trips to Puxico

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Price found within the past 48 hours. Click for updated prices.
University Inn of Carbondale

University Inn of Carbondale

2.5 out of 5
Price was $781, price is now $732 per person
$732
per person
Jan 25 - Jan 31
found 1 day ago
Roundtrip flight included
Sarasota (SRQ) to Cape Girardeau (CGI)
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business center. Staff at the 24-hour front desk can provide around-the-clock assistance.
Hampton Inn Carbondale

Hampton Inn Carbondale

2.5 out of 5
Price was $1,007, price is now $821 per person
$821
per person
Jan 25 - Jan 31
found 1 day ago
Roundtrip flight included
Sarasota (SRQ) to Cape Girardeau (CGI)
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like buffet breakfast and free self parking.
Holiday Inn Carbondale-Conference Center by IHG

Holiday Inn Carbondale-Conference Center by IHG

3 out of 5
Price was $981, price is now $896 per person
$896
per person
Jan 25 - Jan 31
found 1 day ago
Roundtrip flight included
Sarasota (SRQ) to Cape Girardeau (CGI)
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free self parking, a terrace, and express check-out are also offered.
Quality Inn Carbondale University area

Quality Inn Carbondale University area

2.5 out of 5
Price was $804, price is now $740 per person
$740
per person
Jan 25 - Jan 31
found 1 day ago
Roundtrip flight included
Sarasota (SRQ) to Cape Girardeau (CGI)
This hotel features free WiFi in public areas, laundry facilities, and free self parking. Free buffet breakfast is served. A snack bar/deli, a hair salon, and a picnic area are also on offer.
Home2 Suites by Hilton Carbondale

Home2 Suites by Hilton Carbondale

3 out of 5
Price was $985, price is now $942 per person
$942
per person
Jan 25 - Jan 31
found 1 day ago
Roundtrip flight included
Sarasota (SRQ) to Cape Girardeau (CGI)
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.

Top Puxico hotels deals

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
$76 nightly
The price is $80 total per night
$80 total
Dec 23 - Dec 24
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.
Pet friendly
Parking included
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 out of 5
3109 Oak Grove Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
$104 nightly
The price is $117 total per night
$117 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.
Pool
Breakfast included
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3 out of 5
2220 N Westwood Blvd Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
$106 nightly
The price is $120 total per night
$120 total
Dec 27 - Dec 28
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Hot Tub
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd Poplar Bluff MO
Free Cancellation
$110 nightly
The price is $124 total per night
$124 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and perks like free self parking.
Pool
Pet friendly
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 out of 5
2420 Crestwood Dr Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
$113 nightly
The price is $126 total per night
$126 total
Jan 10 - Jan 11, 2026
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. A business center, express check-in, and express check-out are also on offer.
Pool
Breakfast included
Dexter Inn

Dexter Inn

2.5 out of 5
1807 W Business US Highway 60 Dexter MO
Free Cancellation
Reserve now, pay when you stay
$68 nightly
The price is $76 total per night
$76 total
Dec 23 - Dec 24
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Staff at the 24-hour front desk can provide around-the-clock assistance.
Pool
Pet friendly
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much are vacation packages to Puxico?
You can pick up an amazing flight and hotel bundle for as low as $732. With one of our Travelocity vacation packages, a getaway to Puxico has never looked more irresistible! Save some time and money and then get a head start on packing those bags.
Where can I get the best vacation package deals for Puxico?
No matter how you like to travel, Travelocity can help you find the perfect Puxico package deal. All you need to do is mix and match from our 400 partner airlines and 1,000,000 worldwide properties.
Why should I book my Puxico vacation package with Travelocity?
Whether you're on the hunt for the ultimate unplugged vacation or you crave the hustle and bustle that only a big city can provide, booking everything with Travelocity saves you time, money and hassle. No need to sift through countless websites to find the best deal — our Price Match Guarantee ensures you'll never be out of pocket, and our professional customer service experts are available 24/7.
Can I save money on my Puxico car rental if I combine it with hotels and flights?
Sure can — combine your car, flight and hotel into a Puxico vacation package and you can save loads. With so many places to explore in Puxico, that rental car will make it easy to explore. Once you've buckled yourself in, turn up the stereo and make your way to Busch Stadium, a well-known sight approximately 120 mi from Puxico.
Which airport is best for Puxico?
Cape Girardeau Municipal Airport (CGI) is the top airport for visitors jetting to Puxico. Once you get there, you'll be 40 mi northeast of the center of town.

Photos of local treasures

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